The combined effect of parathyroid hormone (1-34) and whole-body vibration exercise on physical performance in OSteoporotic women (PaVOS study): a secondary analysis from a randomised controlled trial

Ditte Beck Jepsen, Tahir Masud, Anders Holsgaard-Larsen, Stinus Hansen, Niklas Rye Jørgensen, Jesper Ryg, Ditte Beck Jepsen, Tahir Masud, Anders Holsgaard-Larsen, Stinus Hansen, Niklas Rye Jørgensen, Jesper Ryg

Abstract

Background: The aim of this study was to investigate the effect on physical performance of combining whole-body vibration exercise (WBV) with parathyroid hormone 1-34 (teriparatide) compared to teriparatide alone.

Methods: A secondary analysis from a RCT where postmenopausal women with severe osteoporosis were randomised to WBV plus teriparatide (intervention) or teriparatide alone (control). WBV was applied three times/week (6x1min WBV:1 min rest, (peak acceleration 3.6 g)) for twelve months. Both groups received teriparatide 20 μg s.c./day. The primary endpoint (bone mineral density) is reported elsewhere. Physical performance measures (Short Physical Performance Battery (SPPB), Timed-Up-and-Go (TUG), leg extension power, and grip strength) were obtained at baseline, three-, six-, and twelve months, lean mass at baseline and twelve months. Data were analysed with mixed linear regression model or robust cluster regression in an intention to treat analysis.

Results: Thirty-five women aged (mean ± SD) 69 ± 7) years were recruited of which thirty-two (91%) completed the twelve months follow-up (WBV + teriparatide = 15, teriparatide = 17). SPPB score (mean ± SD) improved significantly at three months in the WBV + teriparatide group from 9.13 ± 2.03 to 10.35 ± 1.69 (p = 0.014) with a statistical trend towards a between-group change in favor of the WBV + teriparatide group (0.86 [95%CI(- 0.05,1.77), p = 0.065]). Both groups improved in leg extension power during the study period whereas no changes were seen in TUG, grip strength, or lean mass in either group. No statistical significant between-group differences were observed.

Conclusion: WBV may improve some short-term aspects of physical performance in severely osteoporotic postmenopausal women who are receiving teriparatide treatment.

Trial registration: ClinicalTrials.gov, ID:NCT02563353.

Keywords: Exercise; Osteoporosis; Physical performance; Short physical performance battery; Whole-body vibration; Women.

Conflict of interest statement

Competing interestsThe investigators have no competing interests in the study.

© The Author(s) 2020.

Figures

Fig. 1
Fig. 1
Consort flow diagram showing number of subjects screened for study participation and number of participants in each treatment group at baseline, three-, six-, and twelve months of follow-up, with designation of reasons for early discontinuation. The WBV + teriparatide group received whole-body vibration and teriparatide and the teriparatide group received teriparatide alone. WBV whole-body vibration, ITT intention to treat

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