Smell and taste disorders

Thomas Hummel, Basile N Landis, Karl-Bernd Hüttenbrink, Thomas Hummel, Basile N Landis, Karl-Bernd Hüttenbrink

Abstract

Smell and taste disorders can markedly affect the quality of life. In recent years we have become much better in the assessment of the ability to smell and taste. In addition, information is now available to say something about the prognosis of individual patients. With regard to therapy there also seems to be low but steady progress. Of special importance for the treatment is the ability of the olfactory epithelium to regenerate.

Keywords: anosmia; dysgeusia; flavor; gustation; olfaction.

Figures

Table 1. Features of post-trauma, post-viral/infection and…
Table 1. Features of post-trauma, post-viral/infection and sinunasal smell disorders
Table 2. Relative degree of olfactory dysfunction…
Table 2. Relative degree of olfactory dysfunction associated with neurodegenerative diseases.
+++: high degree of smell loss; 0/(+): no smell loss or slight smell loss. The majority of the findings are based on studies on small groups of patients.
Table 3. Medicines which may cause smell…
Table 3. Medicines which may cause smell disorders
Table 4. Medicines which may cause taste…
Table 4. Medicines which may cause taste disorders

References

    1. Stevenson RJ. An initial evaluation of the functions of human olfaction. Chem Senses. 2010;35:3–20. doi: 10.1093/chemse/bjp083. Available from: .
    1. Miwa T, Furukawa M, Tsukatani T, Costanzo RM, DiNardo LJ, Reiter ER. Impact of olfactory impairment on quality of life and disability. Arch Otolaryngol Head Neck Surg. 2001;127:497–503.
    1. Temmel AF, Quint C, Schickinger-Fischer B, Klimek L, Stoller E, Hummel T. Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg. 2002;128:635–641.
    1. Santos DV, Reiter ER, DiNardo LJ, Costanzo RM. Hazardous events associated with impaired olfactory function. Arch Otolaryngol Head Neck Surg. 2004;130:317–319. doi: 10.1001/archotol.130.3.317. Available from: .
    1. Frasnelli J, Hummel T. Olfactory dysfunction and daily life. Eur Arch Otolaryngol. 2005;262:231–238. doi: 10.1007/s00405-004-0796-y. Available from: .
    1. Murphy C, Schubert CR, Cruickshanks KJ, Klein BE, Klein R, Nondahl DM. Prevalence of olfactory impairment in older adults. Jama. 2002;288:2307–2312. doi: 10.1001/jama.288.18.2307. Available from: .
    1. Brämerson A, Johansson L, Ek L, Nordin S, Bende M. Prevalence of olfactory dysfunction: The Skövde population-based study. Laryngoscope. 2004;114:733–737. doi: 10.1097/00005537-200404000-00026. Available from: .
    1. Landis BN, Konnerth CG, Hummel T. A study on the frequency of olfactory dysfunction. Laryngoscope. 2004;114:1764–1769. doi: 10.1097/00005537-200410000-00017. Available from: .
    1. Vennemann MM, Hummel T, Berger K. The association between smoking and smell and taste impairment in the general population. J Neurol. 2008;255:1121–1126. doi: 10.1007/s00415-008-0807-9. Available from: .
    1. Doty RL, Shaman P, Applebaum SL, Giberson R, Sikorski L, Rosenberg L. Smell identification ability: changes with age. Science. 1984;226:1441–1443. doi: 10.1126/science.6505700. Available from: .
    1. Mackay-Sim A, Johnston AN, Owen C, Burne TH. Olfactory ability in the healthy population: Reassessing presbyosmia. Chem Senses. 2006;31:763–771. doi: 10.1093/chemse/bjl019. Available from: .
    1. Wilson RS, Yu L, Bennett DA. Odor identification and mortality in old age. Chem Senses. 2011 Jan;36(1):63–67. doi: 10.1093/chemse/bjq098. Available from: .
    1. Kobal G. Process for measuring sensory qualities and apparatus therefor. United States patent US 4,681,121. Jul 21, 1987.
    1. Witt M, Hummel T. Vomeronasal versus olfactory epithelium: Is there a cellular basis for human vomeronasal perception? Int Rev Cytol. 2006;248C:209–259. doi: 10.1016/S0074-7696(06)48004-9. Available from: .
    1. Frasnelli J, Lundström JN, Boyle JA, Katsarkas A, Jones-Gotman M. The vomeronasal organ is not involved in the perception of endogenous odors. Hum Brain Mapp. 2011 Mar;32(3):450–460. doi: 10.1002/hbm.21035. Available from: .
    1. Schwanzel-Fukuda M, Pfaff DW. Structure and function of the nervus terminalis. In: Doty RL, editor. Handbook of olfaction and gustation. New York: Marcel Dekker; 1995.
    1. Delank KW, Stoll W. Die Riechfunktion vor und nach endonasaler Operation der chronisch-polypösen Sinusitis. HNO. 1994;42:619–623.
    1. Zhao K, Scherer PW, Hajiloo SA, Dalton P. Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfaction. Chem Senses. 2004;29:365–379. doi: 10.1093/chemse/bjh033. Available from: .
    1. Damm M, Vent J, Schmidt M, Theissen P, Eckel HE, Lotsch J, Hummel T. Intranasal volume and olfactory function. Chem Senses. 2002;27:831–839. doi: 10.1093/chemse/27.9.831. Available from: .
    1. Pfaar O, Hüttenbrink KB, Hummel T. Assessment of olfactory function after septoplasty: A longitudinal study. Rhinology. 2004;42:195–199.
