Endothelial cells in allograft rejection
Rafia S Al-Lamki, John R Bradley, Jordan S Pober, Rafia S Al-Lamki, John R Bradley, Jordan S Pober
Abstract
In organ transplantation, blood borne cells and macromolecules (e.g., antibodies) of the host immune system are brought into direct contact with the endothelial cell lining of graft vessels. In this location, graft endothelial cells play several roles in allograft rejection, including the initiation of rejection responses by presentation of alloantigen to circulating T cells; the development of inflammation and thrombosis; and as targets of injury and agents of repair.
Conflict of interest statement
The authors have no conflicts of interest.
Source: PubMed