Heart rate variability biofeedback: how and why does it work?

Paul M Lehrer, Richard Gevirtz, Paul M Lehrer, Richard Gevirtz

Abstract

In recent years there has been substantial support for heart rate variability biofeedback (HRVB) as a treatment for a variety of disorders and for performance enhancement (Gevirtz, 2013). Since conditions as widely varied as asthma and depression seem to respond to this form of cardiorespiratory feedback training, the issue of possible mechanisms becomes more salient. The most supported possible mechanism is the strengthening of homeostasis in the baroreceptor (Vaschillo et al., 2002; Lehrer et al., 2003). Recently, the effect on the vagal afferent pathway to the frontal cortical areas has been proposed. In this article, we review these and other possible mechanisms that might explain the positive effects of HRVB.

Keywords: baroreflex; biofeedback; heart rate variability; homeostasis; resonance.

Figures

FIGURE 1
FIGURE 1
A typical HRVB screen showing the transition from normal breathing to 7 breaths per minute breathing.
FIGURE 2
FIGURE 2
N250 (in microvolts) evoked potential during various conditions.
FIGURE 3
FIGURE 3
Heart rate variability as measured by SDNN across sessions for the heart rate variability biofeedback group compared to the EMG/relaxation group.
FIGURE 4
FIGURE 4
Heartbeat event related potential (HEP) at 250 μs for both groups pre vs. post-training (sign reversed).

References

    1. Ahmad S., Tejuja A., Newman K. D., Zarychanski R., Seely A. J. (2009). Clinical review: a review and analysis of heart rate variability and the diagnosis and prognosis of infection. Crit. Care 13:232 10.1186/cc8132
    1. Arnold A. C., Shaltout H. A., Gallagher P. E., Diz D. I. (2009). Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension 54 1001–1008 10.1161/HYPERTENSIONAHA.109.138065
    1. Badra L. J., Cooke W. H., Hoag J. B., Crossman A. A., Kuusela T. A., Tahvanainen K. U., et al. (2001). Respiratory modulation of human autonomic rhythms. Am. J. Physiol. Heart Circ. Physiol. 280 H2674–H2688
    1. Başar E. (1998). “Resonance phenomena in the brain, physical systems, and nature,” in Brain Functions and Oscillations ed.Başar E. (Berlin: Springer Verlag; ). 10.1007/978-3-642-72192-2
    1. Berntson G. G., Bigger J. T., Jr., Eckberg D. L., Grossman P., Kaufmann P. G., Malik M., et al. (1997). Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology 34 623–648 10.1111/j.1469-8986.1997.tb02140.x
    1. Borovikova L. V., Ivanova S., Zhang M., Yang H., Botchkina G. I., Watkins L. R., et al. (2000). Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405 458–462 10.1038/35013070
    1. Boutcher S. H., Park Y., Dunn S. L., Boutcher Y. N. (2013). The relationship between cardiac autonomic function and maximal oxygen uptake response to high-intensity intermittent-exercise training. J. Sports Sci. 31 1024–1029 10.1080/02640414.2012.762984
    1. Brown R. P., Gerbarg P. L. (2005a). Sudarshan Kriya Yogic breathing in the treatment of stress, anxiety, and depression. Part II – clinical applications and guidelines. J. Altern. Complement. Med. 11 711–717 10.1089/acm.2005.11.711
    1. Brown R. P., Gerbarg P. L. (2005b). Sudarshan Kriya yogic breathing in the treatment of stress, anxiety, and depression: part I-neurophysiologic model. J. Altern. Complement. Med. 11 189–201 10.1089/acm.2005.11.189
    1. Brown R. P., Gerbarg P. L., Muench F. (2013). Breathing practices for treatment of psychiatric and stress-related medical conditions. Psychiatr. Cliin. North Am. 36 121–140 10.1016/j.psc.2013.01.001
