Switching from fetal to adult hemoglobin
Xunde Wang, Swee Lay Thein, Xunde Wang, Swee Lay Thein
Abstract
The switch from fetal to adult hemoglobin relies on repression or silencing of the upstream γ-globin gene, but identification of the transcriptional repressors that bind to the sites at which a cluster of naturally occurring variants associated with HPFH (hereditary persistence of fetal hemoglobin) are found has been elusive. A new study provides mechanistic evidence for the direct binding of BCL11A and ZBTB7A, two previously identified γ-globin gene repressors.
Conflict of interest statement
Competing interests
The authors declare no competing interests.
Figures
Source: PubMed