Consistently high estimates for the proportion of human exposure to malaria vector populations occurring indoors in rural Africa

Bernadette Huho, Olivier Briët, Aklilu Seyoum, Chadwick Sikaala, Nabie Bayoh, John Gimnig, Fredros Okumu, Diadier Diallo, Salim Abdulla, Thomas Smith, Gerry Killeen, Bernadette Huho, Olivier Briët, Aklilu Seyoum, Chadwick Sikaala, Nabie Bayoh, John Gimnig, Fredros Okumu, Diadier Diallo, Salim Abdulla, Thomas Smith, Gerry Killeen

Abstract

Background: Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are highly effective tools for controlling malaria transmission in Africa because the most important vectors, from the Anopheles gambiae complex and the A. funestus group, usually prefer biting humans indoors at night.

Methods: Matched surveys of mosquito and human behaviour from six rural sites in Burkina Faso, Tanzania, Zambia, and Kenya, with ITN use ranging from 0.2% to 82.5%, were used to calculate the proportion of human exposure to An. gambiae sensu lato and An. funestus s.l. that occurs indoors (πi), as an indicator of the upper limit of personal protection that indoor vector control measures can provide. This quantity was also estimated through use of a simplified binary analysis (π(i)(B)) so that the proportions of mosquitoes caught indoors (Pi), and between the first and last hours at which most people are indoors (Pfl) could also be calculated as underlying indicators of feeding by mosquitoes indoors or at night, respectively.

Results: The vast majority of human exposure to Anopheles bites occurred indoors (π(i)(B)= 0.79-1.00). Neither An. gambiae s.l. nor An. funestus s.l. strongly preferred feeding indoors (P(i) = 0.40-0.63 and 0.22-0.69, respectively), but they overwhelmingly preferred feeding at times when most humans were indoors (P(fl) = 0.78-1.00 and 0.86-1.00, respectively).

Conclusions: These quantitative summaries of behavioural interactions between humans and mosquitoes constitute a remarkably consistent benchmark with which future observations of vector behaviour can be compared. Longitudinal monitoring of these quantities is vital to evaluate the effectiveness of ITNs and IRS and the need for complementary measures that target vectors outdoors.

Figures

Figure 1
Figure 1
Map of Africa showing locations of study sites
Figure 2
Figure 2
Hourly biting pattern of Anopheles gambiae sensu lato (panels on left) and Anopheles funestus sensu lato (panels on right) occurring both indoors (solid lines) and outdoors (dashed lines) at different study sites. The grey area represents the proportion of the human population predominantly spending time indoors during the times shown on the abscissa of each graph
Figure 3
Figure 3
Profiles of biting by both Anopheles gambiae sensu latu (panels on left) and Anopheles funestus sensu lato (panels on right) experienced by human population at different study sites. Pie charts illustrate the amount of exposure occurring indoors and outdoors. The light grey areas in the graphs and pie charts represent outdoor human exposure and the dark grey areas represent indoor human exposure

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