    1. Brown T. E., Beightol L. A., Koh J., Eckberg D. L. (1993). Important influence of respiration on human R-R interval power spectra is largely ignored. J. Appl. Physiol. 75 2310–2317
    1. Carney R. M., Freedland K. E. (2009). Depression and heart rate variability in patients with coronary heart disease. Cleve. Cliin. J. Med. 76(Suppl. 2), S13–S17 10.3949/ccjm.76.s2.03
    1. Chan C. T. (2008). Heart rate variability in patients with end-stage renal disease: an emerging predictive tool for sudden cardiac death? Nephrol. Dial. Transplant. 23 3061–3062 10.1093/ndt/gfn280
    1. Christensen J. H. (2012). Cardiac autonomic dysfunction in hemodialysis patients assessed by heart rate variability. Minerva Urol. Nefrol. 64 191–198 10.1111/j.1542-4758.2011.00529.x
    1. Cristancho P., Cristancho M. A., Baltuch G. H., Thase M. E., O’Reardon J. P. (2011). Effectiveness and safety of vagus nerve stimulation for severe treatment-resistant major depression in Clinical practice after FDA approval: outcomes at 1 year. J. Clin. Psychiatry 72 1376–1382 10.4088/JCP.09m05888blu
    1. Critchley H. D., Wiens S., Rotshtein P., Ohman A., Dolan R. J. (2004). Neural systems supporting interoceptive awareness. Nat. Neurosci. 7 189–195 10.1038/nn1176
    1. Daban C., Martinez-Aran A., Cruz N., Vieta E. (2008). Safety and efficacy of Vagus Nerve Stimulation in treatment-resistant depression. A systematic review. J. Affect. Disord. 110 1–15 10.1016/j.jad.2008.02.012
    1. De Meersman R. E. (1993). Heart rate variability and aerobic fitness. Am. Heart. J. 125 726–731 10.1016/0002-8703(93)90164-5
    1. Eckberg D. L. (2003). The human respiratory gate. J. Physiol. 548(Pt 2), 339–352 10.1113/jphysiol.2002.037192
    1. Eckberg D. L., Nerhed C., Wallin B. G. (1985). Respiratory modulation of muscle sympathetic and vagal cardiac outflow in man. J. Physiol. 365181–196
    1. Eckberg D. L., Sleight P. (1992). Human Baroreflexes in Health and Disease. Oxford: Clarendon Press
    1. Fleisher L. A., Frank S. M., Sessler D. I., Cheng C., Matsukawa T., Vannier C. A. (1996). Thermoregulation and heart rate variability. Clin. Sci. 90 97–103
    1. Friedman B. H., Thayer J. F. (1998). Autonomic balance revisited: panic anxiety and heart rate variability. J. Psychosom. Res. 44 133–151 10.1016/S0022-3999(97)00202-X
    1. Fukusaki C., Kawakubo K., Yamamoto Y. (2000). Assessment of the primary effect of aging on heart rate variability in humans. Clin. Auton. Res. 10 123–130 10.1007/BF02278016
    1. George M. S., Ward H. E., Jr., Ninan P. T., Pollack M., Nahas Z., Anderson B., et al. (2008). A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders. Brain Stimul. 1 112–121 10.1016/j.brs.2008.02.001
    1. Gevirtz R. (2013). The promise of heart rate variability biofeedback: evidence-based applications. Biofeedback 41 110–120 10.5298/1081-5937-41.3.01
    1. Gevirtz R., Hubbard D., Harpin E. (1996). Psychophysiologic treatment of chronic low back pain. Prof. Psychol. Res. Pract. 27 561–566 10.1037/0735-7028.27.6.561
    1. Giardino N. D., Chan L., Borson S. (2004). Combined heart rate variability and pulse oximetry biofeedback for chronic obstructive pulmonary disease: preliminary findings. Appl. Psychophysiol. Biofeedback 29 121–133 10.1023/B:APBI.0000026638.64386.89
    1. Gorman J. M., Sloan R. P. (2000). Heart rate variability in depressive and anxiety disorders. Am. Heart. J. 140(4 Suppl.), 77–83 10.1067/mhj.2000.109981
    1. Gray M. A., Taggart P., Sutton P. M., Groves D., Holdright D. R., Bradbury D., et al. (2007). A cortical potential reflecting cardiac function. Proc. Natl. Acad. Sci. U.S.A. 104 6818–6823 10.1073/pnas.0609509104
