Effects of beetroot juice supplementation on intermittent high-intensity exercise efforts

Raúl Domínguez, José Luis Maté-Muñoz, Eduardo Cuenca, Pablo García-Fernández, Fernando Mata-Ordoñez, María Carmen Lozano-Estevan, Pablo Veiga-Herreros, Sandro Fernandes da Silva, Manuel Vicente Garnacho-Castaño, Raúl Domínguez, José Luis Maté-Muñoz, Eduardo Cuenca, Pablo García-Fernández, Fernando Mata-Ordoñez, María Carmen Lozano-Estevan, Pablo Veiga-Herreros, Sandro Fernandes da Silva, Manuel Vicente Garnacho-Castaño

Abstract

Beetroot juice contains high levels of inorganic nitrate (NO3-) and its intake has proved effective at increasing blood nitric oxide (NO) concentrations. Given the effects of NO in promoting vasodilation and blood flow with beneficial impacts on muscle contraction, several studies have detected an ergogenic effect of beetroot juice supplementation on exercise efforts with high oxidative energy metabolism demands. However, only a scarce yet growing number of investigations have sought to assess the effects of this supplement on performance at high-intensity exercise. Here we review the few studies that have addressed this issue. The databases Dialnet, Elsevier, Medline, Pubmed and Web of Science were searched for articles in English, Portuguese and Spanish published from 2010 to March 31 to 2017 using the keywords: beet or beetroot or nitrate or nitrite and supplement or supplementation or nutrition or "sport nutrition" and exercise or sport or "physical activity" or effort or athlete. Nine articles fulfilling the inclusion criteria were identified. Results indicate that beetroot juice given as a single dose or over a few days may improve performance at intermittent, high-intensity efforts with short rest periods. The improvements observed were attributed to faster phosphocreatine resynthesis which could delay its depletion during repetitive exercise efforts. In addition, beetroot juice supplementation could improve muscle power output via a mechanism involving a faster muscle shortening velocity. The findings of some studies also suggested improved indicators of muscular fatigue, though the mechanism involved in this effect remains unclear.

Keywords: Beet; Ergogenic aids; Exercise; Sport supplement.

Conflict of interest statement

Not applicable.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Conversion of NO3− in beetroot juice to NO. The diagram shows how ingested NO3− is transformed by bacteria in the mouth containing nitrite reductase to NO2−. Once in the gut, NO2− enters the bloodstream and, under conditions of hypoxia, is used to generate NO
Fig. 2
Fig. 2
Article selection

References

    1. Paton CD, Hopkins WG. Variation in performance of elite cyclists from race to race. Eur J Sport Sci. 2006;6:25–31. doi: 10.1080/17461390500422796.
    1. Koncic MZ, Tomczyk M. New insights into dietary supplements used in sport: active substances, pharmacological and side effects. Curr Drug Targets. 2013;14:1079–1092. doi: 10.2174/1389450111314090016.
    1. Australian Institute of Sport. ABCD classification system. 2017. Available online: (Accessed on 11 Apr 2017).
    1. Burke LM. Practical issues in evidence-based use of performance supplements: supplement interactions, repeated use and individual responses. Sports Med. 2017;47:79–100. doi: 10.1007/s40279-017-0687-1.
    1. Close GL, Hamilton L, Philps A, Burke L, Morton JP. New strategies in sport nutrition to increase exercise performance. Free Radic Biol Med. 2016;5:30–37.
    1. Burnley B, Jones AM. Oxygen uptake kinetics as a determinant of sports performance. Eur J Sport Sci. 2007;7:63–79. doi: 10.1080/17461390701456148.
    1. Morton RH. The critical power and related whole-body bioenergetic models. Europ J Appl Physiol. 2006;96:339–354. doi: 10.1007/s00421-005-0088-2.
    1. Chamari K, Padulo J. ‘Aerobic’ and ‘anaerobic’ terms used in exercise physiology: a critical terminology reflection. Sports Med Open. 2015;1:9. doi: 10.1186/s40798-015-0012-1.