    1. Landis BN, Frasnelli J, Reden J, Lacroix JS, Hummel T. Differences between orthonasal and retronasal olfactory functions in patients with loss of the sense of smell. Arch Otolaryngol Head Neck Surg. 2005;131:977–981. doi: 10.1001/archotol.131.11.977. Available from: .
    1. Konstantinidis I, Triaridis S, Triaridis A, Petropoulos I, Karagiannidis K, Kontzoglou G. How do children with adenoid hypertrophy smell and taste? Clinical assessment of olfactory function pre- and post-adenoidectomy. Int J Pediatr Otorhinolaryngol. 2005;69:1343–1349. doi: 10.1016/j.ijporl.2005.03.022. Available from: .
    1. Moulton DG. Dynamics of cell populations in the olfactory epithelium. Ann NY Acad Sci. 1974;237:52–61. doi: 10.1111/j.1749-6632.1974.tb49843.x. Available from: .
    1. Gradziadei PPC, Monti-Graziadei GA. Continuous nerve cell renewal in the olfactory system. In: Jacobson M, editor. Handbook of sensory physiology. Vol 9. New York: Springer; 1978.
    1. Breipohl W, Mackay-Sim A, Grandt D, Rehn B, Darrelmann C. Neurogenesis in the vertebrate main olfactory epithelium. In: Breipohl W, editor. Ontogeny of olfaction. Berlin: Springer; 1986. Available from: .
    1. Nakamura H, Fujiwara M, Kawasaki M, Nonomura N, Takahashi S. Age-related changes in dividing cells of the olfactory epithelium of the maturing guinea pig. Eur Arch Otorhinolaryngol. 1998;255:289–292. doi: 10.1007/s004050050061. Available from: .
    1. Paik SI, Lehman MN, Seiden AM, Duncan HJ, Smith DV. Human olfactory biopsy: the influence of age and receptor distribution. Arch Otolaryngol. 1992;118:731–738. doi: 10.1001/archotol.1992.01880070061012. Available from: .
    1. Reden J, Mueller A, Mueller C, Konstantinidis I, Frasnelli J, Landis BN, Hummel T. Recovery of olfactory function following closed head injury or infections of the upper respiratory tract. Arch Otolaryngol Head Neck Surg. 2006;132:265–269. doi: 10.1001/archotol.132.3.265. Available from: .
    1. Ohloff G. Riechstoffe und Geruchssinn. Berlin: Springer Verlag; 1990.
    1. Bignetti E, Cavaggioni A, Pelosi P, Presaud KC, Sorbi RT, Tirindelli R. Purification and characterization of an odorant-binding protein from cow nasal tissue. Eur J Biochem. 1985;149:227–231. doi: 10.1111/j.1432-1033.1985.tb08916.x. Available from: .
    1. Briand L, Eloit C, Nespoulous C, Bezirard V, Huet JC, Henry C, Blon F, Trotier D, Pernollet JC. Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. Biochemistry. 2002;41:7241–7252. doi: 10.1021/bi015916c. Available from: .
    1. Federico G, Maremmani C, Cinquanta L, Baroncelli GI, Fattori B, Saggese G. Mucus of the human olfactory epithelium contains the insulin-like growth factor-I system which is altered in some neurodegenerative diseases. Brain Res. 1999;835:306–314. doi: 10.1016/S0006-8993(99)01614-5. Available from: .
    1. Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell. 1991;65:175–187. doi: 10.1016/0092-8674(91)90418-X. Available from: .
    1. Firestein S. How the olfactory system makes sense of scents. Nature. 2001;413:211–218. doi: 10.1038/35093026. Available from: .
    1. Larsson M, Backman L. Modality memory across the adult life span: evidence for selective age-related olfactory deficits. Exp Aging Res. 1998;24:63–82. doi: 10.1080/036107398244364. Available from: .
    1. Gottfried JA. Smell: central nervous processing. Adv Otorhinolaryngol. 2006;63:44–69. doi: 10.1159/000093750. Available from: .
    1. Shepherd GM. Perspectives on olfactory processing, conscious perception, and orbitofrontal cortex. Ann N Y Acad Sci. 2007;1121:87–101. doi: 10.1196/annals.1401.032. Available from: .
    1. Doty RL, Cameron EL. Sex differences and reproductive hormone influences on human odor perception. Physiol Behav. 2009;97:213–228. doi: 10.1016/j.physbeh.2009.02.032. Available from: .
    1. Huttenbrink KB. Riech- und Schmeckstörungen: Bewährtes und Neues zu Diagnostik und Therapie. Laryngorhinootologie. 1997;76:506–514. doi: 10.1055/s-2007-997469. Available from: .
    1. Almkvist O, Berglund B, Nordin S. Odor detectability in successfully aged elderly and young adults. Reports from the Dept of Psychology, Stockholm University. 1992;744:1–12.
    1. Landis BN, Hummel T, Hugentobler M, Giger R, Lacroix JS. Ratings of overall olfactory function. Chem Senses. 2003;28:691–694. doi: 10.1093/chemse/bjg061. Available from: .
    1. Shu CH, Hummel T, Lee PL, Chiu CH, Lin SH, Yuan BC. The proportion of self-rated olfactory dysfunction does not change across the life span. Am J Rhinol Allergy. 2009;23:413–416. doi: 10.2500/ajra.2009.23.3343. Available from: .
    1. Amoore JE. Specific anosmias. In: Getchell TV, et al., editors. Smell and taste in health and disease. New York: Raven Press; 1991.
    1. Menashe I, Man O, Lancet D, Gilad Y. Different noses for different people. Nat Genet. 2003;34:143–144. doi: 10.1038/ng1160. Available from: .
    1. Henkin RI. Hyperosmia and depression following exposure to toxic vapors. JAMA. 1990;264:2803. doi: 10.1001/jama.264.21.2803. Available from: .
