Geroscience: linking aging to chronic disease

Brian K Kennedy, Shelley L Berger, Anne Brunet, Judith Campisi, Ana Maria Cuervo, Elissa S Epel, Claudio Franceschi, Gordon J Lithgow, Richard I Morimoto, Jeffrey E Pessin, Thomas A Rando, Arlan Richardson, Eric E Schadt, Tony Wyss-Coray, Felipe Sierra, Brian K Kennedy, Shelley L Berger, Anne Brunet, Judith Campisi, Ana Maria Cuervo, Elissa S Epel, Claudio Franceschi, Gordon J Lithgow, Richard I Morimoto, Jeffrey E Pessin, Thomas A Rando, Arlan Richardson, Eric E Schadt, Tony Wyss-Coray, Felipe Sierra

Abstract

Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.

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Figure 1
The Seven Pillars of Aging

Source: PubMed

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