Coronavirus Disease 2019 (COVID-19): A Perspective from China
Zi Yue Zu, Meng Di Jiang, Peng Peng Xu, Wen Chen, Qian Qian Ni, Guang Ming Lu, Long Jiang Zhang, Zi Yue Zu, Meng Di Jiang, Peng Peng Xu, Wen Chen, Qian Qian Ni, Guang Ming Lu, Long Jiang Zhang
Abstract
In December 2019, an outbreak of severe acute respiratory syndrome coronavirus 2 infection occurred in Wuhan, Hubei Province, China, and spread across China and beyond. On February 12, 2020, the World Health Organization officially named the disease caused by the novel coronavirus as coronavirus disease 2019 (COVID-19). Because most patients infected with COVID-19 had pneumonia and characteristic CT imaging patterns, radiologic examinations have become vital in early diagnosis and the assessment of disease course. To date, CT findings have been recommended as major evidence for clinical diagnosis of COVID-19 in Hubei, China. This review focuses on the etiology, epidemiology, and clinical symptoms of COVID-19 while highlighting the role of chest CT in prevention and disease control.
© RSNA, 2020.
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References
- Huang C, Wang Y, Li X, et al. . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020 Jan 24. pii: S0140-6736(20)30183-5. doi: 10.1016/S0140-6736(20)30183-5. [Epub ahead of print]
- Zhu N, Zhang D, Wang W, et al. . A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020 Jan 24. doi: 10.1056/NEJMoa2001017. [Epub ahead of print]
- Li Q, Guan X, Wu P, et al. . Early transmission dynamics in Wuhan, China, of novel coronavirus-Infected pneumonia. N Engl J Med 2020 Jan 29. doi:10.1056/NEJMoa2001316. [Epub ahead of print]
- Phan LT, Nguyen TV, Luong QC, et al. . Importation and human-to-human transmission of a novel coronavirus in vietnam. NEJM. January 28, 2020. doi: 10.1056/NEJMc2001272. [Epub ahead of print]
- Holshue ML, DeBolt C, Lindquist S, et al. . First case of 2019 novel coronavirus in the United States. N Engl J Med. 2020 Jan 31. doi: 10.1056/NEJMoa2001191. [Epub ahead of print]
- Giovanetti M, Benvenuto D, Angeletti S, Ciccozzi M. The first two cases of 2019-nCoV in Italy: where they come from? J Med Virol. 2020 Feb 5. doi: 10.1002/jmv.25699. [Epub ahead of print]
- Wu F, Zhao S, Yu B, et al. . A new coronavirus associated with human respiratory disease in China. Nature. 2020 Feb 3. doi: 10.1038/s41586-020-2008-3. [Epub ahead of print]
- World Health Organization . Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). 2020. at . Published January 31, 2020.
- World Health Organization . WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. 2020. at . Published February 11, 2020.
- World Health Organization . Coronavirus Disease 2019(COVID-19): situation report—30. 2020. . Published February 20, 2020. Accessed February 20, 2020
- Chinese Society of Radiology . Radiological diagnosis of new coronavirus infected pneumonitis: Expert recommendation from the Chinese Society of Radiology (First edition). Chin J Radiol, 2020,54(00): E001-E001. DOI: 10.3760/cma.j.issn.1005-1201.2020.0001.
- Chan JF, Yuan S, Kok KH, et al. . A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020 Jan 24. pii:S0140-6736(20)30154-9. doi: 10.1016/S0140-6736(20)30154-9. [Epub ahead of print]
- General Office of National Health Committee . Office of state administration of traditional Chinese medicine. Notice on the issuance of a programme for the diagnosis and treatment of novel coronavirus (2019-nCoV) infected pneumonia (trial fifth edition) (2020-02-26)[EB/OL].
- Kanne JP. Chest CT findings in 2019 novel coronavirus (2019-nCoV) infections from Wuhan, China: key points for the radiologist. Radiology. 2020 Feb 4:200241. doi:10.1148/radiol.2020200241. [Epub ahead of print]
- Pan Y, Guan H. Imaging changes in patients with 2019-nCov. Eur Radiol. 2020 Feb 6. doi:10.1007/s00330-020-06713-z. [Epub ahead of print]
- Ng M, Lee EYP, Yang J, et al. . Imaging profile of the COVID-19 infection: Radiologic findings and literature review. Radiology: Cardiothoracic Imaging 2020;2(1):e200034. doi:10.1148/ryct.2020200034
- Lu R, Zhao X, Li J, et al. . Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 Jan 30:S0140-6736(20)30251-8. doi: 10.1016/S0140-6736(20)30251-8. [Epub ahead of print]
- Wang Q, Wang YH, Ma JC, et al. . Description of the first strain of 2019-nCoV, C-Tan-nCoV Wuhan Strain — National Pathogen Resource Center, China, 2020. 2020. at .
- Kirchdoerfer RN, Cottrell CA, Wang N, et al. . Pre-fusion structure of a human coronavirus spike protein. Nature. 2016; 531(7592):118–121. doi: 10.1038/nature17200.
