Platelet-Rich Plasma as a Potential New Strategy in the Endometrium Treatment in Assisted Reproductive Technology

Yunying Lin, Jia Qi, Yun Sun, Yunying Lin, Jia Qi, Yun Sun

Abstract

The success rate of assisted reproduction techniques (ART) has long been less than satisfactory albeit the great progress made in recent years, demonstrating the need for alternative options in the ART cycles. Growing evidence correlates the effect of intrauterine platelet-rich plasma (PRP) infusion on the endometrium with reassuring reproductive results. Thus, in this review, we focus on the current clinical and mechanical evidence on PRP and its effect on endometrial receptivity, and assess the features, benefits and limitations of the current studies and potential risks of PRP in ART.

Keywords: assisted reproduction techniques; endometrial receptivity; mechanisms; platelet-rich plasma; risk.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2021 Lin, Qi and Sun.

Figures

Figure 1
Figure 1
The potential mechanisms of PRP on endometrial receptivity in assisted reproductive technology. PRP might improve the endometrial receptivity through the improvement of cell proliferation, vascularization, anti-inflammatory properties and the reduction in the degree of fibrosis, with the help of the concentrated peptides, GFs and cytokines in PRP.

References

    1. Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, et al. . Conventional and Modern Markers of Endometrial Receptivity: A Systematic Review and Meta-Analysis. Hum Reprod Update (2019) 25(2):202–23. doi: 10.1093/humupd/dmy044
    1. Bos-Mikich A, de Oliveira R, Frantz N. Platelet-Rich Plasma Therapy and Reproductive Medicine. J Assist Reprod Genet (2018) 35(5):753–6. doi: 10.1007/s10815-018-1159-8
    1. Maleki-Hajiagha A, Razavi M, Rouholamin S, Rezaeinejad M, Maroufizadeh S, Sepidarkish M. Intrauterine Infusion of Autologous Platelet-Rich Plasma in Women Undergoing Assisted Reproduction: A Systematic Review and Meta-Analysis. J Reprod Immunol (2020) 137:103078. doi: 10.1016/j.jri.2019.103078
    1. Bos-Mikich A, Ferreira MO, de Oliveira R, Frantz N. Platelet-Rich Plasma or Blood-Derived Products to Improve Endometrial Receptivity? J Assist Reprod Genet (2019) 36(4):613–20. doi: 10.1007/s10815-018-1386-z
    1. Marques LF, Stessuk T, Camargo IC, Sabeh Junior N, dos Santos L, Ribeiro-Paes JT. Platelet-Rich Plasma (PRP): Methodological Aspects and Clinical Applications. Platelets (2015) 26(2):101–13. doi: 10.3109/09537104.2014.881991
    1. Kim JH, Park M, Paek JY, Lee WS, Song H, Lyu SW. Intrauterine Infusion of Human Platelet-Rich Plasma Improves Endometrial Regeneration and Pregnancy Outcomes in a Murine Model of Asherman's Syndrome. Front Physiol (2020) 11:105. doi: 10.3389/fphys.2020.00105
    1. Drago L, Bortolin M, Vassena C, Taschieri S, Del Fabbro M. Antimicrobial Activity of Pure Platelet-Rich Plasma Against Microorganisms Isolated From Oral Cavity. BMC Microbiol (2013) 13:47. doi: 10.1186/1471-2180-13-47
    1. Urman B, Boza A, Balaban B. Platelet-Rich Plasma Another Add-on Treatment Getting Out of Hand? How can Clinicians Preserve the Best Interest of Their Patients? Hum Reprod (2019) 34(11):2099–103. doi: 10.1093/humrep/dez190
    1. Pietrzak WS, Eppley BL. Platelet Rich Plasma: Biology and New Technology. J Craniofac Surg (2005) 16(6):1043–54. doi: 10.1097/
