The Stability of Treatment Preferences Among Patients With Advanced Cancer
Lea J Jabbarian, Renee C Maciejewski, Paul K Maciejewski, Judith A C Rietjens, Ida J Korfage, Agnes van der Heide, Johannes J M van Delden, Holly G Prigerson, Lea J Jabbarian, Renee C Maciejewski, Paul K Maciejewski, Judith A C Rietjens, Ida J Korfage, Agnes van der Heide, Johannes J M van Delden, Holly G Prigerson
Abstract
Context: Stability of patients' treatment preferences has important implications for decisions about concurrent and future treatment.
Objectives: To examine the stability of treatment preferences and correlates among patients with advanced cancer.
Methods: In this cohort, 104 patients with metastatic cancer, progression after at least one chemotherapy regimen, and an oncologist-estimated life expectancy of six or fewer months participated in structured interviews after clinical visits in which patients' recent scan results were discussed. Interviews were repeated in three monthly follow-ups. At baseline, patients' age, education, sex, race, marital status, insurance status, and type of cancer were documented. At each assessment, patients reported their treatment preferences (i.e., prioritizing life-prolonging vs. comfort), quality of life, and current health status.
Results: At baseline (n = 104), 55 (53%) patients preferred life-prolonging care and 49 (47%) preferred comfort care. Patients were followed up for one (n = 104), two (n = 74), or three months (n = 44). Between baseline and Month 1, 84 patients (81%) had stable preferences. During follow-up, preferences of 71 patients (68%) remained stable (equally divided between a consistent preference for life-prolonging and comfort care). Treatment preferences of 33 (32%) patients changed at least once during follow-up. Direction of change was inconsistent. Patients' preferences at baseline strongly predicted preferences at Month 1 (odds ratio = 17.8; confidence interval = 6.7-47.3; P < .001). Description of the current health status at baseline was the only variable significantly associated with stability of preferences at Month 1.
Conclusion: Two-thirds of patients with advanced cancer had stable preferences. Changes of preferences were often inconsistent and unpredictable. Our findings suggest potential benefits of ongoing communication about preferences.
Keywords: Cancer; advance care planning; decision-making; patient care planning; patient preference.
Conflict of interest statement
DISCLOSURES
The authors declare that there are no competing interests.
Copyright © 2019 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.
Figures
![Figure 1.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6700722/bin/nihms-1527314-f0001.jpg)
![Figure 2a.. Preferences over Time, Beginning with…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6700722/bin/nihms-1527314-f0002.jpg)
![Figure 2b.. Preferences over Time, Beginning with…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6700722/bin/nihms-1527314-f0003.jpg)
Source: PubMed