Developments in the clinical understanding of osteoarthritis

David T Felson, David T Felson

Abstract

With the recognition that osteoarthritis is a disease of the whole joint, attention has focused increasingly on features in the joint environment which cause ongoing joint damage and are likely sources of pain. This article reviews current ways of assessing osteoarthritis progression and what factors potentiate it, structural abnormalities that probably produce pain, new understandings of the genetics of osteoarthritis, and evaluations of new and old treatments.

Figures

Figure 1
Figure 1
Gadolinium-enhanced magnetic resonance image (sagittal view) of a knee with multiple structural features typical of osteoarthritis. There are bone marrow lesions, cysts, and synovial thickening.

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