The Effects of Recombinant Human Lactoferrin on Immune Activation and the Intestinal Microbiome Among Persons Living with Human Immunodeficiency Virus and Receiving Antiretroviral Therapy
Ornella Sortino, Kathy Huppler Hullsiek, Elizabeth Richards, Adam Rupert, Andrea Schminke, Namo Tetekpor, Mariam Quinones, Rachel Prosser, Tim Schacker, Irini Sereti, Jason V Baker, Ornella Sortino, Kathy Huppler Hullsiek, Elizabeth Richards, Adam Rupert, Andrea Schminke, Namo Tetekpor, Mariam Quinones, Rachel Prosser, Tim Schacker, Irini Sereti, Jason V Baker
Abstract
Lactoferrin modulates mucosal immunity and targets mechanisms contributing to inflammation during human immunodeficiency virus disease. A randomized placebo-controlled crossover clinical trial of recombinant human (rh) lactoferrin was conducted among 54 human immunodeficiency virus-infected participants with viral suppression. Outcomes were tolerability, inflammatory, and immunologic measures, and the intestinal microbiome. The median age was 51 years, and the median CD4+ cell count was 651/µL. Adherence and adverse events did not differ between rh-lactoferrin and placebo. There was no significant effect on plasma interleukin-6 or D-dimer levels, nor on monocyte/T-cell activation, mucosal integrity, or intestinal microbiota diversity. Oral administration of rh-lactoferrin was safe but did not reduce inflammation and immune activation. Clinical Trials Registration: NCT01830595.
Keywords: HIV; immune activation; inflammation; lactoferrin; microbiome.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Source: PubMed