    1. Gaitanos GC, Williams C, Boobis LH, Brooks S. Human muscle metabolism during intermittent maximal exercise. J Appl Physiol. 1993;75:712–719. doi: 10.1152/jappl.1993.75.2.712.
    1. Chamari K, Ahmaidi S, Blum JY, Hue O, Temfemo A, Hertogh C, et al. Venous blood lactate increase after vertical jumping in volleyball athletes. Eur J Appl Physiol. 2001;85:191–194. doi: 10.1007/s004210100415.
    1. Spencer MR, Gastin PB. Energy system contribution during 200- to 1500-m running in highly trained athletes. Med Sci Sports Exerc. 2001;33:157–162. doi: 10.1097/00005768-200101000-00024.
    1. Jones AM. Influence of dietary nitrate on the physiological determinants of exercise performance: a critical review. Appl Physiol Nutr Metab. 2014;39:1019–1028. doi: 10.1139/apnm-2014-0036.
    1. Stamler JS, Meissner G. Physiology of nitric oxide in skeletal muscle. Physiol Rev. 2009;81:209–237. doi: 10.1152/physrev.2001.81.1.209.
    1. Lundberg JO, Weitzberg E. NO-synthase independent NO generation in mammals. Biochem Biophys Res Commun. 2010;396:39–45. doi: 10.1016/j.bbrc.2010.02.136.
    1. Potter L, Angove H, Richardson D, Cole J. Nitrate reduction in the periplasm of gram-negative bacteria. Adv Microb Physiol. 2001;45:51–112. doi: 10.1016/S0065-2911(01)45002-8.
    1. Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008;7:156–167. doi: 10.1038/nrd2466.
    1. Raat NJ, Shiva S, Gladwin MT. Effects of nitrite on modulating ROS generation following ischemia and reperfusion. Adv Drug Deliv. 2009;61:339–350. doi: 10.1016/j.addr.2009.02.002.
    1. Lundberg JO, Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med. 2004;37:395–400. doi: 10.1016/j.freeradbiomed.2004.04.027.
    1. Larsen FJ, Ekblom B, Lundberg JO, Weitzberg E. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol. 2007;191:59–66. doi: 10.1111/j.1748-1716.2007.01713.x.
    1. Ferguson SK, Hirai DM, Copp SW, Holdsworth CT, Allen JD, Jones AM, et al. Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats. J Physiol. 2013;591:547–557. doi: 10.1113/jphysiol.2012.243121.
    1. Ignarro LJ, Adams JB, Horowitz PM. Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. J Biol Chem. 1986;261:4997–5002.
    1. Furchgott R, Jothianandan D. Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessels. 1991;28:52–61.
    1. Erzurum SC, Ghosh S, Janocha AJ, Xu W, Bauer S, Bryan NS, et al. Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proc Natl Acad Sci U S A. 2007;104:17593–17598. doi: 10.1073/pnas.0707462104.
    1. Puype J, Ramaekers M, Thienen R, Deldicque L, Hespel P. No effect of dietary nitrate supplementation on endurance training in hypoxia. Scand J Med Sci Sports. 2015;25:234–241. doi: 10.1111/sms.12199.
    1. Tong L, Heim RA, Wu S. Nitric oxide: a regulator of eukaryotic initiation factor 2, kinases. Free Radic Biol Med. 2011;50:1717–1725. doi: 10.1016/j.freeradbiomed.2011.03.032.
    1. Dejam A, Hunter C, Schechter A, Gladwin M. Emerging role of nitrite in human biology. Blood Cells Mol Dis. 2004;32:423–429. doi: 10.1016/j.bcmd.2004.02.002.
    1. Pinna M, Roberto S, Milia R, Maronquiu E, Olla S, Loi A. Effect of beetroot juice supplementation on aerobic response during swimming. Nutrients. 2014;6:605–615. doi: 10.3390/nu6020605.