    1. Blau JN, Solomon F. Smell and other sensory disturbances in migraine. J Neurol. 1985;232:275–276. doi: 10.1007/BF00313864. Available from: .
    1. Leopold D. Distortion of olfactory perception: diagnosis and treatment. Chem Senses. 2002;27:611–615. doi: 10.1093/chemse/27.7.611. Available from: .
    1. Hummel T, Welge-Luessen A. Erfassung des Riech- und Schmeckvermögens. In: Hummel T, Welge-Luessen A, editors. Riech- und Schmeckstörungen. Stuttgart: Georg Thieme Verlag KG; 2009.
    1. Landis BN, Frasnelli J, Croy I, Hummel T. Evaluating the clinical usefulness of structured questions in parosmia assessment. Laryngoscope. 2010;120:1707–1713. doi: 10.1002/lary.20955. Available from: .
    1. Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF, Kimmelman CP, Brightman VJ, Snow JBj. Smell and taste disorders: a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otorhinolaryngol Head Neck Surg. 1991;117:519–528. doi: 10.1001/archotol.1991.01870170065015. Available from: .
    1. Gudziol H, Rahneberg K, Burkert S. Anosmiker schmecken schlechter als Gesunde. [Anosmics are more poorly able to taste than normal persons]. Laryngorhinootologie. 2007 Sep;86(9):640–643. doi: 10.1055/s-2007-966228. (Ger). Available from: .
    1. Landis BN, Scheibe M, Weber C, Berger R, Brämerson A, Bende M, Nordin S, Hummel T. Chemosensory interaction: acquired olfactory impairment is associated with decreased taste function. J Neurol. 2010;257:1303–1308. doi: 10.1007/s00415-010-5513-8. Available from: .
    1. Stinton N, Atif MA, Barkat N, Doty RL. Influence of smell loss on taste function. Behav Neurosci. 2010;123:256–264. doi: 10.1037/a0018766. Available from: .
    1. Delank KW, Fechner G. Zur Pathophysiologie der posttraumatischen Riechstörungen. Laryngol Rhinol Otol. 1996;75:154–159. doi: 10.1055/s-2007-997554. Available from: .
    1. Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T. Retronasal and orthonasal olfactory function in relation to olfactory bulb volume in patients with posttraumatic loss of smell. Laryngoscope. 2006;116:901–905. doi: 10.1097/01.mlg.0000217533.60311.e7. Available from: .
    1. Yamagishi M, Fujiwara M, Nakamura H. Olfactory mucosal findings and clinical course in patients with olfactory disorders following upper respiratory viral infection. Rhinology. 1994;32:113–118.
    1. Konstantinidis I, Haehner A, Frasnelli J, Reden J, Quante G, Damm M, Hummel T. Post-infectious olfactory dysfunction exhibits a seasonal pattern. Rhinology. 2006;44:135–139.
    1. Suzuki M, Saito K, Min WP, Vladau C, Toida K, Itoh H, Murakami S. Identification of viruses in patients with postviral olfactory dysfunction. Laryngoscope. 2007;117:272–277. doi: 10.1097/01.mlg.0000249922.37381.1e. Available from: .
    1. Delank KW, Stoll W. Pre- and postoperative olfactory function in patients with chronic sinusitis and nasal polyposis. HNO. 1994;42:619–623.
    1. Seiden AM. Olfactory loss secondary to nasal and sinus pathology. In: Seiden AM, editor. Taste and smell disorders. New York: Thieme; 1997.
    1. Kesslak JP, Cotman CW, Chui HC, van den Noort S, Fang H, Pfeffer R, Lynch G. Olfactory tests as possible probes for detecting and monitoring Alzheimer's disease. Neurobiol Aging. 1988;9:399–403. doi: 10.1016/S0197-4580(88)80087-3. Available from: .
    1. Ponsen MM, Stoffers D, Booij J, van Eck-Smit BL, Wolters EC, Berendse HW. Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann Neurol. 2004;56:173–181. doi: 10.1002/ana.20160. Available from: .
    1. Haehner A, Boesveldt S, Berendse HW, Mackay-Sim A, Fleischmann J, Silburn PA, Johnston AN, Mellick GD, Herting B, Reichmann H, Hummel T. Prevalence of smell loss in Parkinson's disease – a multicenter study. Parkinsonism Relat Disord. 2009;15:490–494. doi: 10.1016/j.parkreldis.2008.12.005. Available from: .
    1. Ansari KA, Johnson A. Olfactory function in patients with Parkinson's disease. J Chron Dis. 1975;28:493–497. doi: 10.1016/0021-9681(75)90058-2. Available from: .
    1. Doty RL, Deems D, Steller S. Olfactory dysfunction in Parkinson's disease: A general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology. 1988;38:1237–1244.
    1. Haehner A, Hummel T, Hummel C, Sommer U, Junghanns S, Reichmann H. Olfactory loss may be a first sign of idiopathic Parkinson’s disease. Mov Disorders. 2007;22:839–842. doi: 10.1002/mds.21413. Available from: .
    1. Hummel T, Kobal G, Gudziol H, Mackay-Sim A. Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol. 2007;264:237–243. doi: 10.1007/s00405-006-0173-0. Available from: .
    1. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging. 2003;24:197–211. doi: 10.1016/S0197-4580(02)00065-9. Available from: .
    1. Ross GW, Petrovitch H, Abbott R, Tanner CM, Popper J, Masaki K, Launer L, White LR. Association of olfactory dysfunction with risk for future Parkinson’s disease. Ann Neurol. 2008;63:167–173.
