Self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis: A randomized controlled study

Geraldine Martorella, Kenneth Mathis, Hongyu Miao, Duo Wang, Lindsey Park, Hyochol Ahn, Geraldine Martorella, Kenneth Mathis, Hongyu Miao, Duo Wang, Lindsey Park, Hyochol Ahn

Abstract

Background: Knee osteoarthritis (OA) is a leading cause of pain in older adults. Previous studies indicated clinic-based transcranial direct current stimulation (tDCS) was effective to reduce pain in various populations, but no published studies have reported the efficacy of home-based self-administered tDCS in older adults with knee OA using a randomized clinical study.

Objective: The purpose of this study was to evaluate the efficacy and feasibility of tDCS on clinical pain intensity in adults with knee OA pain.

Methods: One hundred twenty participants aged 50-85 years with knee OA pain were randomly assigned to receive fifteen daily sessions of 2 mA tDCS for 20 min (n = 60) or sham tDCS (n = 60) over 3 weeks with remote supervision via telehealth. Clinical pain intensity was measured by the Numeric Rating Scale and Western Ontario and McMaster Universities Osteoarthritis Index. Also, we collected data on the tDCS experience via a questionnaire.

Results: Participants (68% female) had a mean age of 66 years. Active tDCS significantly reduced pain intensity compared to sham tDCS after completion of the fifteen daily sessions (Cohen's d = 1.20; p-value < 0.0001). Participants showed high levels of satisfaction with their tDCS experience, and there have been no adverse events.

Conclusion: We demonstrated that home-based self-administered tDCS was feasible and reduced clinical pain intensity in older adults with knee OA, which can increase its accessibility. Future studies with multi-site randomized controlled trials are needed to validate our findings.

Trial registration: ClinicalTrials.gov Identifier NCT04016272.

Keywords: Acceptability; Efficacy; Feasibility; Knee osteoarthritis; Pain; Transcranial direct current stimulation.

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Figures

Fig. 1.
Fig. 1.
Study flow diagram.
Fig. 2.
Fig. 2.
Numeric rating score changes. SD: standard deviation, SE: standard error.
Fig. 3.
Fig. 3.
WOMAC score changes. SD: standard deviation, SE: standard error.

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