Fallout from the COVID-19 pandemic - should we prepare for a tsunami of post viral depression?

D Lyons, M Frampton, S Naqvi, D Donohoe, G Adams, K Glynn, D Lyons, M Frampton, S Naqvi, D Donohoe, G Adams, K Glynn

Abstract

The current COVID-19 pandemic is not just a medical and social tragedy, but within the threat of the outbreak looms the potential for a significant and persistent negative mental health impact, based on previous experience with other pandemics such as Severe Acute Respiratory Syndrome (SARS) in 2003 and the earlier H1N1 outbreak of 1918. This piece will highlight the links between depression and viral illnesses and explore important overlaps with myalgic encephalomyelitis/chronic fatigue syndrome, potentially implicating inflammatory mechanisms in those exposed to a range of viral agents. While containment of psychological distress currently focuses on social anxiety and quarantine measures, a second wave of psychological morbidity due to viral illness may be imminent.

Keywords: COVID-19; Coronavirus; major depressive disorder; myalgic encephalomyelitis.

References

    1. Beiner G (2006). Out in the cold and back-new found interest in the great flu. Culture and Social History 3, 496–505.
    1. Benros ME, Waltoft BL, Nordentoft M, Ostergaard SD, Eaton WW, Krogh J, Mortensen PB (2013). Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study. JAMA Psychiatry 70 (8), 812–820.
    1. Blazer DG, Hybels CF (2005). Origins of depression in later life. Psychological Medicine 35, 1–12.
    1. Booth CM, Matukas LM, Tomlinson GA, et al. (2003). Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA 289 (21), 2801–2809.
    1. Brooks SK, Webster R, Smith L, Woodland L, Wessely S, Greenberg N (2020). The psychological impact of quarantine and how reduce it: rapid review of the evidence. The Lancet 395 (10227), 912–920.
    1. Canli T (2014). Reconceptualizing major depressive disorder as an infectious disease. Biology of Mood and Anxiety Disorders 4 (10). doi: 10.1186/2045-5380-4-10.
    1. Chu L, Valencia IJ, Garvert DW, Montoya JG (2019). Onset, patterns and course of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Frontiers in Pediatrics 7 (12). doi: 10.3389fped.2019.00012.
    1. Coughlin SS (2012). Anxiety and depression: linkages with viral diseases. Public Health Reviews 34 (7). doi: 10.1007/BF03391675.
    1. Dantzer R (2001). Cytokine induced sickness behavior: where do we stand? Brain Behavior and Immunity 15, 7–24.
    1. Dinos S, Khoshaba B, Ashby D, White PD, Nazroo J, Wessely S, Bhui KS (2009). A systematic review of chronic fatigue, it’s syndromes and ethnicity: prevalence, severity, co-morbidity and coping. International Journal of Epidemiology 38 (6), 1554–1570.
    1. Dumit J (2006). Illnesses you have to fight to get: facts as forces in uncertain, emergent illnesses. Social Science & Medicine 62 (3), 577–590.
    1. Eisenberger NL, Berkman ET, Inagaki TK, Rameson LT, Mashal NM, Irwin MR (2010). Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biological Psychiatry 68 (8), 748–754.
    1. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A (1994). The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Annals of Internal Medicine 121, 953–959. doi: 10.7326/0003-4819-121-12-199412150-00009.
    1. Gale SD, Berrett AN, Erickson LD, Brown BL, Hedges DW (2018). Psychiatry Research 261, 73–79.
    1. Gelder M, Mayou R, Cowen P (2001). Shorter Oxford Textbook of Psychiatry. Oxford University Press: New York.
    1. Herridge MS, Cheung AM, Tansey CM, et al. (2003). One-year outcomes in survivors of the acute respiratory distress syndrome. The New England Journal of Medicine 348, 683–693.
    1. Holmes GP, Kaplan JE, Stewart JA, Hunt B, Pinsky PF, Schonberger LB (1987). A cluster of patients with a chronic mononucleosis-like syndrome. Is Epstein-Barr virus the cause? JAMA 257, 2297–2302.
