BMI and waist circumference are associated with impaired glucose metabolism and type 2 diabetes in normal weight Chinese adults
Shengxu Li, Jianzhong Xiao, Linong Ji, Jianping Weng, Weiping Jia, Juming Lu, Zhiguang Zhou, Xiaohui Guo, Jie Liu, Zhongyan Shan, Dalong Zhu, Li Chen, Zhigang Zhao, Haoming Tian, Qiuhe Ji, Jiapu Ge, Qiang Li, Lixiang Lin, Zhaojun Yang, Jiang He, Wenying Yang, China National Diabetes and Metabolic Disorders Study Investigators, Guangliang Shan, Wenying Yang, Jianzhong Xiao, Zhaojun Yang, Jiang He, Chung-Shiuan Chen, Shengxu Li, Kunsan Xiang, Jialun Chen, Changyu Pan, Zuzhi Fu, Wenying Yang, Jianzhong Xiao, Zhaojun Yang, Danjie Ruan, Yufeng Li, Shi Bu, Hongliang Li, Peng Wang, Xueli Liu, Zhiyun Xiao, Juming Lu, Jingtao Dou, Nan Jin, Jing Li, Shuyu Wang, Baojing Zhang, Liguang Dong, Jianping Weng, Longyi Zeng, Panwei Mu, Yanhua Zhang, Qiuqiong Yu, Keyi Lin, Yan Sun, Xiaodong Xu, Weiping Jia, Xuhong Hou, Xiaojing Ma, Huijuan Lu, Dajing Zou, Renming Hu, Huilin Gu, Youhua Yao, Weizhen Shen, Junbin Huang, Zhijian Pan, Linong Ji, Xianghai Zhou, Xueyao Han, Xiuying Zhang, Yingying Luo, Xiuqing Sun, Dong Zhao, Huifang Xing, Lei Liu, Xinquan Zhang, Zhongyan Shan, Yaxin Lai, Xiaochun Teng, Ling Shan, Jiani Wang, Liangfeng Shi, Sen Wang, Li Lu, Fengwei Jiang, Beibei Wang, Jie Liu, Ling Hu, Yuying Hou, Haoming Tian, Xingwu Ran, Yan Ren, Hongling Yu, Lisheng Cao, Hualin Lu, Xiaohua Xie, Xilian Gao, Zhong Li, Qiuhe Ji, Fei Chen, Yaping Zhang, Dalong Zhu, Yun Hu, Guoyu Tong, Ning Xu, Jinluo Cheng, Junjian Chen, Fei Wang, Jiong Pei, Jiapu Ge, Wan Yi, Rong Wang, Gang Han, Huijie Mu, Maimaiti Aireti, Lixiang Lin, Gang Chen, Jingxin Zhao, Shuyu Yang, Mingzhu Lin, Yadong Zhang, Fengyuan Zhu, Mei Tu, Shanghua Xu, Weihong Lin, Li Chen, Yu Sun, Xiaolin Dong, Yiling Fu, Kehua Zhou, Jinbo Liu, Zhenzuo Li, Yuxin Xu, Peng Lin, Wenjuan Li, Xiaohui Guo, Junqing Zhang, Aimei Dong, Dongming Huang, Changchun Xue, Junqing Liu, Zhigang Zhao, Guijun Qin, Yong Yan, Peiyu Yao, Qinchu Li, Qiang Li, Kaiting Chen, Nannan Wu, Yan Feng, Xiaoying Liu, Guozhong Li, Zhiguang Zhou, Weili Tang, Qiong Feng, Yuju Qin, Xinwen Qiu, Diaoxiang Xiao, Aiping Qin, Bin Liao, Zifang Gao, Liang Xiang, Shengxu Li, Jianzhong Xiao, Linong Ji, Jianping Weng, Weiping Jia, Juming Lu, Zhiguang Zhou, Xiaohui Guo, Jie Liu, Zhongyan Shan, Dalong Zhu, Li Chen, Zhigang Zhao, Haoming Tian, Qiuhe Ji, Jiapu Ge, Qiang Li, Lixiang Lin, Zhaojun Yang, Jiang He, Wenying Yang, China National Diabetes and Metabolic Disorders Study Investigators, Guangliang Shan, Wenying Yang, Jianzhong Xiao, Zhaojun Yang, Jiang He, Chung-Shiuan Chen, Shengxu Li, Kunsan Xiang, Jialun Chen, Changyu Pan, Zuzhi Fu, Wenying Yang, Jianzhong Xiao, Zhaojun Yang, Danjie Ruan, Yufeng Li, Shi Bu, Hongliang Li, Peng Wang, Xueli Liu, Zhiyun Xiao, Juming Lu, Jingtao Dou, Nan Jin, Jing Li, Shuyu Wang, Baojing Zhang, Liguang Dong, Jianping Weng, Longyi Zeng, Panwei Mu, Yanhua Zhang, Qiuqiong Yu, Keyi Lin, Yan Sun, Xiaodong Xu, Weiping Jia, Xuhong Hou, Xiaojing Ma, Huijuan Lu, Dajing Zou, Renming Hu, Huilin Gu, Youhua