    1. Westermann B, Wattendorf E, Schwerdtfeger U, Husner A, Fuhr P, Gratzl O, Hummel T, Bilecen D, Welge-Lüssen A. Functional imaging of the cerebral olfactory system in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 2008;79:19–24. doi: 10.1136/jnnp.2006.113860. Available from: .
    1. Wenning GK, Shephard B, Hawkes C, Petruckevitch A, Lees A, Quinn N. Olfactory function in atypical parkinsonian syndromes. Acta Neurol Scand. 1995;91:247–250. doi: 10.1111/j.1600-0404.1995.tb06998.x. Available from: .
    1. Welge-Lüssen A, Wattendorf E, Schwerdtfeger U, Fuhr P, Bilecen D, Hummel T, Westermann B. Olfactory-induced brain activity in Parkinson's disease relates to the expression of event-related potentials: a functional magnetic resonance imaging study. Neuroscience. 2009;162:537–543. doi: 10.1016/j.neuroscience.2009.04.050. Available from: .
    1. Nordin S, Paulsen JS, Murphy C. Sensory- and memory-mediated olfactory dysfunction in Huntington's disease. J Int Neuropsychol Soc. 1995;1:281–290. doi: 10.1017/S1355617700000278. Available from: .
    1. Mesholam RI, Moberg PJ, Mahr RN, Doty RL. Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol. 1998;55:84–90. doi: 10.1001/archneur.55.1.84. Available from: .
    1. Hawkes C. Olfaction in neurodegenerative disorder. Adv Otorhinolaryngol. 2006;63:133–151. doi: 10.1159/000093759. Available from: .
    1. Wilson RS, Arnold SE, Schneider JA, Boyle PA, Buchman AS, Bennett DA. Olfactory impairment in presymptomatic Alzheimer's disease. Ann N Y Acad Sci. 2009;1170:730–735. doi: 10.1111/j.1749-6632.2009.04013.x. Available from: .
    1. Heilmann S, Hüttenbrink KB, Hummel T. Local and systemic administration of corticosteroids in the treatment of olfactory loss. Am J Rhinol. 2004;18:29–33.
    1. Biacabe B, Faulcon P, Amanou L, Bonfils P. Olfactory cleft disease: an analysis of 13 cases. Otolaryngol Head Neck Surg. 2004;130:202–208. doi: 10.1016/j.otohns.2003.09.002. Available from: .
    1. Damm M, Eckel HE, Streppel M, Jungehülsing M, Stennert E. Abhängigkeit des uni- und bilateralen Riechvermögens von der nasalen Strömung bei Patienten mit chronischer Rhinosinusitis. HNO. 2000;48:436–443. doi: 10.1007/s001060050594. Available from: .
    1. Gudziol H, Forster G. Zur Durchführung präoperativer Riechtests aus medicolegaler Sicht. Laryngorhinootologie. 2002;81:586–590. doi: 10.1055/s-2002-33360. Available from: .
    1. Hummel T, Sekinger B, Wolf S, Pauli E, Kobal G. "Sniffin' Sticks": Olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses. 1997;22:39–52. doi: 10.1093/chemse/22.1.39. Available from: .
    1. Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM, Seeber H, Pauli E, Hummel T. Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur Arch Otorhinolaryngol. 2000;257:205–211. doi: 10.1007/s004050050223. Available from: .
    1. Hummel T, Konnerth CG, Rosenheim K, Kobal G. Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss. Ann Otol Rhinol Laryngol. 2001;110:976–981.
    1. Hummel T, Pfetzing U, Lötsch J. A short olfactory test based on the identification of three odors. J Neurol. 2010;257:1316–1321. doi: 10.1007/s00415-010-5516-5. Available from: .
    1. Mueller C, Renner B. A new procedure for the short screening of olfactory function using five items from the "Sniffin' Sticks" identification test kit. Am J Rhinol. 2006;20:113–116.
    1. Royet JP, Hudry J, Zald DH, Godinot D, Gregoire MC, Lavenne F, Costes N, Holley A. Functional neuroanatomy of different olfactory judgments. Neuroimage. 2001;13:506–519. doi: 10.1006/nimg.2000.0704. Available from: .
    1. Lötsch J, Reichmann H, Hummel T. Different odor tests contribute differently to the diagnostics of olfactory loss. Chem Senses. 2008;33:17–21.
    1. Hedner M, Larsson M, Arnold N, Zucco GM, Hummel T. Cognitive factors in odor detection, odor discrimination, and odor identification tasks. J Clin Exp Neuropsychol. 2010;30:1–6.
    1. Doty RL, Smith R, McKeown DA, Raj J. Tests of human olfactory function: principle component analysis suggests that most measure a common source of variance. Percept Psychophys. 1994;56:701–707. doi: 10.3758/BF03208363. Available from: .
    1. Doty RL, McKeown DA, Lee WW, Shaman P. A study of the test-retest reliability of ten olfactory tests. Chem Senses. 1995;20:645–656. doi: 10.1093/chemse/20.6.645. Available from: .
    1. Hummel T, Lange K, Lötsch J. Vergleich neuartiger Riechschwellenbestimmungen mit der „klassischen“ Butanol-Schwelle. Available from: .
    1. Haehner A, Mayer AM, Landis BN, Pournaras I, Lill K, Gudziol V, Hummel T. High test-retest reliability of the extended version of the "Sniffin' Sticks" test. Chem Senses. 2009;34:705–711. doi: 10.1093/chemse/bjp057. Available from: .
    1. Doty RL, Shaman P, Kimmelman CP, Dann MS. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope. 1984;94:176–178. doi: 10.1288/00005537-198402000-00004. Available from: .
    1. Mueller CA, Grassinger E, Naka A, Temmel AF, Hummel T, Kobal G. A Self-administered Odor Identification Test Procedure Using the "Sniffin' Sticks". Chem Senses. 2006;31:595–598. doi: 10.1093/chemse/bjj064. Available from: .
