Effect of Catgut Embedment in Du Meridian Acupoint on Mental and Psychological Conditions of Patients with Gastroesophageal Reflux Disease

Zhengjie Luo, Xuanming Hu, Chaoming Chen, Lvqun Zhu, Wenyan Zhang, You Shen, Jirou He, Zhengjie Luo, Xuanming Hu, Chaoming Chen, Lvqun Zhu, Wenyan Zhang, You Shen, Jirou He

Abstract

Objective: To observe the influence of the catgut-embedding method in Du Meridian acupoint on the mental and psychological state of patients with gastroesophageal reflux disease (GERD) and analyze its possible mechanism.

Methods: According to the random number table, 60 patients with GERD were randomly divided into groups of acupoint catgut embedding and Western medicine, 30 cases in each group. The acupoint group was given catgut embedment in the positive reaction points along the Du Meridian, while the Western medicine group received lansoprazole tablet. They were both treated for six weeks. Scores of Gastroesophageal Reflux Disease Questionnaire (GerdQ), Zung's Self-Rating Anxiety Scale (SAS), Zung's Self-Rating Depression Scale (SDS), and Health-Related Quality of Life Scale for GERD (GERD-HRQL) were measured before and after treatment to analyze and evaluate the differences of symptom scores and mental and psychological conditions between the two groups.

Results: (1) The scores of GerdQ, GERD-HRQL, SAS, and SDS in the two groups both significantly decreased after treatment (P < 0.05), and those of the acupoint group were much lower than the Western medicine group (P < 0.05). (2) The total effective rate was 90.00% in the acupoint group and 53.33% in the Western medicine group, with a statistically significant difference (P < 0.05). (3) The correlation coefficients r between the GerdQ score and scores of SAS and SDS were 0.563 and 0.322, respectively, and those between the GERD-HRQL score and scores of SAS and SDS were, respectively, 0.506 and 0.435.

Conclusion: (1) The main symptoms of GERD patients, such as acid reflux and heartburn, mental and psychological condition, and quality of life, were all improved in the two groups, but the efficacy in the acupoint group is superior to that of the Western medicine group. (2) The clinical symptoms and scores of patients' quality of life are positively correlated with the degree of their anxiety and depression. (3) The acupoint catgut-embedding method can effectively regulate the anxiety and depressive symptoms of patients, which complements the efficacy of proton-pump inhibitors and benefits a wider range of population.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Copyright © 2020 Zhengjie Luo et al.

Figures

Figure 1
Figure 1
An example of the thread-embedding operation on the back.
Figure 2
Figure 2
Scatter chart of correlation analysis between GerdQ score and scores of SAS and SDS.
Figure 3
Figure 3
Scatter chart of correlation analysis between GERD-HRQL score and scores of SAS and SDS.

References

    1. Kim S. E., Kim N., Oh S., et al. Predictive factors of response to proton pump inhibitors in Korean patients with gastroesophageal reflux disease. Journal of Neurogastroenterology & Motility. 2015;21(1):69–77. doi: 10.5056/jnm14078.
    1. Qu Y., Wang W., Zhang X., et al. The relationship between psychological factors and the incidence of refractory gastroesophageal reflux disease. Chinese Journal of Gastroenterology and Hepatology. 2015;24(12):1445–1447.
    1. Gao X. Clinical features and influence factors of patients with gastroesophageal reflux disease. Chinese Journal of Gastroenterology and Hepatology. 2014;23(11):1267–1270.
    1. Lu M., Zhang J. Clinical observation of 60 cases of depression complicated with gastrointestinal symptoms treated by acupuncture and western medicine at the tenderness point on dorsal segment of du meridian. Journal of Traditional Chinese Medicine. 2017;58(23):2028–2031.
    1. Tian H., Wang L., Zhou Q., et al. Clinical evaluation of acupuncture treatment of insomnia with depression and anxiety. Journal of Traditional Chinese Medicine. 2016;57(22):1929–1933.
    1. Zhang D., Yu C., Xiang W., et al. Clinical observation of gastro-esophageal reflux treated by catgut-embedding underneath the acupoints of governor vessel. Journal of Clinical Acupuncture and Moxibustion. 2017;33(8):38–41.
    1. Feng J., Chen C. Clinical research in governor vessel daogi needing method for treatment of non-erosive reflux disease. Lishizhen Medicine and Materia Medica Research. 2016;27(1):138–140.
    1. Vakil N., van Zanten S. V., Kahrilas P., Dent J., Jones R. The montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. The American Journal of Gastroenterology. 2006;101(8):1900–1920. doi: 10.1111/j.1572-0241.2006.00630.x.
    1. Katz P. O., Gerson L. B., Vela M. F. Guidelines for the diagnosis and management of gastroesophageal reflux disease. American Journal of Gastroenterology. 2013;108(3):308–328. doi: 10.1038/ajg.2012.444.
    1. Zhang J., Wang L. Clinical study on the distribution of tenderness points on dorsal segment of du meridian in depressed patients. Jiangsu Journal of Traditional Chinese Medicine. 2007;39(3):16–18.
    1. Pan S., Li J., Li Y., et al. Overview of the clinical and mechanism of acupuncture treatment of gastroesophageal reflux disease. Journal of Clinical Acupuncture and Moxibustion. 2017;33(1):79–83.
    1. Qi Y., Yan-Dong X., Zhang M.-x., et al. Effect of electroacupuncture stimulation at Zusanli acupoint (ST36) on gastric motility: possible through PKC and MAPK signal transduction pathways. BMC Complementary and Alternative Medicine. 2014;14(1):p. 137. doi: 10.1186/1472-6882-14-137.
    1. Tatewaki M., Harris M., Uemura K., et al. Dual effects of acupuncture on gastric motility in conscious rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2003;285(4):R862–R872. doi: 10.1152/ajpregu.00715.2002.
    1. Jang J.-H., Lee D.-J., Bae C.-H., et al. Changes in small intestinal motility and related hormones by acupuncture stimulation at Zusanli (ST 36) in mice. Chinese Journal of Integrative Medicine. 2017;23(3):215–220. doi: 10.1007/s11655-016-2609-8.
    1. Noguchi E. Mechanism of reflex regulation of the gastroduodenal function by acupuncture. Evidence-Based Complementary and Alternative Medicine. 2008;5(3):251–256. doi: 10.1093/ecam/nem077.
    1. Pilkington K. Acupuncture therapy for psychiatric illness. International Review of Neurobiology. 2013;111:197–216. doi: 10.1016/b978-0-12-411545-3.00010-9.
    1. Huo J., Zhao J., Yuan Y., et al. Research status of the effect mechanism on catgut-point embedding therapy. Chinese Acupuncture & Moxibustion. 2017;37(11):1251–1254.
    1. Koloski N. A., Jones M., Kalantar J., Weltman M., Zaguirre J., Talley N. J. The brain-gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study. Gut. 2012;61(9):1284–1290. doi: 10.1136/gutjnl-2011-300474.
    1. Bao C.-H., Dou C.-Z., Xu B., Liu H.-R., Wu H.-G. Brain-gut interactions and inflammatory bowel disease: implications for acupuncture and moxibustion treatment. World Chinese Journal of Digestology. 2013;21(23):2300–2307. doi: 10.11569/wcjd.v21.i23.2300.
    1. Lu M., Zhang J. Treatment of depression from gastrointestinal tract. Journal of Qingdao University(Medical Sciences) 2016;52(6):746–748.

Source: PubMed

3
Sottoscrivi