Evidence of a strong association between frequency of self-monitoring of blood glucose and hemoglobin A1c levels in T1D exchange clinic registry participants

Abstract

Objective: Despite substantial evidence of the benefit of frequent self-monitoring of blood glucose (SMBG) in type 1 diabetes, certain insurers limit the number of test strips that they will provide. The large database of the T1D Exchange clinic registry provided an opportunity to evaluate the relationship between the number of SMBG measurements per day and HbA1c levels across a wide age range of children and adults.

Research design and methods: The analysis included 20,555 participants in the T1D Exchange clinic registry with type 1 diabetes ≥1 year and not using a continuous glucose monitor (11,641 younger than age 18 years and 8,914 18 years old or older). General linear models were used to assess the association between the number of SMBG measurements and HbA1c levels after adjusting for potential confounding variables.

Results: A higher number of SMBG measurements per day were associated with non-Hispanic white race, insurance coverage, higher household income, and use of an insulin pump for insulin delivery (P < 0.001 for each factor). After adjusting for these factors, a higher number of SMBG measurements per day was strongly associated with a lower HbA1c level (adjusted P < 0.001), with the association being present in all age-groups and in both insulin pump and injection users.

Conclusions: There is a strong association between higher SMBG frequency and lower HbA1c levels. It is important for insurers to consider that reducing restrictions on the number of test strips provided per month may lead to improved glycemic control for some patients with type 1 diabetes.

Figures

Figure 1

A: Association between frequency of SMBG per day and HbA1c. Solid black line and diamonds represent those 1 to younger than 13 years old. Solid black line and squares represent those 13 to younger than 26 years old. Solid black line and triangle represent those 26 to younger than 50 years old. Dotted black line and squares represent those 50 years old and older. HbA1c means with numbers <30 are not included here. Means are adjusted for insulin delivery method, sex, race/ethnicity, insurance status, and household income (treated as ordinal variables with a missing indicator). B: Association between frequency of SMBG per day and HbA1c among insulin pump users. Solid black line and diamonds indicate those 1 to younger than 13 years old. Solid black line and squares indicate those 13 to younger than 26 years old. Solid black line and triangle indicate those 26 to younger than 50 years old. Dotted black line and squares indicate those 50 years old or older. HbA1c means with numbers <30 are not included here. Means are adjusted for sex, race/ethnicity, insurance status, and household income (treated as ordinal variables with a missing indicator). C: Association between frequency of SMBG per day and HbA1c among injection users. Solid black line and diamonds represent those 1 to younger than 13 years old. Solid black line and squares represent those 13 to younger than 26 years old. Solid black line and triangle represent those 26 to younger than 50 years old. Dotted black line and squares represent those 50 years old and older. HbA1c means with numbers <30 are not included here. Means are adjusted for sex, race/ethnicity, insurance status, and household income (treated as ordinal variables with a missing indicator).