Biomarkers for Muscle Function and Aging in Chronic HIV Infection (MATCH)

Group 1: 66 HIV+ (both men and women), 50 through 65 years of age, on effective antiretroviral therapy (ART).

Group 2: 94 HIV- (both men and women), 50 through 65 years of age.

Inclusion Criteria:

Group 1: HIV positive subjects

• HIV positive
• English speaking
• 50-65 years old
• On Antiretroviral therapy and an HIV viral load below 200 copies/ml
• CD4 equal to or greater than 350 cells/mm3
• Postmenopausal (women)
• Lower extremity mobility sufficient to participate in functional assessment.

Group 2: HIV negative subjects Inclusion Criteria for Group 2 subjects

• English speaking
• 50-65 years old
• Negative for HIV (based on an HIV antibody test at Study Visit 1)
• Matched to Group 1 for sex (50% W, 50% M) and age (50 - 65yo)
• Postmenopausal (women)
• Lower extremity mobility sufficient to participate in functional assessment.

Exclusion Criteria:

Exclusion Criteria for Group 1 Subjects

• Acute or serious illness within 60 days prior to entry
• Use of pharmacologic doses of corticosteroids in the past 6 months.
• Use of anabolic therapy in the past 6 months.
• Lower extremity mobility insufficient to participate in functional assessment.
• Current use (last 30 days) of anticoagulants or known bleeding disorder.

Exclusion Criteria for Group 2 subjects

• Acute or serious illness within 60 days prior to entry
• Use of pharmacologic doses of corticosteroids in the past 6 months
• Use of anabolic therapy in the past 6 months
• Lower extremity mobility insufficient to participate in functional assessment
• Current use (last 30 days) of anticoagulants or known bleeding disorder.