    1. Bendinelli P, Matteucci E, Dogliotti G, Corsi MM, Banfi G, Maroni P, et al. . Molecular Basis of Anti-Inflammatory Action of Platelet-Rich Plasma on Human Chondrocytes: Mechanisms of NF-κb Inhibition via HGF. J Cell Physiol (2010) 225(3):757–66. doi: 10.1002/jcp.22274
    1. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of Platelet Concentrates: From Pure Platelet-Rich Plasma (P-PRP) to Leucocyte- and Platelet-Rich Fibrin (L-PRF). Trends Biotechnol (2009) 27(3):158–67. doi: 10.1016/j.tibtech.2008.11.009
    1. Zhu Y, Yuan M, Meng HY, Wang AY, Guo QY, Wang Y, et al. . Basic Science and Clinical Application of Platelet-Rich Plasma for Cartilage Defects and Osteoarthritis: A Review. Osteoarthritis Cartilage (2013) 21(11):1627–37. doi: 10.1016/j.joca.2013.07.017
    1. Whitney KE, Liebowitz A, Bolia IK, Chahla J, Ravuri S, Evans TA, et al. . Current Perspectives on Biological Approaches for Osteoarthritis. Ann N Y Acad Sci (2017) 1410(1):26–43. doi: 10.1111/nyas.13554
    1. Wasterlain AS, Braun HJ, Harris AH, Kim HJ, Dragoo JL. The Systemic Effects of Platelet-Rich Plasma Injection. Am J Sports Med (2013) 41(1):186–93. doi: 10.1177/0363546512466383
    1. Zhang M, Park G, Zhou B, Luo D. Applications and Efficacy of Platelet-Rich Plasma in Dermatology: A Clinical Review. J Cosmet Dermatol (2018) 17(5):660–5. doi: 10.1111/jocd.12673
    1. Samadi P, Sheykhhasan M, Khoshinani HM. The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review. Aesthetic Plast Surg (2019) 43(3):803–14. doi: 10.1007/s00266-018-1293-9
    1. Callejo J, Salvador C, González-Nuñez S, Almeida L, Rodriguez L, Marqués L, et al. . Live Birth in a Woman Without Ovaries After Autograft of Frozen-Thawed Ovarian Tissue Combined With Growth Factors. J Ovarian Res (2013) 6(1):33. doi: 10.1186/1757-2215-6-33
    1. Sills ES, Wood SH. Autologous Activated Platelet-Rich Plasma Injection Into Adult Human Ovary Tissue: Molecular Mechanism, Analysis, and Discussion of Reproductive Response. Biosci Rep (2019) 39(6). doi: 10.1042/BSR20190805
    1. Hosseini L, Shirazi A, Naderi MM, Shams-Esfandabadi N, Borjian Boroujeni S, Sarvari A, et al. . Platelet-Rich Plasma Promotes the Development of Isolated Human Primordial and Primary Follicles to the Preantral Stage. Reprod BioMed Online (2017) 35(4):343–50. doi: 10.1016/j.rbmo.2017.04.007
    1. Sfakianoudis K, Simopoulou M, Nitsos N, Rapani A, Pantou A, Vaxevanoglou T, et al. . A Case Series on Platelet-Rich Plasma Revolutionary Management of Poor Responder Patients. Gynecol Obstet Invest (2019) 84(1):99–106. doi: 10.1159/000491697
    1. Wang X, Liu L, Mou S, Zhao H, Fang J, Xiang Y, et al. . Investigation of Platelet-Rich Plasma in Increasing Proliferation and Migration of Endometrial Mesenchymal Stem Cells and Improving Pregnancy Outcome of Patients With Thin Endometrium. J Cell Biochem (2018) 120(5):7403–11. doi: 10.1002/jcb.28014
    1. Chang Y, Li J, Wei LN, Pang J, Chen J, Liang X. Autologous Platelet-Rich Plasma Infusion Improves Clinical Pregnancy Rate in Frozen Embryo Transfer Cycles for Women With Thin Endometrium. Medicine (2019) 98(3):e14062. doi: 10.1097/MD.0000000000014062
    1. Chang Y, Li J, Chen Y, Wei L, Yang X. Autologous Platelet-Rich Plasma Promotes Endometrial Growth and Improves Pregnancy Outcome During In Vitro Fertilization. Int J Clin Exp Med (2015) 8(1):1286–90.