    1. Grossman P., Karemaker J., Wieling W. (1991). Prediction of tonic parasympathetic cardiac control using respiratory sinus arrhythmia: the need for respiratory control. Psychophysiology 28 201–216 10.1111/j.1469-8986.1991.tb00412.x
    1. Grundy D. (2002). Neuroanatomy of visceral nociception: vagal and splanchnic afferent. Gut 51(Suppl. 1), i2–i5 10.1136/gut.51.suppl_1.i2
    1. Handa R., Poanta L., Rusu D., Albu A. (2012). The role of heart rate variability in assessing the evolution of patients with chronic obstructive pulmonary disease. Rom. J. Intern. Med. 50 83–88
    1. Hautala A. J., Makikallio T. H., Kiviniemi A., Laukkanen R. T., Nissila S., Huikuri H. V., et al. (2003). Cardiovascular autonomic function correlates with the response to aerobic training in healthy sedentary subjects. Am. J. Physiol. Heart Circ. Physiol. 285 H1747–H1752 10.1152/ajpheart.00202.2003
    1. Hayano J., Yasuma F., Okada A., Mukai S., Fujinami T. (1996). Respiratory sinus arrhythmia: a phenomenon improving pulmonary gas exchange and circulatory efficiency. Circulation 94 842–847 10.1161/01.CIR.94.4.842
    1. Henderson L. A., Richard C. A., Macey P. M., Runquist M. L., Yu P. L., Galons J. P., et al. (2004). Functional magnetic resonance signal changes in neural structures to baroreceptor reflex activation. J. Appl. Physiol. 96 693–703 10.1152/japplphysiol.00852.2003
    1. Henriques G., Keffer S., Abrahamson C., Horst S. J. (2011). Exploring the effectiveness of a computer-based heart rate variability biofeedback program in reducing anxiety in college students. Appl. Psychophysiol. Biofeedback 36 101–112 10.1007/s10484-011-9151-4
    1. Huang C., Gevirtz R., Onton J., Criado J. (2014). Investigation of vagal afferent functioning using heartbeat event related potentials. Paper Presented at the 45th Annual Meeting of the Association for Applied Psychophysiology and Biofeedback Savannah, GA
    1. Hobson A. R., Furlong P. L., Aziz Q. (2008). Oesophageal afferent pathway sensitivity in non-erosive reflux disease. Neurogastroenterol. Motil. 20 877–883 10.1111/j.1365-2982.2008.01122.x
    1. Hubbard D. (1998). Persistent muscular pain: approaches to relieving trigger points. J. Musculoskelat. Med. 15 16–26
    1. Hubbard D. R., Berkoff G. M. (1993). Myofascial trigger points show spontaneous needle EMG activity. Spine 18 1803–1807 10.1097/00007632-199310000-00015
    1. Huikuri H. V., Perkiomaki J. S., Maestri R., Pinna G. D. (2009). Clinical impact of evaluation of cardiovascular control by novel methods of heart rate dynamics. Philos. Trans. R. Soc. Lond. A Math. Phys. Eng. Sci. 367 1223–1238 10.1098/rsta.2008.0294
    1. Huikuri H. V., Stein P. K. (2013). Heart rate variability in risk stratification of cardiac patients. Prog. Cardiovasc. Dis. 56 153–159 10.1016/j.pcad.2013.07.003
    1. Ivanov P. C., Amaral L. A., Goldberger A. L., Havlin S., Rosenblum M. G., Struzik Z. R., et al. (1999). Multifractality in human heartbeat dynamics. Nature 399 461–465 10.1038/20924
    1. Karavidas M. K., Lehrer P. M., Vaschillo E., Vaschillo B., Marin H., Buyske S., et al. (2007). Preliminary results of an open label study of heart rate variability biofeedback for the treatment of major depression. Appl. Psychophysiol. Biofeedback 32 19–30 10.1007/s10484-006-9029-z
    1. Kemp A. H., Quintana D. S., Gray M. A., Felmingham K. L., Brown K., Gatt J. M. (2010). Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biol. Psychiatry 67 1067–1074 10.1016/j.biopsych.2009.12.012
    1. Kudaiberdieva G., Gorenek B., Timuralp B. (2007). Heart rate variability as a predictor of sudden cardiac death. Anadolu. Kardiyol. Derg. 7(Suppl. 1),68–70