    1. Handzlik L, Gleeson M. Likely additive Ergogenic effects of combined Preexercise dietary nitrate and caffeine ingestion in trained cyclists. ISRN Nutr. 2013:396581. 10.5402/2013/396581.
    1. Boorsma RK, Whitfield SL. Beetroot juice supplementation does not improve performance of elite 1500-m runners. Med Sci Sports Exerc. 2014;46:2326–2334. doi: 10.1249/MSS.0000000000000364.
    1. Arnold J, James L, Jones T, Wylie L, Macdonald J. Beetroot juice does not enhance altitude running performance in well-trained athletes. Appl Physiol Nutr Metab. 2015;40:590–595. doi: 10.1139/apnm-2014-0470.
    1. MacLeod KE, Nugent SF, Barr S, Khoele MS, Sporer BC, Maclnnis MJ. Acute beetroot juice supplementation does not improve cycling performance in Normoxia or moderate hypoxia. Int J Sport Nutr Exerc Metab. 2015;25:359–366. doi: 10.1123/ijsnem.2014-0129.
    1. Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, et al. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010;299:1121–1131. doi: 10.1152/ajpregu.00206.2010.
    1. Lansley KE, Winyard PG, Bailey SJ, Vanhatalo A, Wilkerson DP, Blackwell JR, et al. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc. 2011;43:1125–1131. doi: 10.1249/MSS.0b013e31821597b4.
    1. Cermak N, Gibala M, Van Loon J. Nitrate Supplementation’s improvement of 10-km time-trial performance in trained cyclists. Int J Sport Nutr Exerc Metab. 2012;22:64–71. doi: 10.1123/ijsnem.22.1.64.
    1. Wilkerson DP, Hayward GM, Bailey SJ, Vanhatalo A, Blackwell JR, Jones AM. Influence of acute dietary nitrate supplementation on 50 mile time trial performance in well-trained cyclists. Eur J Appl Physiol. 2012;112:4127–4134. doi: 10.1007/s00421-012-2397-6.
    1. Breese BC, McNarry MA, Marwood S, Blackwell JR, Bailey SJ, Jones AM. Beetroot juice supplementation speeds O2 uptake kinetics and improves exercise tolerance during severe-intensity exercise initiated from an elevated metabolic rate. Am J Physiol Regul Integr Comp Physiol. 2013;305:1441–1450. doi: 10.1152/ajpregu.00295.2013.
    1. Kelly J, Vanhatalo A, Wilkerson D, Wylie L, Jones AM. Effects of nitrate on the power-duration relationship for severe-intensity exercise. Med Sci Sports Exerc. 2013;45:1798–1806. doi: 10.1249/MSS.0b013e31828e885c.
    1. Muggeridge DJ, Howe CF, Spendiff O, Pedlar C, James PE, Easton C. The effects of a single dose of concentrated beetroot juice on performance in trained Flatwater kayakers. Int J Sport Nutr Exerc Metab. 2013;23:498–506. doi: 10.1123/ijsnem.23.5.498.
    1. Kelly J, Vanhatalo A, Bailey SJ, Wylie LJ, Tucker C, List S, et al. Dietary nitrate supplementation: effects on plasma nitrite and pulmonary O2 uptake dynamics during exercise in hypoxia and normoxia. Am J Physiol Regul Integr Comp Physiol. 2014;307:920–930. doi: 10.1152/ajpregu.00068.2014.
    1. Lane S, Hawley J, Desbrow B, Jones AM, Blackwell J, Ross ML. Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance. Appl Physiol Nutr Metab. 2014;39:1050–1057. doi: 10.1139/apnm-2013-0336.
    1. Muggeridge DJ, Howe C, Spendiff O, Pedlar C, James P, Easton C. A single dose of beetroot juice enhances cycling performance in simulated altitude. Med Sci Sports Exerc. 2014;46:143–150. doi: 10.1249/MSS.0b013e3182a1dc51.