- Xu X, Chen P, Wang J, et al. . Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci. 2020 Jan 21. doi: 10.1007/s11427-020-1637-5. [Epub ahead of print]
- Gorbalenya AE, Baker SC, Baric RS, et al. . Severe acute respiratory syndrome-related coronavirus: the species and its viruses – a statement of the coronavirus study group. bioRxiv preprint first posted online February 11, 2020. 2020:2020.2002.2007.937862. doi:10.1101/2020.02.07.937862. Accessed February 12, 2020.
- Lam TTY, Shum MHH, Zhu HC, et al. . Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China. bioRxiv preprint first posted online February 18, 2020. 2020:2020.2002.2013.945485. doi: 10.1101/2020.02.13.945485. Accessed February 20, 2020.
- Zhang L, Shen FM, Chen F, Lin Z. Origin and evolution of the 2019 novel coronavirus. Clin Infect Dis. 2020 Feb 3:ciaa112. doi: 10.1093/cid/ciaa112. [Epub ahead of print]
- Wu Han health committee . Notice on the issuance of unexplained viral pneumonia [EB/OL]. 2020. .] Published January 3, 2020. Accessed February 8, 2020.
- Yang Y, Lu Q, Liu M, et al. . Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China. 10.1101/2020.02.10.20021675. Accessed February 13, 2020.
- Guan WJ, Ni ZY, Hu Y, et al. . Clinical characteristics of 2019 novel coronavirus infection in China. 10.1101/2020.02.06.20020974. Accessed February 13, 2020.
- Zhou P, Yang XL, Wang XG, et al. . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 Feb 3. doi: 10.1038/s41586-020-2012-7. [Epub ahead of print]
- Chen HJ, Guo JJ, Wang C, et al. . Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The Lancet. doi:10.1016/s0140-6736(20)30360-3. [Epub ahead of print]
- Rothe C, Schunk M, Sothmann P, et al. . Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. NEngl J Med. 2020 Jan 30. doi:10.1056/NEJMc2001468. [Epub ahead of print]
- World Health Organization . Novel coronavirus(2019-nCoV): situation report—12. 2020. . Published February 1, 2020. Accessed February 10,2020.
- Chen N, Zhou M, Dong X,et al. . Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020Jan 30. pii: S0140-6736(20)30211-7. doi: 10.1016/S0140-6736(20)30211-7. [Epub ahead of print]
- Wang D, Hu B, Hu C, et al. . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020 Feb 7. doi:10.1001/jama.2020.1585. [Epub ahead of print]
- World Health Organization . Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected. 2019. At . Accessed February 11, 2020.
- General Office of National Health Committee . Office of State Administration of Traditional Chinese Medicine. Notice on the issuance of a program for the diagnosis and treatment of novel coronavirus (2019-nCoV) infected pneumonia (trial sixth edition) (2020-02-19) [EB/OL]. ]
- World Health Organization . WHO guidelines for the global surveillance of severe acute respiratory syndrome (SARS). 2004. at . Published January, 2004. Updated October, 2004.
- World Health Organization . Middle East respiratory syndrome case definition for reporting to WHO. 2017. .
- Azhar EI,El-Kafrawy SA, Farraj SA, et al. . Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med 2014; 370(26): 2499-505.
- World Health Organization . Coronavirus Disease 2019(COVID-19): situation report—28. 2020. . Published February 18, 2020. Accessed February 20, 2020
- World Health Organization . Home care for patients with suspected novel coronavirus (nCoV) infection presenting with mild symptoms and management of contacts [EB/OL]. . Published January 20, 2020. Accessed February 11, 2020
- Pan F, Ye T, Sun P, et al. . Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia. Radiology 2020:200370. doi:10.1148/radiol.2020200370. Published February 1, 2020. Accessed February 13, 2020.
- Chung M, Bernheim A, Mei X, et al. . CT imaging features of 2019 novel coronavirus (2019-nCoV). Radiology. 2020 Feb 4:200230. doi:10.1148/radiol.2020200230. [Epub ahead ofprint]
- Song F, Shi N, Shan F, et al. . Emerging coronavirus 2019-nCoV pneumonia. Radiology 2020:200274. doi: 10.1148/radiol.2020200274
- Pan Y, Guan H, Zhou S,et al. . Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China. European Radiology 2020. doi: 10.1007/s00330-020-06731-x. [Epub ahead of print]
- Liu T, Huang P, Liu H, et al. . Spectrum of chest CT findings in a familial cluster of COVID-19 infection. Radiology: Cardiothoracic Imaging 2020;2(1):e200025. doi:10.1148/ryct.2020200025. Published February 1, 2020. Accessed February 13, 2020.
- Liu P, Tan XZ. 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology 2020:200257. doi: 10.1148/radiol.2020200257
- Lin X, GongZ, Xiao Z, Xiong J, Fan B, Liu J. Novel coronavirus pneumonia outbreakin2019: computed tomographicfindings in twocases. Korean J Radiol 2020;21. doi: 10.3348/kjr.2020.0078
- Lei J, Li J, Li X, Qi X. CT imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology 2020:200236. doi: 10.1148/radiol.2020200236 48.