    1. Frank RA, Gesteland RC, Bailie J, Rybalsky K, Seiden A, Dulay MF. Characterization of the sniff magnitude test. Arch Otolaryngol Head Neck Surg. 2006;132:532–536. doi: 10.1001/archotol.132.5.532. Available from: .
    1. Güttich H. Gustatorische Riechprüfung mit Riechstoffen und Mischreizschmeckstoffen. Arch Ohren Nasen Kehlk Heilk. 1961;178:327–330.
    1. Güttich H. Intravenös verabreichte Riechstoffe: Gustatorisches Riechen. HNO. 1965;13:42–45.
    1. Hummel T, Rosenheim K, Knecht M, Heilmann S, Murbe D, Hüttenbrink KB. Der gustatorische Riechtest in der Technik nach Güttich: Eine Überprüfung der klinischen Brauchbarkeit. Laryngorhinootologie. 1999;78:627–631. doi: 10.1055/s-1999-12978. Available from: .
    1. Heilmann S, Strehle G, Rosenheim K, Damm M, Hummel T. Clinical assessment of retronasal olfactory function. Arch Otorhinolaryngol Head Neck Surg. 2002;128:414–418.
    1. Heilmann S, Hummel T. A new method for comparing orthonasal and retronasal olfaction. Behav Neurosci. 2004;118:412–419. doi: 10.1037/0735-7044.118.2.412. Available from: .
    1. Leon EA, Catalanotto FA, Werning JW. Retronasal and orthonasal olfactory ability after laryngectomy. Arch Otolaryngol Head Neck Surg. 2007;133:32–36. doi: 10.1001/archotol.133.1.32. Available from: .
    1. Hummel T, Klimek L, Welge-Lussen A, Wolfensberger G, Gudziol H, Renner B, Kobal G. Chemosensorisch evozierte Potentiale zur klinischen Diagnostik von Riechstörungen. HNO. 2000;48:481–485. doi: 10.1007/s001060050602. Available from: .
    1. Kobal G. Elektrophysiologische Untersuchungen des menschlichen Geruchssinns. Stuttgart: Thieme Verlag; 1981.
    1. Hummel T, Klimek L, Welge-Lüssen A, Wolfensberger G, Gudziol H, Renner B, Kobal G. Standards für die Ableitung chemosensorisch evozierter Potentiale zur klinischen Diagnostik von Riechstörungen. HNO. 2000;48:481–485. doi: 10.1007/s001060050602. Available from: .
    1. Lötsch J, Hummel T. The clinical significance of electrophysiological measures of olfactory function. Behav Brain Res. 2006;170:78–83. doi: 10.1016/j.bbr.2006.02.013. Available from: .
    1. Rombaux P, Bertrand B, Keller T, Mouraux A. Clinical significance of olfactory event-related potentials related to orthonasal and retronasal olfactory testing. Laryngoscope. 2007;117:1096–1101. doi: 10.1097/MLG.0b013e31804d1d0d. Available from: .
    1. Lascano AM, Hummel T, Lacroix JS, Landis BN, Michel CM. Spatio-temporal dynamics of olfactory processing in the human brain: an event-related source imaging study. Neuroscience. 2010;167:700–708. doi: 10.1016/j.neuroscience.2010.02.013. Available from: .
    1. Knecht M, Hummel T. Recording of the human electro-olfactogram. Physiol Behav. 2004;83:13–19.
    1. Lapid H, Schuster B, Schneidman E, Roth Y, Harel D, Sobel N, Hummel T. Odorant identity and concentration effects in electro-olfactograms recorded at the human olfactory epithelium. J Neurophysiol. 2009;102:2121–2130. doi: 10.1152/jn.91321.2008. Available from: .
    1. Yousem DM, Geckle RJ, Bilker WB, Doty RL. Olfactory bulb and tract and temporal lobe volumes. Normative data across decades. Ann N Y Acad Sci. 1998;855:546–555. doi: 10.1111/j.1749-6632.1998.tb10624.x. Available from: .
    1. Yousem DM, Geckle RJ, Bilker WB, Kroger H, Doty RL. Posttraumatic smell loss: relationship of psychophysical tests and volumes of the olfactory bulbs and tracts and the temporal lobes. Acad Radiol. 1999;6:264–272. doi: 10.1016/S1076-6332(99)80449-8. Available from: .
    1. Abolmaali N, Hummel T, Damm M. Moderne bildgebende Diagnostik bei Riechstörungen. Laryngorhinootologie. 2009;88:10–16. doi: 10.1055/s-2008-1077630. Available from: .
    1. Rombaux P, Duprez T, Hummel T. Olfactory bulb volume in the clinical assessment of olfactory dysfunction. Rhinology. 2009;47:3–9.
    1. Haehner A, Rodewald A, Gerber JC, Hummel T. Changes of the volume of the human olfactory bulb with olfactory function. Arch ORL. 2008;134:621–624.
    1. Gudziol V, Buschhuter D, Abolmaali N, Gerber J, Rombaux P, Hummel T. Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis – a longitudinal study. Brain. 2009;132:3096–3101. doi: 10.1093/brain/awp243. Available from: .
    1. Bitter T, Brüderle J, Gudziol H, Burmeister HP, Gaser C, Guntinas-Lichius O. Gray and white matter reduction in hyposmic subjects – A voxel-based morphometry study. Brain Res. 2010;1347:42–47. doi: 10.1016/j.brainres.2010.06.003. Available from: .