    1. Laitio T., Jalonen J., Kuusela T., Scheinin H. (2007). The role of heart rate variability in risk stratification for adverse postoperative cardiac events. Anesth. Analg. 105 1548–1560 10.1213/01.ane.0000287654.49358.3a
    1. Lehrer P., Eddie D. (2013). Dynamic processes in regulation and some implications for biofeedback and biobehavioral interventions. Appl. Psychophysiol. Biofeedback 38 143–155 10.1007/s10484-013-9217-6
    1. Lehrer P., Karavidas M. K., Lu S.-E., Coyle S. M., Oikawa L. O., Macor M., et al. (2010). Voluntarily produced increases in heart rate variability modulate autonomic effects of endotoxin induced systemic inflammation: an exploratory study. Appl. Psychophysiol. Biofeedback 35 303–315 10.1007/s10484-010-9139-5
    1. Lehrer P. M., Vaschillo E., Vaschillo B. (2000). Resonant frequency biofeedback training to increase cardiac variability: rationale and manual for training. Appl. Psychophyisol. Biofeedback 25 177–191 10.1023/A:1009554825745
    1. Lehrer P. M., Vaschillo E., Vaschillo B., Lu S. E., Eckberg D. L., Edelberg R., et al. (2003). Heart rate variability biofeedback increases baroreflex gain and peak expiratory flow. Psychosom. Med. 65 796–805 10.1097/01.PSY.0000089200.81962.19
    1. Lehrer P., Sasaki Y., Saito Y. (1999). Zazen and cardiac variability. Psychosom. Med. 61 812–821 10.1097/00006842-199911000-00014
    1. Lehrer P., Vaschillo E., Trost Z., France C. R. (2009). Effects of rhythmical muscle tension at 0.1 Hz on cardiovascular resonance and the baroreflex. Biol. Psychol. 81 24–30 10.1016/j.biopsycho.2009.01.003
    1. Lin G., Xiang Q., Fu X., Wang S., Wang S., Chen S., et al. (2012). Heart rate variability biofeedback decreases blood pressure in prehypertensive subjects by improving autonomic function and baroreflex. J. Altern. Complement. Med. 18 143–152 10.1089/acm.2010.0607
    1. MacKinnon S., Gevirtz R., McCraty R., Brown M. (2013). Utilizing heartbeat evoked potentials to identify cardiac regulation of vagal afferents during emotion and resonant breathing. Appl. Psychophysiol. Biofeedback 38 241–255 10.1007/s10484-013-9226-5
    1. Marchal F., Schweitzer C., Moreau-Colson C. (2002). Respiratory impedance response to a deep inhalation in children with history of cough or asthma. Pediatr. Pulmonol. 33 411–418 10.1002/ppul.10093
    1. Matsumoto T., Miyawaki T., Ue H., Kanda T., Zenji C., Moritani T. (1999). Autonomic responsiveness to acute cold exposure in obese and non-obese young women. Int. J. Obes. Relat. Metab. Disord. 23 793–800 10.1038/sj.ijo.0800928
    1. McCraty R., Atkinson M., Lipsenthal L., Arguelles L. (2009). New hope for correctional officers: an innovative program for reducing stress and health risks. Appl. Psychophysiol. Biofeedback 34 251–272 10.1007/s10484-009-9087-0
    1. McNarry M. A., Lewis M. J. (2012). Interaction between age and aerobic fitness in determining heart rate dynamics. Physiol. Meas. 33 901–914 10.1088/0967-3334/33/6/901
    1. Montoya P., Schandry R., Muller A. (1993). Heartbeat evoked potentials (HEP): topography and influence of cardiac awareness and focus of attention. Electroencephalogr. Clin. Neurophysiol. 88 163–172 10.1016/0168-5597(93)90001-6
    1. Nada P. J. (2009). Heart rate variability in the assessment and biofeedback training of common mental health problems in children. Med. Arh. 63 244–248
    1. Nahas Z., Marangell L. B., Husain M. M., Rush A. J., Sackeim H. A., Lisanby S. H., et al. (2005). Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes. J. Cliin. Psychiatry 66 1097–1104 10.4088/JCP.v66n0902
