Anti-inflammatory effects of low-dose radiotherapy. Indications, dose, and radiobiological mechanisms involved

M Arenas, S Sabater, V Hernández, A Rovirosa, P C Lara, A Biete, J Panés, M Arenas, S Sabater, V Hernández, A Rovirosa, P C Lara, A Biete, J Panés

Abstract

Low-dose radiotherapy (LD-RT) has been used for several benign diseases, including arthrodegenerative and inflammatory pathologies. Despite its effectiveness in clinical practice, little is known about the mechanisms through which LD-RT modulates the various phases of the inflammatory response and about the optimal dose fractionation. The objective of this review is to deepen knowledge about the most effective LD-RT treatment schedule and radiobiological mechanisms underlying the anti-inflammatory effects of LD-RT in various in vitro experiments, in vivo studies, and clinical studies.

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