    1. Bitter T, Gudziol H, Burmeister HP, Mentzel HJ, Guntinas-Lichius O, Gaser C. Anosmia leads to a loss of gray matter in cortical brain areas. Chem Senses. 2010;35:407–415. doi: 10.1093/chemse/bjq028. Available from: .
    1. Frasnelli J, Lundstrom JN, Boyle JA, Djordjevic J, Zatorre RJ, Jones-Gotman M. Neuroanatomical correlates of olfactory performance. Exp Brain Res. 2010;201:1–11. doi: 10.1007/s00221-009-1999-7. Available from: .
    1. Gottfried JA, Winston JS, Dolan RJ. Dissociable codes of odor quality and odorant structure in human piriform cortex. Neuron. 2006;49:467–479. doi: 10.1016/j.neuron.2006.01.007. Available from: .
    1. Iannilli E, Gerber J, Frasnelli J, Hummel T. Intranasal trigeminal function in subjects with and without an intact sense of smell. Brain Res. 2007;1139:235–244. doi: 10.1016/j.brainres.2006.12.082. Available from: .
    1. Feron F, Perry C, Cochrane J, Licina P, Nowitzke A, Urquhart S, Geraghty T, Mackay-Sim A. Autologous olfactory ensheathing cell transplantation in human spinal cord injury. Brain. 2005;128:2951–2960. doi: 10.1093/brain/awh657. Available from: .
    1. Haxel BR, Murrell WG, Mackay-Sim A. Untersuchungen der Riechschleimhaut von anosmischen Patienten nach Schädel-Hirn-Trauma. HNO. 2005;53:688–689.
    1. Witt M, Bormann K, Gudziol V, Pehlke K, Barth K, Minovi A, Hahner A, Reichmann H, Hummel T. Biopsies of olfactory epithelium in patients with Parkinson's disease. Mov Disord. 2009;24:906–914. doi: 10.1002/mds.22464. Available from: .
    1. Trotier D, Bensimon JL, Herman P, Tran Ba Huy P, Døving KB, Eloit C. Inflammatory obstruction of the olfactory clefts and olfactory loss in humans: a new syndrome? Chem Senses. 2007;32:285–292. doi: 10.1093/chemse/bjl057. Available from: .
    1. Mueller CA, Hummel T. Recovery of olfactory function after nine years: An unusual case report of posttraumatic anosmia. J Med Case Reports. 2009;3:9283. doi: 10.4076/1752-1947-3-9283. Available from: .
    1. Minovi A, Hummel T, Ural A, Draf W, Bockmühl U. Predictors of the outcome of nasal surgery in terms of olfactory function. Eur Arch Otorhinolaryngol. 2007;265:57–62. doi: 10.1007/s00405-007-0409-7. Available from: .
    1. Pade J, Hummel T. Olfactory function following nasal surgery. Laryngoscope. 2008;118:1260–1264.
    1. Jafek BW, Moran DT, Eller PM, Rowley JC, 3rd, Jafek TB. Steroid-dependent anosmia. Arch Otolaryngol Head Neck Surg. 1987 May;113(5):547–549. doi: 10.1001/archotol.1987.01860050093023. Available from: .
    1. Heilmann T, Just T, Goktas O, Hauswald B, Hüttenbrink KB, Hummel T. Untersuchung der Wirksamkeit von systemischen bzw. topischen Kortikoiden und Vitamin B bei Riechstörungen. Laryngo-Rhino-Otol. 2004;83:729–734. doi: 10.1055/s-2004-825676. Available from: .
    1. Blomqvist EH, Lundblad L, Bergstedt H, Stjarne P. Placebo-controlled, randomized, double-blind study evaluating the efficacy of fluticasone propionate nasal spray for the treatment of patients with hyposmia/anosmia. Acta Otolaryngol. 2003;123:862–868. doi: 10.1080/00016480310002140. Available from: .
    1. Benninger MS, Hadley JA, Osguthorpe JD, Marple BF, Leopold DA, Derebery MJ, Hannley M. Techniques of intranasal steroid use. Otolaryngol Head Neck Surg. 2004;130:5–24. doi: 10.1016/j.otohns.2003.10.007. Available from: .
    1. Scheibe M, Bethge C, Witt M, Hummel T. Intranasal administration of drugs. Arch Otolaryngol Head Neck Surg. 2008;134(6):643–646. doi: 10.1001/archotol.134.6.643. Available from: .
    1. Panagiotopoulos G, Naxakis S, Papavasiliou A, Filipakis K, Papatheodorou G, Goumas P. Decreasing nasal mucus Ca++ improves hyposmia. Rhinology. 2005;43:130–134.
    1. Hughes LF, McAsey ME, Donathan CL, Smith T, Coney P, Struble RG. Effects of hormone replacement therapy on olfactory sensitivity: cross-sectional and longitudinal studies. Climacteric. 2002;5:140–150.
    1. Henkin RI, Schecter PJ, Friedewald WT, Demets DL, Raff M. A double-blind study of the effects of zinc sulfate on taste and smell dysfunction. Am J Med Sci. 1976;272:285–299. doi: 10.1097/00000441-197611000-00006. Available from: .
    1. Alpers DH. Zinc and deficiencies of taste and smell. Jama. 1994;272:1233–1234. doi: 10.1001/jama.1994.03520160009004. Available from: .
    1. Quint C, Temmel AFP, Hummel T, Ehrenberger K. The quinoxaline derivative caroverine in the treatment of sensorineural smell disorders: a proof of concept study. Acta Otolaryngol. 2002;122:877–881. doi: 10.1080/003655402/000028054. Available from: .