    1. Nolan R. P., Floras J. S., Ahmed L., Harvey P. J., Hiscock N., Hendrickx H., et al. (2012). Behavioural modification of the cholinergic anti-inflammatory response to c-reactive protein in patients with hypertension. J. Intern. Med. 272 161–169 10.1111/j.1365-2796.2012.02523.x
    1. Nolan R. P., Floras J. S., Harvey P. J., Kamath M. V., Picton P. E., Chessex C., et al. (2010). Behavioral neurocardiac training in hypertension: a randomized, controlled trial. Hypertension 55 1033–1039 10.1161/HYPERTENSIONAHA.109.146233
    1. Nunan D., Sandercock G. R., Brodie D. A. (2010). A quantitative systematic review of normal values for short-term heart rate variability in healthy adults. Pacing Clin. Electrophysiol. 33 1407–1417 10.1111/j.1540-8159.2010.02841.x
    1. Olshansky B., Sabbah H. N., Hauptman P. J., Colucci W. S. (2008). Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy. Circulation 118 863–871 10.1161/CIRCULATIONAHA.107.760405
    1. Otsuka K., Cornelissen G., Halberg F. (1997). Circadian rhythmic fractal scaling of heart rate variability in health and coronary artery disease. Clin. Cardiol. 20 631–638 10.1002/clc.4960200710
    1. Passino C., Sleight P., Valle F., Spadacini G., Leuzzi S., Bernardi L. (1997). Lack of peripheral modulation of cardiovascular central oscillatory autonomic activity during apnea in humans. Am. J. Physiol. 272(1Pt 2), H123–H129
    1. Patron E., Messerotti Benvenuti S., Favretto G., Valfre C., Bonfa C., Gasparotto R., et al. (2013). Biofeedback assisted control of respiratory sinus arrhythmia as a biobehavioral intervention for depressive symptoms in patients after cardiac surgery: a preliminary study. Appl. Psychophysiol. Biofeedback 38 1–9 10.1007/s10484-012-9202-5
    1. Paul M., Garg K. (2012). The effect of heart rate variability biofeedback on performance psychology of basketball players. Appl. Psychophysiol. Biofeedback 37 131–144 10.1007/s10484-012-9185-2
    1. Pellegrino R., Violante B., Brusasco V. (1996). Maximal bronchoconstriction in humans. Relationship to deep inhalation and airway sensitivity. Am. J. Respir. Crit. Care Med. 153 115–121 10.1164/ajrccm.153.1.8542103
    1. Pikkujamsa S. M., Makikallio T. H., Sourander L. B., Raiha I. J., Puukka P., Skytta J., et al. (1999). Cardiac interbeat interval dynamics from childhood to senescence : comparison of conventional and new measures based on fractals and chaos theory. Circulation 100 393–399 10.1161/01.CIR.100.4.393
    1. Politano L., Palladino A., Nigro G., Scutifero M., Cozza V. (2008). Usefulness of heart rate variability as a predictor of sudden cardiac death in muscular dystrophies. Acta Myol. 27 114–122
    1. Pollatos O., Kirsch W., Schandry R. (2005a). Brain structures involved in interoceptive awareness and cardioafferent signal processing: a dipole source localization study. Hum. Brain Mapp. 26 54–64 10.1002/hbm.20121
    1. Pollatos O., Kirsch W., Schandry R. (2005b). On the relationship between interoceptive awareness, emotional experience, and brain processes. Brain Res. Cogn. Brain Res. 25 948–962 10.1016/j.cogbrainres.2005.09.019
    1. Polson J. W., Dampney R. A., Boscan P., Pickering A. E., Paton J. F. (2007). Differential baroreflex control of sympathetic drive by angiotensin II in the nucleus tractus solitarii. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 R1954–R1960 10.1152/ajpregu.00041.2007
    1. Porges S. (2011). The Polyvagal theory. New York: W. W. Norton & Company
    1. Ranpuria R., Hall M., Chan C. T., Unruh M. (2008). Heart rate variability (HRV) in kidney failure: measurement and consequences of reduced HRV. Nephrol. Dial. Transplant. 23 444–449 10.1093/ndt/gfm634
    1. Raven P. B., Potts J. T., Shi X. (1997). Baroreflex regulation of blood pressure during dynamic exercise. Exerc. Sport Sci. Rev. 25 365–389 10.1249/00003677-199700250-00015