    1. Thompson K, Turnerb L, Prichardb J, Doddb F, Kennedyb D, Haskellb C, et al. Influence of dietary nitrate supplementation on physiological and cognitive responses to incremental cycle exercise. Respir Physiol Neurobiol. 2014;193:11–20. doi: 10.1016/j.resp.2013.12.015.
    1. Glaister M, Pattison JR, Muniz-Pumares D, Patterson SD, Foley P. Effects of dietary nitrate, caffeine, and their combination on 20-km cycling time trial performance. J Strength Cond Res. 2015;29:165–174. doi: 10.1519/JSC.0000000000000596.
    1. Peeling P, Cox G, Bullock N, Burke L. Beetroot juice improves on-water 500 M time-trial performance, and laboratory-based paddling economy in national and international-level kayak athletes. Int J Sport Nutr Exerc Metab. 2015;25:278–284. doi: 10.1123/ijsnem.2014-0110.
    1. Whitfield J, Ludzki A, Heigenhauser G, Senden S, Verdijk L, Van L, et al. Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle. J Physiol. 2016;594:421–435. doi: 10.1113/JP270844.
    1. Bescós R, Sureda A, Tur JA, Pons A. The effect of nitric-oxide-related supplements on human performance. Sports Med. 2012;42:1–19. doi: 10.2165/11596860-000000000-00000.
    1. Hoon MW, Johnson NA, Chapman PG, Burke LM. The effect of nitrate supplementation on exercise performance in healthy individuals: a systematic review and meta-analysis. Int J Sport Nutr Exerc Metab. 2013;23:522–532. doi: 10.1123/ijsnem.23.5.522.
    1. Clements WT, Lee SR, Bloomer RJ. Nitrate ingestion: a review of the health and physical performance effects. Nutrients. 2014;6:5224–5264. doi: 10.3390/nu6115224.
    1. Pawlak-Chaouch M, Boissiere J, Gamelin FX, Cuvelier G, Berthoin S, Aucouturier J. Effect of dietary nitrate supplementation on metabolic rate during rest and exercise in human: a systematic review and a meta-analysis. Nitric Oxide. 2016;53:65–76. doi: 10.1016/j.niox.2016.01.001.
    1. Domínguez R, Cuenca E, Maté-Muñoz JL, García-Fernández P, Serra-Paya N, Estevan MC, et al. Effects of beetroot juice supplementation on cardiorespiratory endurance in athletes. A systematic review Nutrients. 2017;9:1.
    1. McMahon NF, Leveritt MD, Pavey TG. The effect of dietary nitrate supplementation on endurance exercise performance in healthy adults: a systematic review and meta-analysis. Sports Med. 2017;47:735–756. doi: 10.1007/s40279-016-0617-7.
    1. Hernández A, Schiffer TA, Ivarsson N, Cheng AJ, Bruton JD, Lundberg JO, et al. Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fasttwitch muscle. J Physiol. 2012;590:3575–3583. doi: 10.1113/jphysiol.2012.232777.
    1. Martin K, Smee D, Thompson KG, Rattray B. No improvement of repeated-Sprint performance with dietary nitrate. Int J Sports Physiol Perform. 2014;9:845–850. doi: 10.1123/ijspp.2013-0384.
    1. Aucouturier J, Boissiere J, Pawlak-Chaouch M, Cuvelier G, Gamelin FX. Effect of dietary nitrate supplementation on tolerance to supramaximal intensity intermittent exercise. Nitric Oxide. 2015;49:16–25. doi: 10.1016/j.niox.2015.05.004.
    1. Buck CL, Henry T, Guelfi K, Dawson B, McNaughton LR, Wallman K. Effects of sodium phosphate and beetroot juice supplementation on repeated-sprint ability in females. Eur J Appl Physiol. 2015;115:2205–2213. doi: 10.1007/s00421-015-3201-1.
    1. Thompson C, Wylie LJ, Fulford J, Kelly J, Black MI, McDonagh STJ, et al. Dietary nitrate improves sprint performance and cognitive function during prolonged intermittent exercise. Eur J Appl Physiol. 2015;115:1825–1834. doi: 10.1007/s00421-015-3166-0.
