Intraoperative burst suppression is associated with postoperative delirium following cardiac surgery: a prospective, observational study

Martin Soehle, Alexander Dittmann, Richard K Ellerkmann, Georg Baumgarten, Christian Putensen, Ulf Guenther, Martin Soehle, Alexander Dittmann, Richard K Ellerkmann, Georg Baumgarten, Christian Putensen, Ulf Guenther

Abstract

Background: Postoperative delirium (POD) occurs frequently after cardiac surgery and is associated with increased morbidity and mortality. We analysed whether perioperative bilateral BIS monitoring may detect abnormalities before the onset of POD in cardiac surgery patients.

Methods: In a prospective observational study, 81 patients undergoing cardiac surgery were included. Bilateral Bispectral Index (BIS)-monitoring was applied during the pre-, intra- and postoperative period, and BIS, EEG Asymmetry (ASYM), and Burst Suppression Ratio (BSR) were recorded. POD was diagnosed according to the Confusion Assessment Method for the Intensive Care Unit, and patients were divided into a delirium and non-delirium group.

Results: POD was detected in 26 patients (32%). A trend towards a lower ASYM was observed in the delirium group as compared to the non-delirium group on the preoperative day (ASYM = 48.2 ± 3.6% versus 50.0 ± 4.7%, mean ± sd, p = 0.087) as well as before induction of anaesthesia, with oral midazolam anxiolysis (median ASYM = 49.5%, IQR [47.4;51.5] versus 50.6%, IQR [49.1;54.2], p = 0.081). Delirious patients remained significantly (p = 0.018) longer in a burst suppression state intraoperatively (107 minutes, IQR [47;170] versus 44 minutes, IQR [11;120]) than non-delirious patients. Receiver operating analysis revealed burst suppression duration (area under the curve = 0.73, p = 0.001) and BSR (AUC = 0.68, p = 0.009) as predictors of POD.

Conclusions: Intraoperative assessment of BSR may identify patients at risk of POD and should be investigated in further studies. So far it remains unknown whether there is a causal relationship or rather an association between intraoperative burst suppression and the development of POD.

Trial registration: clinicaltrials.gov NCT01048775.

Figures

Figure 1
Figure 1
Receiver operating characteristic (ROC) analysis of four parameters to predict postoperative delirium. Burst suppression (BS) was assessed on the right side during the period from induction of anaesthesia until the onset of cardiopulmonary bypass. The area under the curve (A) for the parameters BS duration and BS ratio was significantly (p = 0.001 and 0.009 respectively) different from 0.5, whereas the area under the curve for age and ASYM was not. ASYM = EEG asymmetry.
Figure 2
Figure 2
The time course of the EEG-asymmetry (ASYM) in comparison between delirious and non-delirious patients. An ASYM of less or more than 50% indicates more EEG power on the right or left hemisphere, respectively. Cp bypass = cardiopulmonary bypass. Data = mean ± std dev.
Figure 3
Figure 3
The Burst Suppression Ratio (BSR) as observed on the right side during the pre-, intra- and postoperative period. Data obtained in delirious or non-delirious patients are illustrated in red and blue, respectively. Cp bypass = cardiopulmonary bypass. Data = mean ± std dev.

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