    1. Reden J, Herting B, Lill K, Kern R, Hummel T. Treatment of postinfectious olfactory disorders with minocycline: a double-blind, placebo-controlled study. Laryngoscope. 2011 Mar;121(3):679–682. doi: 10.1002/lary.21401.. Available from:
    1. Lill K, Reden J, Müller A, Zahnert T, Hummel T. Olfactory function in patients with post-infectious and post-traumatic smell disorders before and after treatment with vitamin A: a double-blind, placebo-controlled, randomized clincial trial. Chem Senses. 2006;31:A33.
    1. Garrett-Laster M, Russell RM, Jacques PF. Impairment of taste and olfaction in patients with cirrhosis: the role of vitamin A. Hum Nutr Clin Nutr. 1984;38:203–214.
    1. Duncan H. Postviral olfactory loss. In: Seiden AM, editor. Taste and smell disorders. New York: Thieme; 1997.
    1. Vent J, Wang DW, Damm M. Effects of traditional Chinese acupuncture in post-viral olfactory dysfunction. Otolaryngol Head Neck Surg. 2010;142:505–509. doi: 10.1016/j.otohns.2010.01.012. Available from: .
    1. Silas J, Doty RL. No evidence for specific benefit of acupuncture over vitamin B complex in treating persons with olfactory dysfunction. Otolaryngol Head Neck Surg. 2010;143:603. doi: 10.1016/j.otohns.2010.07.008. Available from: .
    1. Henkin RI, Potolicchio SJ, Jr, Levy LM. Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation. Am J Otolaryngol. 2011 Jan-Feb;32(1):38–46. doi: 10.1016/j.amjoto.2009.10.001. Available from: .
    1. Silas J, Atif MA, Doty RL. Transcranial magnetic stimulation: a treatment for smell and taste dysfunction. Am J Otolaryngol. 2011 Mar-Apr;32(2):177. doi: 10.1016/j.amjoto.2010.07.005. Available from: .
    1. Hummel T, Heilmann S, Hüttenbrink KB. Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract. Laryngoscope. 2002;112:2076–2080. doi: 10.1097/00005537-200211000-00031. Available from: .
    1. Gudziol V, Hummel T. Effects of pentoxifylline on olfactory sensitivity: a postmarketing surveillance study. Arch Otolaryngol Head Neck Surg. 2009;135:291–295. doi: 10.1001/archoto.2008.524. Available from: .
    1. Henkin RI, Velicu I, Schmidt L. An open-label controlled trial of theophylline for treatment of patients with hyposmia. Am J Med Sci. 2009;337:396–406. doi: 10.1097/MAJ.0b013e3181914a97. Available from: .
    1. Hirsch AR, Dougherty DD, Aranda JG, Vanderbilt JG, Weclaw GC. Medications for Olfactory Loss: Pilot Studies. J Neurol Orthop Med Surg. 1996;17:109–114.
    1. Hummel T, Rissom K, Hähner A, Reden J, Weidenbecher M, Hüttenbrink KB. Effects of olfactory training in patients with olfactory loss. Laryngoscope. 2009;119:496–499. doi: 10.1002/lary.20101. Available from: .
    1. Beidler LM, Smallman RL. Renewal of cells within taste buds. J Cell Bio. 1965;27:263–272. doi: 10.1083/jcb.27.2.263. Available from: .
    1. Srur E, Stachs O, Guthoff R, Witt M, Pau HW, Just T. Change of the human taste bud volume over time. Auris Nasus Larynx. 2010;37:449–455. doi: 10.1016/j.anl.2009.11.010. Available from: .
    1. Chaudhari N, Roper SD. The cell biology of taste. J Cell Biol. 2010;190:285–296. doi: 10.1083/jcb.201003144. Available from: .
    1. Behrens M, Reichling C, Batram C, Brockhoff A, Meyerhof W. Bitter taste receptors and their cells. Ann N Y Acad Sci. 2009;1170:111–115. doi: 10.1111/j.1749-6632.2009.03897.x. Available from: .
    1. Bezençon C, le Coutre J, Damak S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses. 2007;32:41–49.
    1. Mojet J, Heidema H, Christ E. Sensitivity to the basic tastes: the effects of age. Chemical Senses. 1996;21:644.
    1. Doty RL. Gender and reproductive state correlates of taste perception in humans. In: McGill TE, et al., editors. Sex and behaviour: status and prospectus. New York: Plenum; 1978.
    1. Beidler LM. Saliva. In: Doty RL, editor. Handbook of olfaction and gustation. New York: Marcel Dekker; 1995.
    1. Small DM, Jones-Gotman M, Zatorre RJ, Petrides M, Evans AC. Flavor processing: more than the sum of its parts. Neuroreport. 1997;8:3913–3917. doi: 10.1097/00001756-199712220-00014. Available from: .
    1. Welge-Lüssen A, Dörig P, Wolfensberger M, Krone F, Hummel T. A study about the frequency of taste disorders. J Neurol. 2011 Mar;258(3):386–392. doi: 10.1007/s00415-010-5763-5. Available from: .
    1. Grant R, Miller S, Simpson D, Lamey PJ, Bone I. The effect of chorda tympani section on ipsilateral and contralateral salivary secretion and taste in man. J Neurol Neurosurg Psychiatry. 1989;52:1058–1062. doi: 10.1136/jnnp.52.9.1058. Available from: .
    1. Saito T, Manabe Y, Shibamori Y, Yamagishi T, Igawa H, Tokuriki M, Fukuoka Y, Noda I, Ohtsubo T, Saito H. Long-term follow-up results of electrogustometry and subjective taste disorder after middle ear surgery. Laryngoscope. 2001;111:2064–2070. doi: 10.1097/00005537-200111000-00037. Available from: .
    1. Nakazato Y, Imai K, Abe T, Tamura N, Shimazu K. Unpleasant sweet taste: a symptom of SIADH caused by lung cancer. J Neurol Neurosurg Psychiatry. 2006;77:405–406. doi: 10.1136/jnnp.2005.073726. Available from: .
