Association of Long-term Exercise Training With Risk of Falls, Fractures, Hospitalizations, and Mortality in Older Adults: A Systematic Review and Meta-analysis

Abstract

Importance: Long-term exercise benefits on prevalent adverse events in older populations, such as falls, fractures, or hospitalizations, are not yet established or known.

Objective: To systematically review and investigate the association of long-term exercise interventions (≥1 year) with the risk of falls, injurious falls, multiple falls, fractures, hospitalization, and mortality in older adults.

Data sources: PubMed, Cochrane Central Register of Controlled Trials, SportDiscus, PsychInfo, and Ageline were searched through March 2018.

Study selection: Exercise randomized clinical trials (RCTs) with intervention length of 1 year or longer, performed among participants 60 years or older.

Data extraction and synthesis: Two raters independently screened articles, abstracted the data, and assessed the risk of bias. Data were combined with risk ratios (RRs) using DerSimonian and Laird's random-effects model (Mantel-Haenszel method).

Main outcomes and measures: Six binary outcomes for the risk of falls, injurious falls, multiple falls (≥2 falls), fractures, hospitalization, and mortality.

Results: Forty-six studies (22 709 participants) were included in the review and 40 (21 868 participants) in the meta-analyses (mean [SD] age, 73.1 [7.1] years; 15 054 [66.3%] of participants were women). The most used exercise was a multicomponent training (eg, aerobic plus strength plus balance); mean frequency was 3 times per week, about 50 minutes per session, at a moderate intensity. Comparator groups were often active controls. Exercise significantly decreased the risk of falls (n = 20 RCTs; 4420 participants; RR, 0.88; 95% CI, 0.79-0.98) and injurious falls (9 RTCs; 4481 participants; RR, 0.74; 95% CI, 0.62-0.88), and tended to reduce the risk of fractures (19 RTCs; 8410 participants; RR, 0.84; 95% CI, 0.71-1.00; P = .05). Exercise did not significantly diminish the risk of multiple falls (13 RTCs; 3060 participants), hospitalization (12 RTCs; 5639 participants), and mortality (29 RTCs; 11 441 participants). Sensitivity analyses provided similar findings, except the fixed-effect meta-analysis for the risk of fracture, which showed a significant effect favoring exercisers (RR, 0.84; 95% CI, 0.70-1.00; P = .047). Meta-regressions on mortality and falls suggest that 2 to 3 times per week would be the optimal exercise frequency.

Conclusions and relevance: Long-term exercise is associated with a reduction in falls, injurious falls, and probably fractures in older adults, including people with cardiometabolic and neurological diseases.

Conflict of interest statement

Conflict of Interest Disclosures. Dr Rolland reports grants from Novartis and Lactalis and fees from Nestlé and Daxter. Dr Vellas reports Scientific Board Memberships for Acadia, Accera, Alzhéon, Biogen, Lilly, Lundbeck, MSD, Nestlé, Roche, Sanofi, Transition Therapeutics, Takeda, Otsuka, and Schwabe; and also Gerontopôle Research Grants from Abbvie, Lilly, Lundbeck, MSD, Otsuka, Pierre-Fabre, Régénéron, Roche, Sanofi, Alzheon, Astra-Zénéca, LPG Systems, and Nestlé. No other conflicts are reported.

Figures

Figure 1.. Association of Exercise on the Risk of Mortality and Hospitalization

Association of exercise with risk of mortality (A) and hospitalization (B). Weights are from random effects analysis.

Figure 2.. Association of Exercise on the Risk of Becoming a Faller and a Faller With Multiple Falls

Association of exercise with risk of becoming a faller (A) and becoming a multiple faller (B). Weights are from random effects analysis.

Figure 3.. Association of Exercise on the Risk of Becoming an Injurious Faller and Sustaining a Fracture

Association of exercise with risk of becoming an injurious faller (A) and sustaining a fracture (B). Weights are from random effects analysis.