    1. Reiner R. (2008). Integrating a portable biofeedback device into Clinical practice for patients with anxiety disorders: results of a pilot study. Appl. Psychophysiol. Biofeedback 33 55–61 10.1007/s10484-007-9046-6
    1. Rogers R. F., Rybak I. A., Schwaber J. S. (2000). Computational modeling of the baroreflex arc: nucleus tractus solitarius. Brain Res. Bull. 51 139–150 10.1016/S0361-9230(99)00242-7
    1. Sackeim H. A., Keilp J. G., Rush A. J., George M. S., Marangell L. B., Dormer J. S., et al. (2001a). The effects of vagus nerve stimulation on cognitive performance in patients with treatment-resistant depression. Neuropsychiatry Neuropsychol. Behav. Neurol. 14 53–62
    1. Sackeim H. A., Rush A. J., George M. S., Marangell L. B., Husain M. M., Nahas Z., et al. (2001b). Vagus nerve stimulation (VNS) for treatment-resistant depression: efficacy, side effects, and predictors of outcome. Neuropsychopharmacology 25 713–728 10.1016/S0893-133X(01)00271-8
    1. Schandry R. (1981). Heart beat perception and emotional experience. Psychophysiology 18 483–488 10.1111/j.1469-8986.1981.tb02486.x
    1. Schandry R. (2003). [From the heart to the brain]. Deutsch. Med. Wochenschr. 128 2707–2711 10.1055/s-2003-812550
    1. Schandry R., Sparrer B., Weitkunat R. (1986). From the heart to the brain: a study of heartbeat contingent scalp potentials. Int. J. Neurosci. 30 261–275 10.3109/00207458608985677
    1. Shaw L. (2011). Setting the balance: assessment of a biofeedback intervention for improving competitive performance with a Division 1 gymnastics beam team. Diss. Abstr. Int. B Sci. Eng. 71:4496
    1. Siepmann M., Aykac V., Unterdorfer J., Petrowski K., Mueck-Weymann M. (2008). A pilot study on the effects of heart rate variability biofeedback in patients with depression and in healthy subjects. Appl. Psychophysiol. Biofeedback 33 195–201 10.1007/s10484-008-9064-z
    1. Skinner J. E., Anchin J. M., Weiss D. N. (2008a). Nonlinear analysis of the heartbeats in public patient ECGs using an automated PD2i algorithm for risk stratification of arrhythmic death. Ther. Cliin. Risk Manag. 4549–557
    1. Skinner J. E., Meyer M., Dalsey W. C., Nester B. A., Ramalanjaona G., O’Neil B. J., et al. (2008b). Risk stratification for arrhythmic death in an emergency department cohort: a new method of nonlinear PD2i analysis of the ECG. Ther. Clin. Risk Manag. 4 689–697
    1. Skinner J. E., Meyer M., Nester B. A., Geary U., Taggart P., Mangione A., et al. (2009). Comparison of linear-stochastic and nonlinear-deterministic algorithms in the analysis of 15-minute Clinical ECGs to predict risk of arrhythmic death. Ther. Clin. Risk Manag. 5 671–682 10.2147/TCRM.S5568
    1. Song H. S., Lehrer P. M. (2003). The effects of specific respiratory rates on heart rate and heart rate variability. Appl. Psychophysiol. Biofeedback 28 13–24 10.1023/A:1022312815649
    1. Srinivasan K., Ashok M., Vaz M., Yeragani V. K. (2002). Decreased chaos of heart rate time series in children of patients with panic disorder. Depress. Anxiety 15 159–167 10.1002/da.10046
    1. Stein K. M. (2008). Noninvasive risk stratification for sudden death: signal-averaged electrocardiography, nonsustained ventricular tachycardia, heart rate variability, baroreflex sensitivity, and QRS duration. Prog. Cardiovasc. Dis. 51 106–117 10.1016/j.pcad.2007.10.001
    1. Strack B. W. (2003). Effect of heart rate variability (hrv) biofeedback on batting performance in baseball. Diss. Abstr. Int. B Sci. Eng. 64:1540