    1. Heckmann JG, Lang CJ. Neurological causes of taste disorders. Adv Otorhinolaryngol. 2006;63:255–264. doi: 10.1159/000093764. Available from: .
    1. Bull TR. Taste and the chorda tympani. J Larnygol Otol. 1965;79:479–493. doi: 10.1017/S0022215100063969. Available from: .
    1. Ackerman BH, Kasbekar N. Disturbances of taste and smell induced by drugs. Pharmacotherapy. 1997;17:482–496.
    1. Doty RL, Bromley SM. Effects of drugs on olfaction and taste. Otolaryngol Clin North Am. 2004;37:1229–1254. doi: 10.1016/j.otc.2004.05.002. Available from: .
    1. Grushka M, Epstein JB, Gorsky M. Burning mouth syndrome and other oral sensory disorders: A unifying hypothesis. Pain Res Manag. 2003;8:133–135.
    1. Forabosco A, Criscuolo M, Coukos G, Uccelli E, Weinstein R, Spinato S, Botticelli A, Volpe A. Efficacy of hormone replacement therapy in postmenopausal women with oral discomfort. Oral Surg Oral Med Oral Pathol. 1992;73:570–574. doi: 10.1016/0030-4220(92)90100-5. Available from: .
    1. Landis BN, Just T. Schmeckstörungen. In: Hummel, T, Welge-Luessen A, editors. Riech- und Schmeckstörungen. Stuttgart: Georg Thieme Verlag KG; 2009.
    1. Landis BN, Leuchter I, San Millán Ruíz D, Lacroix JS, Landis T. Transient hemiageusia in cerebrovascular lateral pontine lesions. J Neurol Neurosurg Psychiatry. 2006;77:680–683. doi: 10.1136/jnnp.2005.086801. Available from: .
    1. Gudziol H, Hummel T. Normative values for the assessment of gustatory function using liquid tastants. Acta Otolaryngol. 2007;127:658–661. doi: 10.1080/00016480600951491. Available from: .
    1. Tomita H. Methods in taste examination. In: Surjan L, Bodo G, editors. Proc XIIth ORL World Congr, Budapest, Hungary, 1981. Amsterdam, Oxford: Excerpta Medica; 1982.
    1. Mueller C, Kallert S, Renner B, Stiassny K, Temmel AF, Hummel T, Kobal G. Quantitative assessment of gustatory function in a clinical context using impregnated "taste strips". Rhinology. 2003;41:2–6.
    1. Landis BN, Welge-Luessen A, Brämerson A, Bende M, Mueller CA, Nordin S, Hummel T. "Taste Strips" - a rapid, lateralized, gustatory bedside identification test based on impregnated filter papers. J Neurol. 2009;256:242–248. doi: 10.1007/s00415-009-0088-y. Available from: .
    1. Delwiche JF, Halpern BP, Lee MY. A comparison of tip of the tongue and sip and spit screening procedures. Food Qual P. 1996;7:293–297. doi: 10.1016/S0950-3293(96)00008-0. Available from: .
    1. Henkin RI, Gill JR, Bartter FC. Studies on taste thresholds in normal man and in patients with adrenal cortical insufficiency: the role of acrenal cortical steroids and serum sodium concentration. J Clin Invest. 1963;42:727–735. doi: 10.1172/JCI104765. Available from: .
    1. Murphy C, Quinonez C, Nordin S. Reliability and validity of electrogustometry and its application to young and elderly persons. Chem Senses. 1995;10:499–503. doi: 10.1093/chemse/20.5.499. Available from: .
    1. Hummel T, Genow A, Landis BN. Clinical assessment of human gustatory function using event related potentials. J Neurol Neurosurg Psychiatry. 2010;81:459–464. doi: 10.1136/jnnp.2009.183699. Available from: .
    1. Hummel C, Frasnelli J, Gerber J, Hummel T. Cerebral processing of gustatory stimuli in patients with taste loss. Behav Brain Res. 2007;185:59–64. doi: 10.1016/j.bbr.2007.07.019. Available from: .
    1. Brandt H, Hauswald B, Langer H, Gleditsch J, Zahnert T. Wirksamkeit der Akupunktur bei der Therapie von idiopathischen Schmeckstörungen. Dt Zeitschr Akupunktur. 2008;51:24–31.
    1. Heckmann SM, Hujoel P, Habiger S, Friess W, Wichmann M, Heckmann JG, Hummel T. Zinc gluconate in the treatment of dysgeusia – a randomized clinical trial. J Dent Res. 2005;84:35–38. doi: 10.1177/154405910508400105. Available from: .
    1. Sakagami M, Ikeda M, Tomita H, Ikui A, Aiba T, Takeda N, Inokuchi A, Kurono Y, Nakashima M, Shibasaki Y, Yotsuya O. A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study. Acta Otolaryngol. 2008;26:1–6.
    1. Barker KE, Batstone MD, Savage NW. Comparison of treatment modalities in burning mouth syndrome. Aust Dent J. 2009;54:300–305. doi: 10.1111/j.1834-7819.2009.01154.x. Available from: .
    1. Hampf G, Aalberg V, Sunden B. Experiences from a facial pain unit. J Craniomand Cont Dent Ed. 1990;114:267–272.
    1. Heckmann SM, Heckmann JG, Ungethum A, Hujoel P, Hummel T. Gabapentin has little or no effect in the treatment of burning mouth syndrome - results of an open-label pilot study. Eur J Neurol. 2006;13:e6–e7. doi: 10.1111/j.1468-1331.2006.01294.x. Available from: .

Source: PubMed

3
Suscribir