    1. Zadehmodarres S, Salehpour S, Saharkhiz N, Nazari L. Treatment of Thin Endometrium With Autologous Platelet-Rich Plasma: A Pilot Study. JBRA Assist Reprod (2017) 21(1):54–6. doi: 10.5935/1518-0557.20170013
    1. Eftekhar M, Neghab N, Naghshineh E, Khani P. Can Autologous Platelet Rich Plasma Expand Endometrial Thickness and Improve Pregnancy Rate During Frozen-Thawed Embryo Transfer Cycle? A Randomized Clinical Trial. Taiwan J Obstet Gynecol (2018) 57(6):810–3. doi: 10.1016/j.tjog.2018.10.007
    1. Nazari L, Salehpour S, Hoseini S, Zadehmodarres S, Azargashb E. Effects of Autologous Platelet-Rich Plasma on Endometrial Expansion in Patients Undergoing Frozen-Thawed Embryo Transfer: A Double-Blind RCT. Int J Reprod BioMed (2019) 17(6):443–8. doi: 10.18502/ijrm.v17i6.4816
    1. Kim H, Shin JE, Koo HS, Kwon H, Choi DH, Kim JH. Effect of Autologous Platelet-Rich Plasma Treatment on Refractory Thin Endometrium During the Frozen Embryo Transfer Cycle: A Pilot Study. Front Endocrinol (Lausanne) (2019) 10:61. doi: 10.3389/fendo.2019.00061
    1. Agarwal M, Mettler L, Jain S, Meshram S, Gunther V, Alkatout I. Management of a Thin Endometrium by Hysteroscopic Instillation of Platelet-Rich Plasma Into The Endomyometrial Junction: A Pilot Study. J Clin Med (2020) 9(9):2795. doi: 10.3390/jcm9092795
    1. Frantz N, Ferreira M, Kulmann MI, Frantz G, Bos-Mikich A, Oliveira R. Platelet-Rich Plasma as an Effective Alternative Approach for Improving Endometrial Receptivity - A Clinical Retrospective Study. JBRA Assist Reprod (2020) 24(4):442–6. doi: 10.5935/1518-0557.20200026
    1. Nazari L, Salehpour S, Hoseini S, Zadehmodarres S, Ajori L. Effects of Autologous Platelet-Rich Plasma on Implantation and Pregnancy in Repeated Implantation Failure: A Pilot Study. Int J Reprod Biomed (2016) 14(10):625–8. doi: 10.29252/ijrm.14.10.625
    1. Coksuer H, Akdemir Y, Ulas Barut M. Improved In Vitro Fertilization Success and Pregnancy Outcome With Autologous Platelet-Rich Plasma Treatment in Unexplained Infertility Patients That had Repeated Implantation Failure History. Gynecol Endocrinol (2019) 35(9):815–8. doi: 10.1080/09513590.2019.1597344
    1. Mehrafza M, Kabodmehri R, Nikpouri Z, Pourseify G, Raoufi A, Eftekhari A, et al. . Comparing the Impact of Autologous Platelet-Rich Plasma and Granulocyte Colony Stimulating Factor on Pregnancy Outcome in Patients With Repeated Implantation Failure. J Reprod Infertil (2019) 20(1):35–41.
    1. Dieamant F, Vagnini LD, Petersen CG, Mauri AL, Renzi A, Petersen B, et al. . New Therapeutic Protocol for Improvement of Endometrial Receptivity (PRIMER) for Patients With Recurrent Implantation Failure (RIF) - A Pilot Study. JBRA Assist Reprod (2019) 23(3):250–4. doi: 10.5935/1518-0557.20190035
    1. Nazari L, Salehpour S, Hosseini MS, Hashemi Moghanjoughi P. The Effects of Autologous Platelet-Rich Plasma in Repeated Implantation Failure: A Randomized Controlled Trial. Hum Fertil (Camb) (2020) 23(3):209–13. doi: 10.1080/14647273.2019.1569268
    1. Tehraninejad ES, Kashani NG, Hosseini A, Tarafdari A. Autologous Platelet-Rich Plasma Infusion Does Not Improve Pregnancy Outcomes in Frozen Embryo Transfer Cycles in Women With History of Repeated Implantation Failure Without Thin Endometrium. J Obstet Gynaecol Res (2021) 41(1):147–51. doi: 10.1111/jog.14445
