Phaco-UCP; combined phacoemulsification and ultrasound ciliary plasty versus phacoemulsification alone for management of coexisting cataract and open angle glaucoma: a randomized clinical trial

Magda A Torky, Yousef A Alzafiri, Ameera G Abdelhameed, Eman A Awad, Magda A Torky, Yousef A Alzafiri, Ameera G Abdelhameed, Eman A Awad

Abstract

Background: Various surgical techniques have been described, to be combined with cataract surgery in glaucoma patients, aiming for an additional reduction of intraocular pressure (IOP), hence minimizing the burden of anti-glaucoma medication (AGM). Ultrasound ciliary plasty (UCP) is a recent microinvasive glaucoma surgery (MIGS) recommended for primary and refractory glaucoma. This study was conducted to evaluate the safety and efficacy of a new technique; combined phacoemulsification and ultrasound ciliary plasty (Phaco-UCP) as a primary surgical treatment for coexisting cataract and open angle glaucoma.

Methods: A randomized clinical trial, including 61 eyes of 61 patients with visually significant cataract and open angle glaucoma, randomized to either Phaco-UCP (study group; 31 eyes) or phacoemulsification alone (Phaco-alone) (control group; 30 eyes). Primary outcomes included reduction in IOP and/or the number of AGM. Secondary outcomes included visual acuity improvement and complications. Qualified Success was defined as an IOP reduction ≥ 20% from baseline value, with an IOP 6-21 mmHg, with no additional AGM or glaucoma surgery. Failure was defined as either < 20% IOP reduction, despite AGM use, the need of glaucoma surgeries or serious complications.

Results: At 18 months postoperatively, Phaco-UCP group had a median IOP reduction of 7 mmHg (Q1, Q3 = 3, 10) compared to 2 mmHg (Q1, Q3 = 2, 3) in Phaco-alone group (P < 0.001). Phaco-UCP group had significantly higher success rate at all time points reaching 67.7% at the last follow-up versus 16.7% only in Phaco-alone group (P< 0.001). The median number of AGM significantly decreased from [3 (Q1, Q3 = 2, 4), 3 (Q1, Q3 = 2,3)] respectively, (P =0.3)] at baseline to [1 (Q1,Q3 = 1, 2), 2 (Q1,Q3 = 2, 2)] respectively, (P < 0.001)] at 18 months postoperatively. No serious intraoperative or postoperative complications were encountered in either group.

Conclusion: Phaco-UCP is a simple, safe and effective procedure for management of coexisting cataract and open angle glaucoma.

Trial registration: ClinicalTrials.gov identifier, NCT04430647 ; retrospectively registered. June 12, 2020.

Keywords: OAG; Phaco-UCP; Phacoemulsification; Ultrasound ciliary plasty.

Conflict of interest statement

The authors have no proprietary or commercial interest in the medical devices that are involved in this manuscript.

Figures

Fig. 1
Fig. 1
CONSORT Flowchart of study participants
Fig. 2
Fig. 2
Changes in the median IOP (mmHg) in both groups at different time points
Fig. 3
Fig. 3
Postoperative median IOP (mmHg) in both groups at the 18th month follow-up visit

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