    1. Holmes KK, Bertozzi S, Bloom BR, Jha P, Gelband H, DeMaria LM, Horton S (2017). Major infectious diseases: key messages from disease control priorities In Major Infectious Diseases, 3rd edn. (ed. Holmes K. K., Bertozzi S., Bloom B. R. and Jha P.) Chapter 1. The International Bank for Reconstruction and Development/The World Bank: Washington, DC.
    1. Howren MB, Lamkin DM, Suls J (2009). Associations of depression with C-reactive protein, IL-1 and IL-6: a meta-analysis. Psychosomatic Medicine 71 (2), 171–186.
    1. Irani S, Lang B (2008). Autoantibody-mediated disorders of the central nervous system. Autoimmunity 41 (1), 55–65.
    1. Johnston S, Brenu EW, Staines D, Marshall-Gradisnik S (2013). The prevalence of chronic fatigue syndrome/myalgic encephalomyelitis: a meta-analysis. Clinical Epidemiology 5, 105–110.
    1. Lievesley K, Rimes KA, Chalder T (2014). A review of the predisposing and perpetuating factors in Chronic Fatigue Syndrome in children and adolescents. Clinical Psychology Review 34 (3), 233–248.
    1. Mamelund SE (2010). The impact of influenza on mental health in Norway 1872–1929. Workshop May 2010. Carlsberg Academy, Copenhagen Denmark (). Accessed 16 April 2020.
    1. Manjunatha N, Math SB, Kulkami GB, Chaturvedi SK (2011). The neuropsychiatric aspects of infuluenza/swine flu: a selective review. Industrial Psychiatry Journal 20 (2), 83–90.
    1. Martin WJ (1997). Detection of RNA sequences in cultures of a stealth virus isolated from the cerebrospinal fluid of a health care worker with chronic fatigue syndrome. Case report. Pathobiology 65, 57–60.
    1. Menninger KA (1919). Psychoses associated with influenza. I: general data. Statistical analysis. JAMA 72, 235–241.
    1. Moldofsky H, Patcai J (2011). Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case controlled study. BMC Neurology 11, 37. doi: 10.1186/1471-2377-11-37.
    1. Okusaga O, Yolken R, Langenberg P, et al. (2011). Association with seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts. Journal of Affective disorders 130 (1–2), 220–225.
    1. Pivonello R, Simeoli C, Cristina de Martino M, et al. (2015). Neuropsychiatric disorders in Cushing’s syndrome. Frontiers in Neuroscience 9, 129. Published online 2015 Apr 20. doi: 10.3389/fnins.2015.00129.
    1. Rasa S, Nora-Krukle Z, Henning N, Eliassen E, Shikova E, Harrer T, Scheibenbogen C, Murovska M, Prusty BK (2018). Chronic viral infections in myalgic encepaholmyelitis/chronic fatigue syndrome. Journal of Translational Medicine 16 (268). doi: 10.1186/s12967-018-1644-y.
    1. Straus SE, Tosato G, Armstrong G, et al. (1985). Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection. Annals of Internal Medicine 102, 7–16.
    1. Unger ER, Lin JS, Brimmer DJ, Lapp CW, Komaroff AL, Nath A, Laird S, Iskander J (2016). CDC grand rounds: chronic fatigue syndrome- advancing research and clinical education. MMWR Morbidity and Mortality Weekly Report 65 (50–51), 1434–1438.
    1. Van den Heuvel L, Chishinga N, Kinyanda E, et al. (2013). Frequency and correlates of anxiety and mood disorder among TB- and HIV-infected Zambians. AIDS Care 25, 12; 1527–1535.
    1. Vollmer-Conna U (2001). Acute sickness behavior: an immune system to brain communication. Psychological Medicine 31, 761–767.
    1. Wang X, Zhang L, Lei Y, et al. (2015). Meta-analysis of infectious agents and depression. Scientific Reports 4, 4530. doi: 10.1038/srep04530.
    1. Wojcik W, Armstrong D, Kanaan R (2011). Chronic fatigue syndrome: labels, meanings and consequences. Journal of Psychosomatic Research 70 (6), 500–504.
    1. Xu J, Zhong S, Liu J, et al. (2005). Detection of severe acute respiratory syndrome corona virus in the brain: potential role of chemokine migration in pathogenesis. Clinical Infectious Diseases 41, 1089–1096.

Source: PubMed

3
Suscribir