    1. Zamaniyan M, Peyvandi S, Gorji HH, Moradi S, Jamal J, Yahya Poor Aghmashhadi F, et al. . Effect of Platelet-Rich Plasma on Pregnancy Outcomes in Infertile Women With Recurrent Implantation Failure: A Randomized Controlled Trial. Gynecol Endocrinol (2020) 2:1–5. doi: 10.1080/09513590.2020.1756247
    1. Tandulwadkar SR, Naralkar MV, Surana AD, Selvakarthick M, Kharat AH. Autologous Intrauterine Platelet-Rich Plasma Instillation for Suboptimal Endometrium in Frozen Embryo Transfer Cycles: A Pilot Study. J Hum Reprod Sci (2017) 10(3):208–12. doi: 10.4103/jhrs.JHRS_28_17
    1. Molina A, Sanchez J, Sanchez W, Vielma V. Platelet-Rich Plasma as an Adjuvant in the Endometrial Preparation of Patients With Refractory Endometrium. JBRA Assist Reprod (2018) 22(1):42–8. doi: 10.5935/1518-0557.20180009
    1. Kaur J, Madhavan A, Naidu P, Rani K, Mahajan N. Intrauterine Autologous Platelet-Rich Plasma Therapy to Improve Implantation Rates in Patients Undergoing Frozen Embryo Transfer: A Pilot Study. Onco Fertil J (2018) 1(2):81–5. doi: 10.4103/tofj.tofj_11_18
    1. Abdalla HI, Brooks AA, Johnson MR, Kirkland A, Thomas A, Studd JW. Endometrial Thickness: A Predictor of Implantation in Ovum Recipients? Hum Reprod (1994) 9(2):363–5. doi: 10.1093/oxfordjournals.humrep.a138509
    1. El-Toukhy T, Coomarasamy A, Khairy M, Sunkara K, Seed P, Khalaf Y, et al. . The Relationship Between Endometrial Thickness and Outcome of Medicated Frozen Embryo Replacement Cycles. Fertil Steril (2008) 89(4):832–9. doi: 10.1016/j.fertnstert.2007.04.031
    1. Gallos ID, Khairy M, Chu J, Rajkhowa M, Tobias A, Campbell A, et al. . Optimal Endometrial Thickness to Maximize Live Births and Minimize Pregnancy Losses: Analysis of 25,767 Fresh Embryo Transfers. Reprod BioMed Online (2018) 37(5):542–8. doi: 10.1016/j.rbmo.2018.08.025
    1. Gonen Y, Casper RF, Jacobson W, Blankier J. Endometrial Thickness and Growth During Ovarian Stimulation: A Possible Predictor of Implantation in In Vitro Fertilization. Fertil Steril (1989) 52(3):446–50. doi: 10.1016/s0015-0282(16)60916-0
    1. Kasius A, Smit JG, Torrance HL, Eijkemans MJ, Mol BW, Opmeer BC, et al. . Endometrial Thickness and Pregnancy Rates After IVF: A Systematic Review and Meta-Analysis. Hum Reprod Update (2014) 20(4):530–41. doi: 10.1093/humupd/dmu011
    1. Tomic V, Kasum M, Vucic K. Impact of Embryo Quality and Endometrial Thickness on Implantation in Natural Cycle Ivf. Arch Gynecol Obstetr (2020) 301(5):1325–30. doi: 10.1007/s00404-020-05507-4
    1. Kovacs P, Matyas S, Boda K, Kaali SG. The Effect of Endometrial Thickness on IVF/ICSI Outcome. Hum Reprod (2003) 18(11):2337–41. doi: 10.1093/humrep/deg461
    1. Kitaya K, Yasuo T. Immunohistochemistrical and Clinicopathological Characterization of Chronic Endometritis. Am J Reprod Immunol (2011) 66(5):410–5. doi: 10.1111/j.1600-0897.2011.01051.x
    1. Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez-Monfort M, Bau D, Vilella F, et al. . The Diagnosis of Chronic Endometritis in Infertile Asymptomatic Women: A Comparative Study of Histology, Microbial Cultures, Hysteroscopy, and Molecular Microbiology. Am J Obstet Gynecol (2018) 218(6):602.e1–602.e16. doi: 10.1016/j.ajog.2018.02.012
