Isolation of Nontuberculous Mycobacteria in Southeast Asian and African Human Immunodeficiency Virus-infected Children With Suspected Tuberculosis
Laurence Borand, Agathe de Lauzanne, Ngoc Lan Nguyen, Sokleaph Cheng, Thu Hang Pham, Sara Eyangoh, Abdoul-Salam Ouedraogo, Vibol Ung, Philippe Msellati, Mathurin Tejiokem, Boubacar Nacro, Malin Inghammar, Bunnet Dim, Christophe Delacourt, Sylvain Godreuil, Stéphane Blanche, Olivier Marcy, Pediatric Asian African Network for Tuberculosis and HIV Research (PAANTHER) Study Group, Laurence Borand, Agathe de Lauzanne, Ngoc Lan Nguyen, Sokleaph Cheng, Thu Hang Pham, Sara Eyangoh, Abdoul-Salam Ouedraogo, Vibol Ung, Philippe Msellati, Mathurin Tejiokem, Boubacar Nacro, Malin Inghammar, Bunnet Dim, Christophe Delacourt, Sylvain Godreuil, Stéphane Blanche, Olivier Marcy, Pediatric Asian African Network for Tuberculosis and HIV Research (PAANTHER) Study Group
Abstract
We enrolled 427 human immunodeficiency virus-infected children (median age, 7.3 years), 59.2% severely immunodeficient, with suspected tuberculosis in Southeast Asian and African settings. Nontuberculous mycobacteria were isolated in 46 children (10.8%); 45.7% of isolates were Mycobacterium avium complex. Southeast Asian origin, age 5-9 years, and severe immunodeficiency were independently associated with nontuberculous mycobacteria isolation.
Clinical trials registration: NCT01331811.
Keywords: HIV; children; nontuberculous mycobacteria; tuberculosis.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
References
- López-Varela E, García-Basteiro AL, Santiago B, Wagner D, van Ingen J, Kampmann B. Non-tuberculous mycobacteria in children: muddying the waters of tuberculosis diagnosis. Lancet Respir Med 2015; 3:244–56.
- Griffith DE, Aksamit T, Brown-Elliott BA, et al. . ATS Mycobacterial Diseases Subcommittee; American Thoracic Society; Infectious Disease Society of America An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007; 175:367–416.
- Henkle E, Winthrop KL. Nontuberculous mycobacteria infections in immunosuppressed hosts. Clin Chest Med 2015; 36:91–9.
- Prevots DR, Marras TK. Epidemiology of human pulmonary infection with nontuberculous mycobacteria: a review. Clin Chest Med 2015; 36:13–34.
- McCarthy KD, Cain KP, Winthrop KL, et al. . Nontuberculous mycobacterial disease in patients with HIV in Southeast Asia. Am J Respir Crit Care Med 2012; 185:981–8.
- Marcy O, Ung V, Goyet S, et al. . Performance of Xpert MTB/RIF and alternative specimen collection methods for the diagnosis of tuberculosis in HIV-infected children. Clin Infect Dis 2016; 62:1161–8.
- Bonnet M, San KC, Pho Y, et al. . Nontuberculous mycobacteria infections at a provincial reference hospital, Cambodia. Emerg Infect Dis 2017; 23:1139–47.
- Hatherill M, Hawkridge T, Whitelaw A, et al. . Isolation of non-tuberculous mycobacteria in children investigated for pulmonary tuberculosis. PLoS One 2006; 1:e21.
- López-Varela E, García-Basteiro AL, Augusto OJ, et al. . High rates of non-tuberculous mycobacteria isolation in Mozambican children with presumptive tuberculosis. PLoS One 2017; 12:e0169757.
- Asiimwe BB, Bagyenzi GB, Ssengooba W, et al. . Species and genotypic diversity of non-tuberculous mycobacteria isolated from children investigated for pulmonary tuberculosis in rural Uganda. BMC Infect Dis 2013; 13:88.
- Hoza AS, Mfinanga SG, Rodloff AC, Moser I, König B. Increased isolation of nontuberculous mycobacteria among TB suspects in northeastern Tanzania: public health and diagnostic implications for control programmes. BMC Res Notes 2016; 9:109.
- Marcy O, Tejiokem M, Msellati P, et al. . ANRS 12229 PAANTHER 01 Study Group Mortality and its determinants in antiretroviral treatment-naive HIV-infected children with suspected tuberculosis: an observational cohort study. Lancet HIV 2018; 5:e87–95.
Source: PubMed