Ten years of kala-azar in west Bengal, Part I. Did post-kala-azar dermal leishmaniasis initiate the outbreak in 24-Parganas?

Abstract

Following resurgence in Bihar of epidemic kala-azar, outbreaks of the disease were identified simultaneously in two separate foci about 500 km apart in West Bengal in 1980. While the outbreak in one of these foci, in northern West Bengal, was the result of a direct extension of the Bihar epidemic, the source of parasite in the other (in the village of Bandipur in the south of West Bengal) remained unknown until a case of nodulo-ulcerative post-kala-azar dermal leishmaniasis (PKDL) was located in the village. The continued presence of this case in the village from a time long before the outbreak aroused strong suspicion about its causal role. Laboratory-bred female Phlebotomus argentipes sandflies were allowed to feed on four cases of PKDL, including the case from Bandipur, to determine the transmission potential of these cases. Of a total of 400 flies in the experiment, 104 (26%) fed on the cases, and of these flies 44 died (31 within 48 hours of feeding). Of the surviving 60 flies, 32 developed promastigotes in the mid-gut. In view of the presence of the case of PKDL in the village prior to the outbreak and the availability of a susceptible human population and vectors, it is possible that the patient with PKDL was a source of Leishmania donovani parasites for the local focus. Furthermore, PKDL may act as a reservoir of parasites during inter-epidemic periods.