    1. Pietro CD, Cicinelli E, Guglielmino MR, Ragusa M, Farina M, Palumbo MA, et al. . Altered Transcriptional Regulation of Cytokines, Growth Factors, and Apoptotic Proteins in the Endometrium of Infertile Women With Chronic Endometritis. Am J Reprod Immunol (2013) 69(5):509–17. doi: 10.1111/aji.12076
    1. Cicinelli E, Matteo M, Tinelli R, Lepera A, Alfonso R, Indraccolo U, et al. . Prevalence of Chronic Endometritis in Repeated Unexplained Implantation Failure and the IVF Success Rate After Antibiotic Therapy. Hum Reprod (2015) 30(2):323–30. doi: 10.1093/humrep/deu292
    1. Johnston-MacAnanny EB, Hartnett J, Engmann LL, Nulsen JC, Sanders MM, Benadiva CA. Chronic Endometritis is a Frequent Finding in Women With Recurrent Implantation Failure After In Vitro Fertilization. Fertil Steril (2010) 93(2):437–41. doi: 10.1016/j.fertnstert.2008.12.131
    1. Romero R, Espinoza J, Mazor M. Can Endometrial Infection/Inflammation Explain Implantation Failure, Spontaneous Abortion, and Preterm Birth After In Vitro Fertilization? Fertil Steril (2004) 82(4):799–804. doi: 10.1016/j.fertnstert.2004.05.076
    1. Wu D, Kimura F, Zheng L, Ishida M, Niwa Y, Hirata K, et al. . Chronic Endometritis Modifies Decidualization in Human Endometrial Stromal Cells. Reprod Biol Endocrinol (2017) 15(1):16. doi: 10.1186/s12958-017-0233-x
    1. Kitaya K, Matsubayashi H, Takaya Y, Nishiyama R, Yamaguchi K, Takeuchi T, et al. . Live Birth Rate Following Oral Antibiotic Treatment for Chronic Endometritis in Infertile Women With Repeated Implantation Failure. Am J Reprod Immunol (2017) 78(5):e12719. doi: 10.1111/aji.12719
    1. Sfakianoudis K, Simopoulou M, Nitsos N, Lazaros L, Rapani A, Pantou A, et al. . Successful Implantation and Live Birth Following Autologous Platelet-Rich Plasma Treatment for a Patient With Recurrent Implantation Failure and Chronic Endometritis. In Vivo (2019) 33(2):515–21. doi: 10.21873/invivo.11504
    1. Li F, Cui Y, Zhao D, Bao H, Hao C. Outcome Study of Five Cases Receiving In Vitro Fertilization After Treatment of Intrauterine Platelet-Rich Plasma (PRP) for Chronic Endometritis. Panminerva Med (2021). doi: 10.23736/S0031-0808.20.04247-0
    1. Al-Inany H. Intrauterine Adhesions. An Update. Acta Obstet Gynecol Scand (2001) 80(11):986–93. doi: 10.1034/j.1600-0412.2001.801103.x
    1. March CM, Israel R, March AD. Hysteroscopic Management of Intrauterine Adhesions. Am J Obstet Gynecol (1978) 130(6):653–7. doi: 10.1016/0002-9378(78)90322-8
    1. Puente Gonzalo E, Alonso Pacheco L, Vega Jiménez A, Vitale SG, Raffone A, Laganà AS. Intrauterine Infusion of Platelet-Rich Plasma for Severe Asherman Syndrome: A Cutting-Edge Approach. Updates Surg (2020). doi: 10.1007/s13304-020-00828-0
    1. Aghajanova L, Cedars MI, Huddleston HG. Platelet-Rich Plasma in the Management of Asherman Syndrome: Case Report. J Assist Reprod Genet (2018) 35(5):771–5. doi: 10.1007/s10815-018-1135-3
    1. Aghajanova L, Houshdaran S, Balayan S, Manvelyan E, Irwin JC, Huddleston HG, et al. . In Vitro Evidence That Platelet-Rich Plasma Stimulates Cellular Processes Involved in Endometrial Regeneration. J Assist Reprod Genet (2018) 35(5):757–70. doi: 10.1007/s10815-018-1130-8
    1. Marini MG, Perrini C, Esposti P, Corradetti B, Bizzaro D, Riccaboni P, et al. . Effects of Platelet-Rich Plasma in a Model of Bovine Endometrial Inflammation In Vitro . Reprod Biol Endocrinol (2016) 14(1):58. doi: 10.1186/s12958-016-0195-4
