Granulomatous Mastitis during Chronic Antidepressant Therapy: Is It Possible a Conservative Therapeutic Approach?

Maurizio Bellavia, Giuseppe Damiano, Vincenzo Davide Palumbo, Gabriele Spinelli, Giovanni Tomasello, Antonio Marrazzo, Silvia Ficarella, Antonio Bruno, Antonino Sammartano, Tiziana Fiorentini, Antonio Scio, Carolina Maione, Attilio Ignazio Lo Monte, Maurizio Bellavia, Giuseppe Damiano, Vincenzo Davide Palumbo, Gabriele Spinelli, Giovanni Tomasello, Antonio Marrazzo, Silvia Ficarella, Antonio Bruno, Antonino Sammartano, Tiziana Fiorentini, Antonio Scio, Carolina Maione, Attilio Ignazio Lo Monte

Abstract

Granulomatous mastitis is a rare benign inflammatory disease of the breast with multiple etiologies such as tuberculosis, sarcoidosis, foreign body reaction, and mycotic and parasitic infections. In contrast, idiopathic granulomatous mastitis (IGM) is characterized by the presence of chronic granulomatous lobulitis in the absence of an obvious etiology. Clinically and radiologically it may mimic breast carcinoma and so awareness of surgeons, pathologists, and radiologists is essential to avoid unnecessary mastectomies. Cases of IGM are reported during antidepressant therapy in patients also showing high levels of prolactinemia. In these cases, we believe that surgical excision must be avoided being replaced with a conservative management of the pathological condition based on a corticosteroid treatment.

Keywords: Antidepressant therapy; Hyperprolactinemia; Idiopathic granulomatous mastitis; Selective serotonin reuptake inhibitors.

Conflict of interest statement

The authors declare that they have no competing interests.

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Source: PubMed

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