Coverage and cost of a large oral cholera vaccination program in a high-risk cholera endemic urban population in Dhaka, Bangladesh
Iqbal Ansary Khan, Amit Saha, Fahima Chowdhury, Ashraful Islam Khan, Md Jasim Uddin, Yasmin A Begum, Baizid Khoorshid Riaz, Sanjida Islam, Mohammad Ali, Stephen P Luby, John D Clemens, Alejandro Cravioto, Firdausi Qadri, Iqbal Ansary Khan, Amit Saha, Fahima Chowdhury, Ashraful Islam Khan, Md Jasim Uddin, Yasmin A Begum, Baizid Khoorshid Riaz, Sanjida Islam, Mohammad Ali, Stephen P Luby, John D Clemens, Alejandro Cravioto, Firdausi Qadri
Abstract
A feasibility study of an oral cholera vaccine was carried out to test strategies to reach high-risk populations in urban Mirpur, Dhaka, Bangladesh. The study was cluster randomized, with three arms: vaccine, vaccine plus safe water and hand washing practice, and no intervention. High risk people of age one year and above (except pregnant woman) from the two intervention arms received two doses of the oral cholera vaccine, Shanchol™. Vaccination was conducted between 17th February and 16th April 2011, with a minimum interval of fourteen days between two doses. Interpersonal communication preceded vaccination to raise awareness amongst the target population. The number of vaccine doses used, the population vaccinated, left-out, drop out, vaccine wastage and resources required were documented. Fixed outreach site vaccination strategy was adopted as the mode of vaccine delivery. Additionally, mobile vaccination sites and mop-up activities were carried out to reach the target communities. Of the 172,754 target population, 141,839 (82%) and 123,666 (72%) received complete first and second doses of the vaccine, respectively. Dropout rate from the first to the second dose was 13%. Two complete doses were received by 123,661 participants. Vaccine coverage in children was 81%. Coverage was significantly higher in females than in males (77% vs. 66%, P<0.001). Vaccine wastage for delivering the complete doses was 1.2%. The government provided cold-chain related support at no cost to the project. Costs for two doses of vaccine per-person were US$3.93, of which US$1.63 was spent on delivery. Cost for delivering a single dose was US$0.76. We observed no serious adverse events. Mass vaccination with oral cholera vaccine is feasible for reaching high risk endemic population through the existing national immunization delivery system employed by the government.
Trial registration: ClinicalTrials.gov NCT01339845.
Keywords: Bangladesh; Cholera vaccine; Complete dose; Endemic high risk targeted population; Feasibility.
Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
Source: PubMed