Effect of Myofeedback and Neuromuscular Electrical Stimulation on Hemiplegic Children After Brain Tumor Resection
17 maggio 2026 aggiornato da: Amr Mohamed Sabry Lotfi Amer, Cairo University
This study was conducted to compare between the effect of neuromuscular electrical stimulation and myofeedback on upper limb function, muscle activity and brain derived neurotropic factor in blood for children with hemiplegia after brain tumor surgery.
Panoramica dello studio
Stato
Completato
Condizioni
Descrizione dettagliata
Studies indicate that neuromuscular electrical stimulation is more effective than voluntary exercise in enhancing serum Brain-derived neurotrophic factor levels and improving muscle strength and mobility in children with conditions like cerebral palsy and spinal muscular atrophy.
Myofeedback, particularly surface electromyography biofeedback, is beneficial for upper extremity function post-stroke, as it helps raise awareness and control of movements.
Intensive electromyography biofeedback has shown significant recovery in hemiplegic children compared to traditional therapy.
There is potential for a multimodal treatment approach that combines neuromuscular electrical stimulation and biofeedback to mitigate the effects of brain tumors on upper limb function and optimize Brain-derived neurotrophic factor levels.
Tipo di studio
Interventistico
Iscrizione (Effettivo)
45
Fase
- Non applicabile
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
-
-
-
Alexandria, Egitto
- Elmagd physical therapy centres, Teriaq oncology centre and Elite hospital.
-
-
Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
- Bambino
Accetta volontari sani
No
Descrizione
Inclusion Criteria:
- Age 6-14 years post brain tumor surgery children.
- Children's hand use experience questionnaire between 25 and 50 on a scale of units.
- Grade 2 muscle power of wrist, elbow and finger extensors.
- Outpatient children.
- Post-operative brain tumour, which is located in one of the two hemispheres.
- After 6 weeks post-surgery.
- The child can follow orders and instructions.
Exclusion Criteria:
- Blindness.
- Deaf child.
- Skin diseases.
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Separare
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
Comparatore attivo: selected physical therapy program
The control group will undergo a selected physical therapy (PT) program for one hour, three times weekly, over twelve weeks.
|
The program includes push-up exercises, active strength training for wrist extensors using fine motor toys, stretching for wrist and elbow flexors and pronators, weight-bearing positions from side sitting, quadruped position with active limb elevation, rolling a small ball with the affected limb, and rhythmic muscle approximation for shoulder, elbow, and wrist.
|
|
Sperimentale: selected physical therapy program and biofeedback
Patient will undergo a selected physical therapy program for one hour, three times a week, for twelve weeks, supplemented by a biofeedback program.
|
The program includes push-up exercises, active strength training for wrist extensors using fine motor toys, stretching for wrist and elbow flexors and pronators, weight-bearing positions from side sitting, quadruped position with active limb elevation, rolling a small ball with the affected limb, and rhythmic muscle approximation for shoulder, elbow, and wrist.
During sessions, the child sits with an arm resting on a table, with electrodes placed on the wrist extensors and forearm.
The treatment involves gradually increasing the intensity of faradic current to induce muscle contraction.
Each session lasts 30 minutes to one hour, with treatments up to three times daily, using a frequency of 50-100 Hz and a pulse duration of 0.1-1 ms, for a duration of 2 weeks to 3 months.
|
|
Sperimentale: selected physical therapy program and neuromuscular electric stimulation
The child will participate in a physical therapy program for one hour, three times a week, over twelve weeks, supplemented by neuromuscular electric stimulation.
|
The program includes push-up exercises, active strength training for wrist extensors using fine motor toys, stretching for wrist and elbow flexors and pronators, weight-bearing positions from side sitting, quadruped position with active limb elevation, rolling a small ball with the affected limb, and rhythmic muscle approximation for shoulder, elbow, and wrist.
The child will participate in a physical therapy program for one hour, three times a week, over twelve weeks, supplemented by neuromuscular electric stimulation.
