A research on syndrome element differentiation based on phenomenology and mathematical method

Enliang Yan, Jialin Song, Chaonan Liu, Wenxue Hong, Enliang Yan, Jialin Song, Chaonan Liu, Wenxue Hong

Abstract

Background: As an empirical medical system independent of conventional Western medicine (CWM), over thousands of years, traditional Chinese medicine (TCM) has established its own unique method of diagnosis and treatment. The perspective of holism and system in TCM is essentially different from the view of Reductionism in CWM. With the development of modern science and technology, the restriction of reductionism is more and more prominent, and researchers begin to pay more attention to holistic thinking in TCM. Confronted with the above situation, there is an urgent need to explore the diagnosis of TCM by the techniques of modern science.

Methods: To explore the feasibility of using modern science to describe and realize the diagnosis of TCM, in this paper, a method of syndrome element differentiation based on phenomenology is proposed. The proposed method is implemented by mathematical mapping, and then it is testified through analysis of 670 medical records: Based on the original mapping data between two data sets (set of syndrome elements and set of clinical manifestations), new mapping data is generated, and thus the corresponding quantitative diagnostic results are calculated and evaluated. Finally, knowledge discovery of the diagnosis results based on attribute partial-ordered structure diagram is conducted.

Results: The value order's matching results between original and new results show that the matched degree of each record is no less than 65%, while there are at least 87% records whose matched degree is more than 80%. In addition, the knowledge discoveries of new results are basically identical with the ones of original results as well.

Conclusion: Using phenomenology to describe syndrome differentiation should be feasible, and further research on mapping relations between various sets (symptoms, formulas, drugs) of TCM should be conducted and evaluated through clinical trials in future.

Keywords: Attribute partial-ordered structure diagram; Mathematical mapping; Phenomenology; Syndrome differentiation; Syndrome element; Traditional Chinese medicine.

Figures

Fig. 1
Fig. 1
Mathematical description of phenomenological theory
Fig. 2
Fig. 2
Mathematical description of syndrome element differentiation
Fig. 3
Fig. 3
APOSD of biology and water. a Star style, b Annular style, c Tree style
Fig. 4
Fig. 4
System of data acquisition. a Question of inquiry, b value of syndrome elements, c value orders of syndrome elements
Fig. 5
Fig. 5
Model of syndrome element quantification
Fig. 6
Fig. 6
Evaluation model of mapping weights
Fig. 7
Fig. 7
Contrast of mapping weights. a Mapping weights of asthma (symptom), b mapping weights of yang hyperactivity (element)
Fig. 8
Fig. 8
Contrast of values and value orders of syndrome elements. a Values of elements calculated from all symptoms, b value orders of elements calculated from all symptoms, c values of elements calculated from severe symptoms, d value orders of elements calculated from severe symptoms
Fig. 9
Fig. 9
APOSD of original results
Fig. 10
Fig. 10
APOSD of Symptom_Normal type results
Fig. 11
Fig. 11
Statistical pies of integrated matched degree

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