    1. de Miguel-Gómez L, López-Martínez S, Campo H, Francés-Herrero E, Faus A, Díaz A, et al. . Comparison of Different Sources of Platelet-Rich Plasma as Treatment Option for Infertility-Causing Endometrial Pathologies. Fertil Steril (2020) 115(2):490–500. doi: 10.1016/j.fertnstert.2020.07.053
    1. Chien LW, Au HK, Chen PL, Xiao J, Tzeng CR. Assessment of Uterine Receptivity by the Endometrial-Subendometrial Blood Flow Distribution Pattern in Women Undergoing In Vitro Fertilization-Embryo Transfer. Fertil Steril (2002) 78(2):245–51. doi: 10.1016/s0015-0282(02)03223-5
    1. Friedler S, Schenker JG, Herman A, Lewin A. The Role of Ultrasonography in the Evaluation of Endometrial Receptivity Following Assisted Reproductive Treatments: A Critical Review. Hum Reprod Update (1996) 2(4):323–35. doi: 10.1093/humupd/2.4.323
    1. Miwa I, Tamura H, Takasaki A, Yamagata Y, Shimamura K, Sugino N. Pathophysiologic Features of "Thin" Endometrium. Fertil Steril (2009) 91(4):998–1004. doi: 10.1016/j.fertnstert.2008.01.029
    1. Smith SK. Angiogenesis, Vascular Endothelial Growth Factor and the Endometrium. Hum Reprod Update (1998) 4(5):509–19. doi: 10.1093/humupd/4.5.509
    1. Smith SK. Angiogenesis and Implantation. Hum Reprod (2000) 15 Suppl 6:59–66. doi: 10.1007/s10815-007-9152-7
    1. Segabinazzi LG, Friso AM, Correal SB, Crespilho AM, Dell'Aqua JA, Miro J, et al. . Uterine Clinical Findings, Fertility Rate, Leucocyte Migration, and COX-2 Protein Levels in the Endometrial Tissue of Susceptible Mares Treated With Platelet-Rich Plasma Before and After AI. Theriogenology (2017) 104:120–6. doi: 10.1016/j.theriogenology.2017.08.007
    1. Reghini MF, Ramires Neto C, Segabinazzi LG, Castro Chaves MM, Dell'Aqua Cde P, Bussiere MC, et al. . Inflammatory Response in Chronic Degenerative Endometritis Mares Treated With Platelet-Rich Plasma. Theriogenology (2016) 86(2):516–22. doi: 10.1016/j.theriogenology.2016.01.029
    1. Jang HY, Myoung SM, Choe JM, Kim T, Cheon YP, Kim YM, et al. . Effects of Autologous Platelet-Rich Plasma on Regeneration of Damaged Endometrium in Female Rats. Yonsei Med J (2017) 58(6):1195–203. doi: 10.3349/ymj.2017.58.6.1195
    1. Griffith OW, Chavan AR, Protopapas S, Maziarz J, Romero R, Wagner GP. Embryo Implantation Evolved From an Ancestral Inflammatory Attachment Reaction. Proc Natl Acad Sci U S A (2017) 114(32):E6566–75. doi: 10.1073/pnas.1701129114
    1. Mor G, Cardenas I, Abrahams V, Guller S. Inflammation and Pregnancy: The Role of the Immune System at the Implantation Site. Ann N Y Acad Sci (2011) 1221:80–7. doi: 10.1111/j.1749-6632.2010.05938.x
    1. Caley MP, Martins VL, O'Toole EA. Metalloproteinases and Wound Healing. Adv Wound Care (New Rochelle) (2015) 4(4):225–34. doi: 10.1089/wound.2014.0581
    1. Zhang S, Li P, Yuan Z, Tan J. Platelet-Rich Plasma Improves Therapeutic Effects of Menstrual Blood-Derived Stromal Cells in Rat Model of Intrauterine Adhesion. Stem Cell Res Ther (2019) 10(1):61. doi: 10.1186/s13287-019-1155-7
    1. Zhou Y, Shen H, Wu Y, Zhao X, Pei J, Mou Z, et al. . Platelet-Rich Plasma Therapy Enhances the Beneficial Effect of Bone Marrow Stem Cell Transplant on Endometrial Regeneration. Front Cell Dev Biol (2020) . 8:52. doi: 10.3389/fcell.2020.00052

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