- Fang Y, Zhang H, Xu Y, Xie J, Pang P, Ji W. CT manifestations of two cases of 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology 2020:200280. doi: 10.1148/radiol.2020200280
- Kong W, Agarwal PP. Chest imaging appearance of COVID-19 infection. Radiology: Cardiothoracic Imaging. 2020;2(1):e200028. doi: 10.1148/ryct.2020200028. Published February 1, 2020. Accessed February 13, 2020.
- Li X, Zeng X, Liu B, Yu Y. COVID-19 infection presenting with CT halo sign. Radiology: Cardiothoracic Imaging 2020;2(1):e200026. doi: 10.1148/ryct.2020200026. Published February 1, 2020. Accessed February 13, 2020.
- Shi H, Han X, Zheng C. Evolution of CT manifestations in a patient recovered from 2019 novel coronavirus (2019-nCoV) pneumonia in Wuhan, China. Radiology 2020:200269. doi: 10.1148/radiol.2020200269
- Duan YN, Qin J. Pre- and posttreatment chest CT findings: 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology 2020:200323. doi: 10.1148/radiol.2020200323
- Wu Y, Xie Yl, Wang X. Longitudinal CT findings in COVID-19 pneumonia: Case presenting organizing pneumonia pattern. Radiology: Cardiothoracic Imaging 2020;2(1):e200031. doi: 10.1148/ryct.2020200031. [Epub ahead of print]
- Qian L, Yu J, Shi H. Severe acute respiratory disease in a Huanan seafood market worker: Images of an early casualty. Radiology: Cardiothoracic Imaging 2020;2(1):e200033. doi: 10.1148/ryct.2020200033. [Epub ahead of print]
- Kim H. Outbreak of novel coronavirus (COVID-19): What is the role of radiologists? Eur Radiol 2020. doi: 10.1007/s00330-020-06748-2. [Epub ahead of print]
- Lee KS. Pneumonia associated with 2019 novel coronavirus: can computed tomographic findings help predict the prognosis of the disease? Korean J Radiol 2020;21. 10.3348/kjr.2020.0096
- Franquet T. Imaging of pulmonary viral pneumonia. Radiology 2011; 260(1): 18-39. doi: 10.1148/radiol.11092149.
- Hansell DM, Bankier AA, MacMahon H, McLoud TC, Müller NL, Remy J. Fleischner Society: glossary of terms for thoracic imaging. Radiology 2008; 246(3):697-722. doi:10.1148/radiol.2462070712
- Malainou C. Herold S. Influenza. Internist (Berl) 2019; 60(11):1127-1135. doi:10.1007/s00108-019-00670-6
- De Wit E, Van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol 2016;14(8):523-34. doi: 10.1038/nrmicro.2016.81
- Hui DSC. Severe acute respiratory syndrome: historical, epidemiologic, and clinical features. Infect Dis Clin North Am 2019; 33(4):869-889. doi:10.1016/j.idc.2019.07.001
- Chan JF, Lau SK, To KK, Cheng VC, Woo PC, Yuen KY. Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like Disease. Clin Microbiol Rev 2015; 28(2): 465-522. doi: 10.1128/CMR.00102-14.
- Chan JF, Li KS, To KK, Cheng VC, Chen H, Yuen KY. Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic? J Infect 2012; 65(6):477-489. doi:10.1016/j.jinf.2012.10.002.
- Peiris JS, Chu CM, Cheng VC, et al. . Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet 2003;361(9371):1767-1772. doi: 10.1016/s0140-6736(03)13412-5.
- Hui DSC. Severe acute respiratory syndrome: historical, epidemiologic, and clinical features. Infect Dis Clin North Am 2019; 33(4):869-889. doi:10.1016/j.idc.2019.07.001
- World Health Organization . Guidance on regulations for the transport of infectious substances 2019–2020. 2019. At .
- Poon LL, Chan KH, Wong OK, et al. . Early diagnosis of SARS coronavirus infection by real time RT-PCR. J Clin Virol 2003; 28(3):233-238. doi: 10.1016/j.jcv.2003.08.004.
- Ng EK, Hui DS, Chan KC, et al. . Quantitative analysis and prognostic implication of SARS coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome. Clin Chem 2003;49(12):1976-1980. doi:10.1373/clinchem.2003.024125
- Ng EK, Ng PC, Hon KL, et al. . Serial analysis of the plasma concentration of SARS coronavirus RNA in pediatric patients with severe acute respiratory syndrome. Clin Chem 2003; 49(12):2085-2088. doi:10.1373/clinchem.2003.024588
- Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J. Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing. Radiology 2020:200343. doi: 10.1148/radiol.2020200343
- Huang P, Liu T, Huang L, et al. . Use of chest CT in combination with negative RT-PCR assay for the 2019 novel coronavirus but high clinical suspicion. Radiology 2020:200330. doi: 10.1148/radiol.2020200330
- Fang Y, Zhang H, Xie J, Lin M, Ying L, Pang P, Ji W. Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR. Radiology 2020:200432. doi: 10.1148/radiol.2020200432. [Epub ahead of print]
Source: PubMed