Macular Pigment Optical Density in Healthy Subjects
The macular pigment (MP) in humans consists of the yellow, blue-absorbing carotenoids lutein and zeaxanthin, which are contained in vegetables and fruits. The highest concentrations of lutein and zeaxanthin are found in the fovea. Since light entering the eye passes through the MP before reaching the photo receptors it absorbs a significant portion of short-wavelength light. There is evidence that these absorbing properties of the MP as well as the ability of inactivating highly reactive oxygen species are protective for the retina.
Measurement of macular pigment is difficult and the investigators have recently proposed a way of measuring macular pigment optical density (MPOD) based on optical reflectometry. There is increased interest in these measurements in the recent years, because a number of studies has provided evidence that low fruit and vegetable consumption increases the risk of age related macular degeneration (AMD). The present study investigates MP optical density (OD) in healthy volunteers and is used to form a database.
Furthermore the nutritional habits and the influence on MP density will be evaluated.
Aperçu de l'étude
Statut
Les conditions
Type d'étude
Inscription (Réel)
Contacts et emplacements
Lieux d'étude
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Vienna, L'Autriche, 1090
- Department of Clinical Pharmacology, Medical University of Vienna
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Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
Méthode d'échantillonnage
Population étudiée
La description
Inclusion Criteria:
- Healthy subjects without any signs of AMD
- Age between 18 and 90 years, (20 subjects aged between 18 and 40, 20 subjects aged between 41 and 50, 20 subjects aged between 51 and 60, 20 subjects aged between 61 and 70, 20 subjects aged between 71 and 80, 20 subjects aged between 81 and 90)
- Clear non-lenticular ocular media
- Visual acuity > 0.6
Exclusion Criteria:
- Any sign of AMD, or another retinal or optic nerve head disease
- Ocular surgery within the last 6 months
- Treatment with photosensitizing drugs
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
Cohortes et interventions
Groupe / Cohorte |
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1
20 healthy subjects between 18 and 40 years
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2
20 healthy subjects between 41 and 50 years
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3
20 healthy subjects between 51 and 60 years
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20 healthy subjects between 61 and 70 years
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20 healthy subjects between 71 and 80 years
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20 healthy subjects between 81 and 90 years
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Délai |
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MPOD as measured with optical reflectometry
Délai: 1 year
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1 year
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Collaborateurs et enquêteurs
Parrainer
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- OPHT-310109
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