Impact of analgesic techniques on early quality of recovery after prostatectomy: A 3-arm, randomized trial

Christian M Beilstein, Markus Huber, Marc A Furrer, Lukas M Löffel, Patrick Y Wuethrich, Dominique Engel, Christian M Beilstein, Markus Huber, Marc A Furrer, Lukas M Löffel, Patrick Y Wuethrich, Dominique Engel

Abstract

Background: Prostatectomy is associated with relevant acute postoperative pain. Optimal analgesic techniques to minimize pain and enhance recovery are still under investigation. We aimed to compare the effect of three different analgesic techniques on quality of recovery.

Methods: This investigator-initiated, prospective, randomized, three-arm, parallel-group, active-controlled, interventional superiority trial was performed in a Swiss teaching hospital from 2018 to 2021. Consecutive patients undergoing open or robotic-assisted radical prostatectomy were randomized to spinal anaesthesia (SSS, bupivacaine 0.5% + fentanyl), bilateral transversus abdominis plane block (TAP, ropivacaine 0.375% + clonidine) or systemic administration of lidocaine (SA, lidocaine 1%) in addition to general anaesthesia. Primary outcome was quality of recovery 15 (QoR-15) score on postoperative day one compared to baseline. Secondary outcomes were QoR-15 at discharge, postoperative nausea and vomiting, pain scores, return of gastrointestinal function and use of rescue analgesia.

Results: From 133 patients, 40 received spinal anaesthesia, 45 TAP block and 48 systemic analgesia. QoR-15 scores did not differ on day 1 (p = 0.301) or at discharge (p = 0.309) when compared to baseline. QoR-15 changes were similar in all groups. At discharge, median QoR-15 scores were considered as good (>122) in all groups: SSS 134 [IQR 128-138]; TAP 129 [IQR 122-136] and SA 128 [IQR 123-136]. There were no significant differences in the other secondary outcomes.

Conclusions: Quality of recovery on postoperative day one compared to baseline did not differ if spinal anaesthesia, TAP block or systemic administration of lidocaine was added to general anaesthesia.

Significance: Optimal analgesic techniques to enhance recovery after prostatectomy are still under investigation. In this 3-arm randomized controlled trial, addition of spinal anaesthesia or transversus abdominis plane block to general anaesthesia did not improve quality of recovery after radical prostatectomy compared to less invasive intravenous lidocaine infusion (standard of care/control group). Quality of recovery at the time of discharge was considered as good in all three groups.

Trial registration: ClinicalTrials.gov NCT03618693.

© 2022 The Authors. European Journal of Pain published by John Wiley & Sons Ltd on behalf of European Pain Federation - EFIC ®.

Figures

FIGURE 1
FIGURE 1
CONSORT flow chart.
FIGURE 2
FIGURE 2
Quality of recovery (QoR‐15) scores for the entire cohort (including patients undergoing open and robotic‐assisted radical prostatectomy). (a) Time series of QoR‐15 scores for time points preoperative, postoperative and discharge. Median and interquartile ranges are shown as well as individual patients as coloured lines. (b) Primary outcome: Change in QoR‐15 postoperative minus preoperative. Secondary outcome: Change in QoR‐15 at discharge minus preoperative. Exploratory outcome: Change in QoR‐15 discharge minus postoperative. Box and whisker plots are shown as well as individual patients as coloured dots. Global p‐values from a Kruskal‐Wallis rank sum test are shown. No post‐hoc between‐group comparisons were computed as the global p‐values were not statistically significant.
FIGURE 3
FIGURE 3
Box and whisker plot of the individual scores of the Quality of recovery (QoR‐15) questionnaire. Scores are shown for each treatment group (SSS, TAP and SA) for time points preoperative, postoperative and discharge. Coloured lines denote individual patients.

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