First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids
Mathieu Luyckx, Jean-Luc Squifflet, Pascale Jadoul, Rafaella Votino, Marie-Madeleine Dolmans, Jacques Donnez, Mathieu Luyckx, Jean-Luc Squifflet, Pascale Jadoul, Rafaella Votino, Marie-Madeleine Dolmans, Jacques Donnez
Abstract
Objective: To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.
Design: Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.
Setting: Academic hospital.
Patient(s): Among the 52 patients, 21 wished to conceive upon treatment completion.
Intervention(s): None.
Main outcome measure(s): Pregnancy rate and live birth rate.
Result(s): Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy.
Conclusion(s): We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.
Keywords: Fibroids; pregnancy; selective progesterone receptor modulators (SPRMs); ulipristal acetate.
Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Source: PubMed