    1. Clifford T, Berntzen B, Davison GW, West DJ, Howatson G, Stevenson EJ. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated Sprint exercise. Nutrients. 2016;8:506. doi: 10.3390/nu8080506.
    1. Mosher SL, Sparks SA, Williams EL, Bentley DJ, McNaughton LR. Ingestion of a nitric oxide enhancing supplement improves resistance exercise performance. J Strength Cond Res. 2016;30:3520–3524. doi: 10.1519/JSC.0000000000001437.
    1. Rimer EG, Peterson LR, Coggan AR, Martin JC. Increase in maximal cycling power with acute dietary nitrate supplementation. Int J Sports Physiol Perform. 2016;11:715–720. doi: 10.1123/ijspp.2015-0533.
    1. Wylie LJ, Mohr M, Krustrup P, Jackman SR, Ermιdis G, Kelly J, et al. Dietary nitrate supplementation improves team sport-specific intense intermittent exercise performance. Eur J Appl Physiol. 2013;113:1673–1684. doi: 10.1007/s00421-013-2589-8.
    1. Domínguez R, Garnacho-Castaño MV, Maté-Muñoz JL. Efectos del entrenamiento contra resistencias o resistance training en diversas patologías. Nutr Hosp. 2016;33:719–733. doi: 10.20960/nh.284.
    1. Ratamess NA, Albar BA, Evetoch TK, Housh TJ, Kibler WB, Kraemer WJ, et al. Special communication. American College of Sports Medicine position stand: progression models in resistance training for healthy adults. Med Sci Sports Exerc. 2009;41:687–708. doi: 10.1249/MSS.0b013e3181915670.
    1. Garnacho-Castaño MV, Domínguez R, Maté-Muñoz JL. Understanding the meaning of the lactate threshold in resistance exercises. Int J Sports Med. 2015;36:371–377. doi: 10.1055/s-0034-1398495.
    1. Garnacho-Castaño MV, Domínguez R, Ruiz-Solano P, Maté-Muñoz JL. Acute physiological and mechanical responses during resistance exercise executed at the lactate threshold workload. J Strength Cond Res. 2015;29:2867–2873. doi: 10.1519/JSC.0000000000000956.
    1. Carr BM, Webster MJ, Boyd JC, Hudson GM, Scheett TP. Sodium bicarbonate supplementation improves hypertrophy-type resistance exercise performance. Eur J Appl Physiol. 2013;113:743–752. doi: 10.1007/s00421-012-2484-8.
    1. Phillips SM. Nutritional supplements in support of resistance exercise to counter age-related sarcopenia. Adv Nutr. 2015;6:452–460. doi: 10.3945/an.115.008367.
    1. Tomlin DL, Wenger HA. The relationship between aerobic fitness and recovery from high intensity intermittent exercise. Sports Med. 2001;31:1–11. doi: 10.2165/00007256-200131010-00001.
    1. Vanhatalo A, Fulford J, Bailey SJ, Blackwell JR, Winyard PG, Jones AM. Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia. J Physiol. 2011;589:5517–5528. doi: 10.1113/jphysiol.2011.216341.
    1. Bloomer JR, Farney TM, Trepanowski JF, McCarthy CG, Canale RE, Schilling BK. Research article comparison of preworkout nitric oxide stimulating dietary supplements on skeletal muscle oxygen saturation, blood nitrate/nitrite, lipid peroxidation, and upper body exercise performance in resistance trained men. J Int Soc Sports Nutr. 2010;7:1–15. doi: 10.1186/1550-2783-7-16.
    1. Spencer M, Bishop D, Dawson B, Goodman C. Physiological and metabolic responses of repeated-sprint activities. Sports Med. 2005;35:1025–1044. doi: 10.2165/00007256-200535120-00003.