During sessions, the child sits with an arm resting on a table, with electrodes placed on the wrist extensors and forearm.
The treatment involves gradually increasing the intensity of faradic current to induce muscle contraction.
Each session lasts 30 minutes to one hour, with treatments up to three times daily, using a frequency of 50-100 Hz and a pulse duration of 0.1-1 ms, for a duration of 2 weeks to 3 months.
|
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Assessment of muscle activity
Lasso di tempo: at baseline and after 12 weeks
|
All children will be assessed using surface electromyography for wrist extensor muscles while sitting, with their upper limbs resting on a desk and utilizing three electrodes.
The ground electrode (black) is placed proximal to the others, the active electrode (yellow) is on the common extensor origin, and the connector (blue) is positioned at least 3 cm distally.
After registering new patient data, the assessment begins via a one-channel surface electromyography setup, recording maximum and mean muscle activity during wrist extension upon pressing the play button.
|
at baseline and after 12 weeks
|
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Assessment of upper limb function
Lasso di tempo: at baseline and after 12 weeks
|
Using the short form of the Bruininks-Oseretsky Test, which includes fourteen selected test items, subtests 1, 2, 3, 4, and 7 are administered.
The child is positioned sitting at a table.
The time taken for each task is noted as part of the proficiency evaluation.
Performance is recorded, and raw scores are converted to point scores using a conversion table.
The better result from two trials for each item is taken, and the total points from the fourteen short items are recorded in the designated area.
|
at baseline and after 12 weeks
|
|
assessment of level of neurotrophic factor
Lasso di tempo: at baseline and after 12 weeks
|
Fasting blood samples were taken in potassium-methylene diamine tetra acetic acid tubes, centrifuged for 15 minutes at 3000 rpm, and the plasma was stored at -80°C before being sent to Myriad RBM for a 190-analyte multiplex immunoassay.
Additionally, the Brain-derived neurotrophic factor enzyme-linked immunosorbent assay reliably measures whole blood Brain-derived neurotrophic factor with high reproducibility.
|
at baseline and after 12 weeks
|
|
assessment of dynamic spasticity of wrist and elbow flexors muscles
Lasso di tempo: at baseline and after 12 weeks
|
Dynamic spasticity of wrist and elbow flexors muscles will be analyzed at the study's start and end.
Measurements will include resistance 1 (fast velocity movement through full range of motion to identify the point of catch), resistance 2 (passive range of motion), and the difference resistance 2-resistance 1 (dynamic spasticity component).
The Modified Ashworth Scale serves as a clinical tool for assessing spasticity, employing quantitative measurements at two speeds: slow (resistance 2) and fast (resistance 1).
|
at baseline and after 12 weeks
|
Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
1 luglio 2024
Completamento primario (Effettivo)
1 giugno 2025
Completamento dello studio (Effettivo)
1 settembre 2025
Date di iscrizione allo studio
Primo inviato
17 maggio 2026
Primo inviato che soddisfa i criteri di controllo qualità
17 maggio 2026
Primo Inserito (Effettivo)
26 maggio 2026
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
26 maggio 2026
Ultimo aggiornamento inviato che soddisfa i criteri QC
17 maggio 2026
Ultimo verificato
1 maggio 2026
Maggiori informazioni
Termini relativi a questo studio
Termini MeSH pertinenti aggiuntivi
- Manifestazioni neurologiche
- Malattie del sistema nervoso
- Paralisi
- Condizioni patologiche, segni e sintomi
- Segni e sintomi
- Emiplegia
- Terapie
- Terapie mind-body
- Terapie complementari
- Terapia comportamentale
- Psicoterapia
- Discipline e attività comportamentali
- Feedback, psicologico
- Biofeedback, psicologia
Altri numeri di identificazione dello studio
- Amr-phd
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
No
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
No
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .
Prove cliniche su selected physical therapy program
-
Dr. Mohammad Auais, PhDReclutamentoFratture dell'ancaCanada