Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes

Abstract

Monocyte Chemoattractant Protein-1 (MCP-1) is the first discovered and most extensively studied CC chemokine, and the amount of studies on its role in the etiologies of obesity- and diabetes-related diseases have increased exponentially during the past two decades. This review attempted to provide a panoramic perspective of the history, regulatory mechanisms, functions, and therapeutic strategies of this chemokine. The highlights of this review include the roles of MCP-1 in the development of obesity, diabetes, cardiovascular diseases, insulitis, diabetic nephropathy, and diabetic retinopathy. Therapies that specifically or non-specifically inhibit MCP-1 overproduction have been summarized.

Copyright © 2012 Elsevier Ltd. All rights reserved.

Figures

Figure 1

A graphical summary of the transcriptional regulatory elements in human MCP-1 gene. TRE, phorbol ester responsive elements. The numbers indicate length in base pair. The schematic illustration is not proportional to the length of the DNA.