    1. O’Donoghue P, Ingram B. A notational analysis of elite tennis strategy. J Sport Sci. 2001;19:107–115. doi: 10.1080/026404101300036299.
    1. Felippe LC, Lopes-Silva JP, Bertuzzi R, McGinley C, Lima-Silva AE. Separate and combined effects of caffeine and sodium-bicarbonate intake on judo performance. Int J Sports Physiol Perform. 2016;11:221–226. doi: 10.1123/ijspp.2015-0020.
    1. Mujika I. Nutrition in team sports. Ann Nutr Metab. 2010;57:26–35. doi: 10.1159/000322700.
    1. Fitzsimons M, Dawson BT, Ward D, Wilkinson A. Cycling and running tests of repeated sprint ability. Aust J Sci Med Sport. 1993;25:82–87.
    1. Krustrup P, Mohr M, Steensberg A, Bencke J, Kjaer M, Bangsbo J. Muscle and blood metabolites during a soccer game: implications for sprint performance. Med Sci Sports Exerc. 2006;38:1165–1174. doi: 10.1249/.
    1. Krustrup P, Söderlund K, Relu MU, Ferguson RA, Bangsbo J. Heterogeneous recruitment of quadriceps muscle portions and fibre types during moderate intensity knee-extensor exercise: effect of thigh occlusion. Scand J Med Sci Sports. 2009;19:576–584. doi: 10.1111/j.1600-0838.2008.00801.x.
    1. Lucía A, Sánchez O, Carvajal A, Chicharro JL. Analysis of the aerobic-anaerobic transition in elite cyclists during incremental exercise with the use of electromyography. Br J Sports Med. 1999;33:178–185. doi: 10.1136/bjsm.33.3.178.
    1. Syrotuik DG, Bell GJ. Acute creatine monohydrate supplementation: a descriptive physiological profile of responders vs. nonresponders. J Strength Cond Res. 2004;18:610–617.
    1. Volek JS, Kraemer WJ. Creatine supplementation: its effect on human muscular performance and body composition. J Strength Cond Res. 1996;10:200–210.
    1. Kendrick IP, Kim HJ, Harris RC, Kim CK, Dang VH, Lam TQ, et al. The effect of 4 weeks b-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibres. Eur J Appl Physiol. 2009;106:131–138. doi: 10.1007/s00421-009-0998-5.
    1. Fulford J, Winyard PG, Vanhatalo A, Bailey SJ, Blackwell JR, Jones AM. Influence of dietary nitrate supplementation on human skeletal muscle metabolism and force production during maximum voluntary contractions. Pflugers Arch. 2013;465:517–528. doi: 10.1007/s00424-013-1220-5.
    1. Wallimann T, Tokarska-Schlattner M, Schlattner U. The creatine kinase system and pleiotropic effects of creatine. Amino Acids. 2011;40:1271–1296. doi: 10.1007/s00726-011-0877-3.
    1. Trivedi B, Daniforth WH. Effect of pH on the kinetics of frog muscle phosphofructokinase. J Biol Chem. 1966;241:4110–4112.
    1. Sahlin K, Harris RC. The creatine kinase reaction: a simple reaction with functional complexity. Amino Acids. 2011;40:1363–1367. doi: 10.1007/s00726-011-0856-8.
    1. Hobson RM, Saunders B, Ball G, Harris RC, Sale C. Effects of beta-alanine supplementation on exercise performance: a review by meta-analysis. Amino Acids. 2012;43:25–37. doi: 10.1007/s00726-011-1200-z.
    1. Messonier L, Kristensen M, Juel C, Denis C. Importance of pH regulation and lactate/H+ transport capacity for work production during supramaximal exercise in humans. J Appl Physiol. 2007;102:1936–1944. doi: 10.1152/japplphysiol.00691.2006.
    1. Sterlingwerff T, Decombaz J, Harris RC, Boesch C. Optimizing human in vivo dosing and delivery of ß-alanine supplements for muscle carnosine synthesis. Amino Acids. 2012;43:57–65. doi: 10.1007/s00726-012-1245-7.