Yao, Weizhen Shen, Junbin Huang, Zhijian Pan, Linong Ji, Xianghai Zhou, Xueyao Han, Xiuying Zhang, Yingying Luo, Xiuqing Sun, Dong Zhao, Huifang Xing, Lei Liu, Xinquan Zhang, Zhongyan Shan, Yaxin Lai, Xiaochun Teng, Ling Shan, Jiani Wang, Liangfeng Shi, Sen Wang, Li Lu, Fengwei Jiang, Beibei Wang, Jie Liu, Ling Hu, Yuying Hou, Haoming Tian, Xingwu Ran, Yan Ren, Hongling Yu, Lisheng Cao, Hualin Lu, Xiaohua Xie, Xilian Gao, Zhong Li, Qiuhe Ji, Fei Chen, Yaping Zhang, Dalong Zhu, Yun Hu, Guoyu Tong, Ning Xu, Jinluo Cheng, Junjian Chen, Fei Wang, Jiong Pei, Jiapu Ge, Wan Yi, Rong Wang, Gang Han, Huijie Mu, Maimaiti Aireti, Lixiang Lin, Gang Chen, Jingxin Zhao, Shuyu Yang, Mingzhu Lin, Yadong Zhang, Fengyuan Zhu, Mei Tu, Shanghua Xu, Weihong Lin, Li Chen, Yu Sun, Xiaolin Dong, Yiling Fu, Kehua Zhou, Jinbo Liu, Zhenzuo Li, Yuxin Xu, Peng Lin, Wenjuan Li, Xiaohui Guo, Junqing Zhang, Aimei Dong, Dongming Huang, Changchun Xue, Junqing Liu, Zhigang Zhao, Guijun Qin, Yong Yan, Peiyu Yao, Qinchu Li, Qiang Li, Kaiting Chen, Nannan Wu, Yan Feng, Xiaoying Liu, Guozhong Li, Zhiguang Zhou, Weili Tang, Qiong Feng, Yuju Qin, Xinwen Qiu, Diaoxiang Xiao, Aiping Qin, Bin Liao, Zifang Gao, Liang Xiang
Abstract
Aims: To examine the associations of BMI and waist circumference with glucose metabolism and (pre)diabetes among adults with BMI < 25 kg/m².
Methods: We conducted a cross-sectional study in a nationally representative sample (10,098 men and 17,454 women) of Chinese adults aged ≥ 20 years with BMI < 25 kg/m². Glucose levels after at least 10 hours of overnight fasting, at 30 minutes and at 120 minutes after a standard 75-g oral glucose load were measured. Associations of BMI and waist circumference with outcomes were examined by general linear models for continuous outcomes and by logistic regression models for dichotomous outcomes.
Results: Among those with BMI < 25 kg/m², 18.8% of men and 17.1% of women had abnormal glucose metabolism, including 4.9% of men and 3.8% of women with undiagnosed type 2 diabetes. For each SD increase in BMI (2.1 kg/m²) and waist circumference (8.3 cm), fasting glucose levels increased by 0.128 and 0.170 mmol/L in men, and by 0.112 and 0.167 mmol/L in women, respectively; the corresponding increases for 2-hour post-load glucose levels were 0.121 and 0.217 mmol/L in men, and 0.241 and 0.362 mmol/L in women. When simultaneously included in the same model, these associations with waist circumference were stronger than with BMI.
Conclusion: Obesity measures are associated with abnormal glucose metabolism and diabetes, with central obesity playing a more prominent role than general obesity in Chinese population with BMI < 25 kg/m². Chinese diabetes prevention and treatment programs should incorporate targeting of normal weight adults with central obesity.
Keywords: BMI; China; Glucose metabolism; Type 2 diabetes; Waist circumference.
Conflict of interest statement
Conflict of interest: none declared.
Copyright © 2014 Elsevier Inc. All rights reserved.
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Source: PubMed