Role of Platelet rich fibrin in wound healing: A critical review

Balaram Naik, P Karunakar, M Jayadev, V Rahul Marshal, Balaram Naik, P Karunakar, M Jayadev, V Rahul Marshal

Abstract

Aim: The aim is to review and discuss the strategies available for use of platelet rich fibrin as healing aid in dentistry.

Background: Platelet rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors, and cells are trapped and may be released after a certain time and that can serve as a resorbable membrane. Choukroun and his associates were amongst the pioneers for using PRF protocol in oral and maxillofacial surgery to improve bone healing in implant dentistry. Autologous PRF is considered to be a healing biomaterial, and presently, studies have shown its application in various disciplines of dentistry.

Materials and methods: By using specific keywords, electronic search of scientific papers was carried out on the entire PubMed database with custom range of 5 years. The electronic search yielded 302 papers; based on inclusion and exclusion criteria which were specifically predetermined, 72 papers were identified as suitable to the inclusion criteria and the remaining 230 papers were excluded. After adding three more selected papers through hand search, full text of all the articles retrieved and review was done. By pooling the extracted data from selected papers, the reviewed data was synthesized.

Conclusion: Recently by showing good promising results with use of the PRF, it has proved to have a good prospect for its use as healing aid in various aspects of the dentistry.

Keywords: Growth factors; platelet rich fibrin; platelet rich plasma; wound healing.

Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Search flowchart on PubMed database
Figure 2
Figure 2
Flowchart of total scrutinized articles
Figure 3
Figure 3
Collection of blood, blood in vacutainer tube after centrifugation, and centrifuge machine
Figure 4
Figure 4
Blood in the vacutainer tubes after centrifugation at 3,000 rpm for 10 min divided into three fractions; lower fraction of red blood cells, middle fraction containing fibrin clot, and upper acellular plasma fraction
Figure 5
Figure 5
Isolated platelet rich fibrin

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