    1. Strauss-Blasche G., Moser M., Voica M., McLeod D. R., Klammer N., Marktl W. (2000). Relative timing of inspiration and expiration affects respiratory sinus arrhythmia. Clin. Exp. Pharmacol. Physiol. 27 601–606 10.1046/j.1440-1681.2000.03306.x
    1. Tan G., Dao T. K., Farmer L., Sutherland R. J., Gevirtz R. (2011). Heart rate variability (HRV) and posttraumatic stress disorder (PTSD): a pilot study. Appl. Psychophysiol. Biofeedback 36 27–35 10.1007/s10484-010-9141-y
    1. Thayer J. F., Nabors-Oberg R., Sollers J. J., III (1997). Thermoregulation, and cardiac variability: a time-frequency analysis. Biomed. Sci. Instrum. 34 252–256
    1. Thayer J. F., Yamamoto S. S., Brosschot J. F. (2010). The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int. J. Cardiol. 141 122–131 10.1016/j.ijcard.2009.09.543
    1. Tracey K. J. (2002). The inflammatory reflex. Nature 420 853–859 10.1038/nature01321
    1. Valentini M., Parati G. (2009). Variables influencing heart rate. Prog. Cardiovasc. Dis. 52 11–19 10.1016/j.pcad.2009.05.004
    1. Van de Louw A., Médigue C., Papelier Y., Landrain M., Cottin F. (2010). Role of brainstem centers in cardiorespiratory phase difference during mechanical ventilation. Respir. Physiol. Neurobiol. 174 119–127 10.1016/j.resp.2010.04.014
    1. Vaschillo E. G., Bates M. E., Vaschillo B., Lehrer P., Udo T., Mun E. Y., et al. (2008). Heart rate variability response to alcohol, placebo, and emotional picture cue challenges: effects of 0.1-Hz stimulation. Psychophysiology 45 847–858 10.1111/j.1469-8986.2008.00673.x
    1. Vaschillo E. G., Vaschillo B., Buckman J. F., Pandina R. J., Bates M. E. (2012). Measurement of vascular tone and stroke volume baroreflex gain. Psychophysiology 49 193–197 10.1111/j.1469-8986.2011.01305.x
    1. Vaschillo E. G., Vaschillo B., Lehrer P. M. (2006). Characteristics of resonance in heart rate variability stimulated by biofeedback. Appl. Psychophysiol. Biofeedback 31 129–142 10.1007/s10484-006-9009-3
    1. Vaschillo E. G., Vaschillo B., Pandina R. J., Bates M. E. (2011). Resonances in the cardiovascular system caused by rhythmical muscle tension. Psychophysiology 48 927–936 10.1111/j.1469-8986.2010.01156.x
    1. Vaschillo E., Lehrer P., Rishe N., Konstantinov M. (2002). Heart rate variability biofeedback as a method for assessing baroreflex function: a preliminary study of resonance in the cardiovascular system. Appl. Psychophysiol. Biofeedback 27 1–27 10.1023/A:1014587304314
    1. Volz H. P., Rehbein G., Triepel J., Knuepfer M. M., Stumpf H., Stock G. (1990). Afferent connections of the nucleus centralis amygdalae. A horseradish peroxidase study and literature survey. Anat. Embryol. 181 177–194 10.1007/BF00198957
    1. Wang S. Z., Li S., Xu X. Y., Lin G. P., Shao L., Zhao Y., et al. (2010). Effect of slow abdominal breathing combined with biofeedback on blood pressure and heart rate variability in prehypertension. J. Altern. Complement. Med. 16 1039–1045 10.1089/acm.2009.0577
    1. Weaver R. L., Lobkis O. I. (2006). On the linewidth of the ultrasonic Larsen effect in a reverberant body. J. Acoust. Soc. Am. 120 102–109 10.1121/1.2205128
    1. Yeragani V. K., Rao K., Smitha M., Pohl R. B., Balon R., Srinivasan K. (2002). Diminished chaos of heart rate time series in patients with major depression. Biol. Psychiatry 51 733–744 10.1016/S0006-3223%2801%2901347-6
    1. Zucker T. L., Samuelson K. W., Muench F., Greenberg M. A., Gevirtz R. N. (2009). The effects of respiratory sinus arrhythmia biofeedback on heart rate variability and posttraumatic stress disorder symptoms: a pilot study. Appl. Psychophysiol. Biofeedback 34 135–143 10.1007/s10484-009-9085-2

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