Effects of mirror neuron system-based training on rehabilitation of stroke patients

Huiwen Mao, Yan Li, Li Tang, Ye Chen, Jiawei Ni, Liang Liu, Chunlei Shan, Huiwen Mao, Yan Li, Li Tang, Ye Chen, Jiawei Ni, Liang Liu, Chunlei Shan

Abstract

Objective: To investigate the clinical effects of the mirror neuron system (MNS)-based training on upper extremity motor function and cognitive function in stroke patients.

Methods: Sixty stroke patients (time from stroke onset 3-9 months) with upper extremity paresis (Brunnstrom stage II-IV) and cognitive impairment (MoCA score ≥ 15) were enrolled in this study. Patients were randomly allocated into MNS treatment group (N = 30) and control group (N = 30). Both groups underwent regular training for upper extremity motor function and cognitive function, and the MNS group was trained with a therapeutic apparatus named mirror neuron system training (MNST) including different levels of action observation training (AOT). Training lasted 20 min/day, 5 days/week for 8 weeks. MoCA, reaction time, and Wisconsin Card Sorting Test (WCST) were assessed at baseline and 8 weeks after training. Furthermore, Fugl-Meyer assessment (FMA) and Modified Barthel index (MBI) were adopted to evaluated upper extremity motor function and daily life ability.

Results: After 8 consecutive weeks' training, both groups showed significant improvements on the upper extremity motor function, cognitive function, and daily life ability score after training (p < .05). The MNS group showed significantly improved upper extremity motor function and cognitive function (p < .05) compared with control group.

Conclusions: Combining MNS-based and conventional training can improve upper extremity motor function and cognitive function in stroke patients.

Keywords: cognitive function; mirror neuron system; stroke; training; upper extremity function.

Conflict of interest statement

None declared.

© 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC.

Figures

FIGURE 1
FIGURE 1
The Mirror Neuron System Training (MNST, V1.0, Suzhou MNST Medical Science and Technology Co., Ltd) machine and patient training status
FIGURE 2
FIGURE 2
Study Flowchart

References

    1. Aisen, M. L. , Krebs, H. I. , Hogan, N. , McDowell, F. , & Volpe, B. T. (1997). The effect of robot‐assisted therapy and rehabilitative training on motor recovery following stroke. Archives of Neurology, 54(4), 443–446. 10.1001/archneur.1997.00550160075019
    1. Brooks, B. M. , & Rose, F. D. (2003). The use of virtual reality in memory rehabilitation: Current findings and future directions. NeuroRehabilitation, 18, 147–157. 10.3233/NRE-2003-18207
    1. Buccino, G. , Solodkin, A. , & Small, S. L. (2006). Functions of the mirror neuron system: Implications for neurorehabilitation. Cognitive and Behavioral Neurology, 19(1), 55–63. 10.1097/00146965-200603000-00007
    1. Cauraugh, J. H. , & Kim, S. B. (2002). Two coupled motor recovery protocols are better than one: Electromyogram triggered neuromuscular stimulation and bilateral movements. Stroke, 33(6), 1589–1594. 10.1161/01.STR.0000016926.77114.A6
    1. Chen, W. , Ye, Q. , Ji, X. , Zhang, S. , Yang, X. , Zhou, Q. , … Shan, C. (2015). Mirror neuron system based therapy for aphasia rehabilitation. Frontiers in Psychology, 6, 1665 10.3389/fpsyg.2015.01665
    1. Cui, S. , Ren, M. , Du, Y. , Liu, Y. , & Zhang, L. (2014). Analysis of the effects of computer assisted training on cognitive impairment after stroke. Chinese Clinical Study, 1, 21–23.
    1. Huang, L. , & Yang, Q. (2014). The effects of the electric stimulation of percutaneous acupuncture on limb dysfunction in hemiplegia after cerebral infarction. Journal of Physical Medicine and Rehabilitation, 38(1), 49–51.
    1. Iacoboni, M. , & Dapretto, M. (2006). The mirror neuron system and the consequences of its dysfunction. Nature Reviews Neuroscience, 7(12), 942–951. 10.1038/nrn2024
    1. Kilgore, K. L. , Peckham, P. H. , Keith, M. W. , Montague, F. W. , Hart, R. L. , Gazdik, M. M. , … Stage, T. G. (2003). Durability of implanted electrodes and leads in an upper extremity neuron prosthesis. The Journal of Rehabilitation Research and Development, 40(6), 457–468.
    1. Li, J. , & Tian, B. (2005). The theoretical model physiological mechanism and application of sports imagination. Journal of Wuhan Institute Sport, 39(5), 64–67.
    1. Liu, L. , & Feng, Z. (2012). Clinical research and application progress of myoelectric biofeedback. Journal of Physical Medicine and Rehabilitation, 27(3), 60–62.
    1. Luber, B. , & Lisanby, S. H. (2014). Enhancement of human cognitive performance using transcranial magnetic stimulation (TMS). NeuroImage, 85, 961–970. 10.1016/j.neuroimage.2013.06.007
    1. Ni, H. , Hu, Y. , Cui, X. , Huang, D. , Qu, P. , Wang, J. , & Shi, J. (2012). The clinical efficacy of cudgel in prevention of post‐stroke shoulder ‐ hand syndrome. Chinese Journal of Rehabilitation Theory and Practice, 18(6), 524–526.
    1. Rizzolatti, G. , & Craighero, L. (2004). The mirror‐neuron system. Annual Review of Neuroscience, 27, 169–192. 10.1146/annurev.neuro.27.070203.144230
    1. Sale, P. , & Franceschini, M. (2012). Action observation and mirror neuron network: A tool for motor stroke rehabilitation. European Journal of Physical and Rehabilitation Medicine, 48, 313–318.
    1. Serrano, S. , Domingo, J. , Rodriguez‐Garcia, E. , Castro, M. D. , & del Ser, T. (2007). Frequency of cognitive impairment without dementia in patients with stroke: A two‐year follow‐up study. Stroke, 38(1), 105–110. 10.1161/01.STR.0000251804.13102.c0
    1. Small, S. L. , Buccino, G. , & Solodkin, A. (2012). The mirror neuron system and treatment of stroke. Developmental Psychobiology, 54, 293–310.
    1. Wang, L. , Feng, X. , Liu, C. , Wang, X. , Sun, W. , Liu, Y. , & Niu, Y. (2015). Effects of temperature acupuncture on cognitive impairment after stroke. Chinese Journal of Rehabilitation Theory and Practice, 21(2), 199–201.
    1. Wang, W. , Zhang, X. , Ji, X. , Ye, Q. , Chen, W. , Ni, J. , … Shan, C. (2015). Mirror neuron therapy for hemispatial neglect patients. Scientific Reports, 5, 8664 10.1038/srep08664
    1. Xu, L. , & Wu, Y. (2007). Application of virtual reality technology in hand function recovery in stroke patients. Journal of Physical Medicine and Rehabilitation, 29(2), 136–138.
    1. Zhang, T. , & Ma, D. (2013). Analysis of prognostic factors in stroke patients. Medicine Reviews, 13(5), 385–386.

Source: PubMed

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