    1. Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids. 2006;30:279–289. doi: 10.1007/s00726-006-0299-9.
    1. Requena B, Zabala M, Padial P, Feriche B. Sodium bicarbonate and sodium citrate: ergogenic aids? J Strength Cond Res. 2005;19:213–224.
    1. Domínguez R, Lougedo JH, Maté-Muñoz JL, Garnacho-Castaño MV. Efectos de la suplementación con β-alanina sobre el rendimiento deportivo. Nutr Hosp. 2015;31:155–169.
    1. Tobias G, Benatti FB, De Salles V, Roschel H, Gualano B, Sale C, et al. Additive effects of beta-alanine and sodium bicarbonate on upper-body intermittent performance. Amino Acids. 2013;45:309–317. doi: 10.1007/s00726-013-1495-z.
    1. Gray SR, Söderlund K, Ferguson RA. ATP and phosphocreatine utilization in single human muscle fibres during the development of maximal power output at elevated muscle temperatures. J Sports Sci. 2008;26:701–707. doi: 10.1080/02640410701744438.
    1. Poole DS, Copp SW, Hirai DM, Musch TI. Dynamics of muscle microcirculatory and blood-myocyte O(2) flux during contractions. Acta Physiol. 2011;202:293–310. doi: 10.1111/j.1748-1716.2010.02246.x.
    1. Bogdanis GC, Nevill ME, Lakomy HK, Graham CM, Louis G. Effects of active recovery on power output during repeated maximal sprint cycling. Eur J Appl Physiol Occup Physiol. 1996;74:461–469. doi: 10.1007/BF02337727.
    1. Haseler LJ, Hogan MC, Richardson RS. Skeletal muscle phosphocreatine recovery in exercise-trained humans is dependent on O2 availability. J Appl Physiol. 1999;86:2013–2018. doi: 10.1152/jappl.1999.86.6.2013.
    1. Martin JC, Brown NA, Anderson FC, Spirduso WW. A governing relationship for repetitive muscular contraction. J Biomech. 2000;33:969–974. doi: 10.1016/S0021-9290(00)00048-8.
    1. Marechal G, Beckers-Bleukx G. Effect of nitric oxide on the maximal velocity of shortening of a mouse skeletal muscle. Pflugers Arch. 1998;436:906–913. doi: 10.1007/s004240050722.
    1. Marechal G, Gailly P. Effects of nitric oxide on the contraction of skeletal muscle. Cell Mol Life Sci. 1999;55:1088–1102. doi: 10.1007/s000180050359.
    1. Kramer SJ, Baur DA, Spicer MT, Vukovich MD, Ormsbee MJ. The effect of six days of dietary nitrate supplementation on performance in trained CrossFit athletes. J Int Soc Sports Nutr. 2016;13:39. doi: 10.1186/s12970-016-0150-y.
    1. Bobbert MF, Van Soest AJ. Why do people jump the way they do? Exerc Sport Sci Rev. 2001;29:95–102. doi: 10.1097/00003677-200107000-00002.
    1. Rodacki ALF, Fowler NE, Bennett SJ. Multi-segment coordination: fatigue effects. Med Sci Sports Exerc. 2001;33:1157–1167. doi: 10.1097/00005768-200107000-00013.
    1. Sánchez-Medina L, González-Badillo JJ. Velocity loss as an indicator of neuromuscular fatigue during resistance training. Med Sci Sports Exerc. 2011;43:1725–1734. doi: 10.1249/MSS.0b013e318213f880.
    1. Rodacki AL, Fowler NE, Bennett SJ. Vertical jump coordination: fatigue effects. Med Sci Sports Exerc. 2002;34:105–116. doi: 10.1097/00005768-200201000-00017.
    1. Mosteiro-Muñoz F, Domínguez R. Effects of inertial overload resistance training on muscle function. Rev Int Med Cienc Act Fís Deporte. 2017;In press.

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