Regenerative potential of leucocyte- and platelet-rich fibrin. Part B: sinus floor elevation, alveolar ridge preservation and implant therapy. A systematic review

Ana B Castro, Nastaran Meschi, Andy Temmerman, Nelson Pinto, Paul Lambrechts, Wim Teughels, Marc Quirynen, Ana B Castro, Nastaran Meschi, Andy Temmerman, Nelson Pinto, Paul Lambrechts, Wim Teughels, Marc Quirynen

Abstract

Aim: To analyse the effect of leucocyte- and platelet-rich fibrin (L-PRF) on bone regeneration procedures and osseointegration.

Materials and methods: An electronic and hand search was conducted in three databases (MEDLINE, EMBASE and Cochrane). Only randomized clinical trials, written in English where L-PRF was applied in bone regeneration and implant procedures, were selected. No follow-up restrictions were applied.

Results: A total of 14 articles were included and processed. Three subgroups were created depending on the application: sinus floor elevation (SFE), alveolar ridge preservation and implant therapy. In SFE, for a lateral window as well as for the trans-alveolar technique, histologically faster bone healing was reported when L-PRF was added to most common xenografts. L-PRF alone improved the preservation of the alveolar width, resulting in less buccal bone resorption compared to natural healing. In implant therapy, better implant stability over time and less marginal bone loss were observed when L-PRF was applied. Meta-analyses could not be performed due to the heterogeneity of the data.

Conclusions: Despite the lack of strong evidence found in this systematic review, L-PRF might have a positive effect on bone regeneration and osseointegration.

Keywords: alveolar ridge preservation; guided bone regeneration; implant therapy; leucocyte- and platelet-rich fibrin; sinus floor elevation.

© 2016 The Authors. Journal of Clinical Periodontology Published by John Wiley & Sons Ltd.

Figures

Figure 1
Figure 1
PRISMA flow diagram.

References

    1. Anitua, E. (1999) Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. International Journal of Oral and Maxillofacial Implants 4, 529–535.
    1. Araujo, M. G. & Lindhe, J. (2005) Dimensional ridge alterations following tooth extraction. An experimental study in the dog. Journal of Clinical Periodontology 32, 212–218.
    1. Baslarli, O. , Tumer, C. , Ugur, O. & Vatankulu, B. (2015) Evaluation of osteoblastic activity in extraction sockets treated with platelet‐rich fibrin. Medicina Oral Patologia Oral Cirugia Bucal 20, e111–e116.
    1. Boora, P. , Rathee, M. & Bhoria, M. (2015) Effect of platelet rich fibrin (PRF) on peri‐implant soft tissue and crestal bone in one‐stage implant placement: a randomized controlled trial. Journal of Clinical and Diagnostic Research, 9, ZC18–ZC21.
    1. Chappuis, V. , Engel, O. , Reyes, M. , Shahim, K. , Nolte, L. P. & Buser, D. (2013) Ridge alterations post‐extraction in the esthetic zone: a 3D analysis with CBCT. Journal of Dental Research 92, 195S–201S.
    1. Choukroun, J. (2001) Une opportunité en paro‐implantologie: le PRF. Implantodontie, 42, 55–62. French.
    1. Diss, A. , Dohan, D. M. , Mouhyi, J. & Mahler, P. (2008) Osteotome sinus floor elevation using Choukroun's platelet‐rich fibrin as grafting material: a 1‐year prospective pilot study with microthreaded implants. Oral surgery, Oral medicine, Oral pathology, Oral radiology, and Endodontics 105, 572–579.
    1. Dohan, D. M. , Andia, I. , Zumstein, M. A. , Zhang, C. Q. , Pinto, N. R. & Bielecki, T. (2014) Classification of platelet concentrates (Platelet‐Rich Plasma‐PRP, Platelet‐Rich Fibrin‐PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons Journal 4, 3–9.
    1. Dohan, D. M. , Choukroun, J. , Diss, A. , Dohan, S. L. , Dohan, A. J. , Mouhyi, J. & Gigly, B. (2006a) Platelet‐rich fibrin (PRF): a second‐generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 101, E37–E44.
    1. Dohan, D. M. , Choukroun, J. , Diss, A. , Dohan, S. L. , Dohan, A. J. , Mouhyi, J. & Gogly, B. (2006b) Platelet‐rich fibrin (PRF): a second‐generation platelet concentrate. Part II: platelet‐related biologic features. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 101, e45–e50.
    1. Farmer, M. & Darby, I. (2014) Ridge dimensional changes following single‐tooth extraction in the aesthetic zone. Clinical Oral Implants Research 25, 272–277.
    1. Gassling, V. , Purcz, N. , Braesen, J. H. , Will, M. , Gierloff, M. , Behrens, E. , Acil, Y. & Wiltfang, J. (2013) Comparison of two different absorbable membranes for the coverage of lateral osteotomy sites in maxillary sinus augmentation: a preliminary study. Journal of Craniomaxillofacial Surgery 41, 76–82.
    1. Gürbüzer, B. , Pikdoken, L. , Tunali, M. , Urhan, M. , Kucukodaci, Z. & Ercan, F. (2010) Scintigraphic evaluation of osteoblastic activity in extraction sockets treated with platelet‐rich fibrin. Journal of Oral and Maxillofacial Surgery 68, 980–989.
    1. Hamzacebi, B. , Oduncuoglu, B. & Alaaddinoglu, E. E. (2015) Treatment of peri‐implant bone defects with platelet‐rich fibrin. International Journal of Periodontics and Restorative Dentistry 35, 415–422.
    1. Hauser, F. , Gaydarov, N. , Badoud, I. , Vazquez, L. , Bernard, J. P. & Ammann, P. (2013) Clinical and histological evaluation of postextraction platelet‐rich fibrin socket filling: a prospective randomized controlled study. Implant Dentistry 22, 295–303.
    1. Jung, R. E. , Thoma, D. S. & Hammerle, C. H. (2008) Assessment of the potential of growth factors for localized alveolar ridge augmentation: a systematic review. Journal of Clinical Periodontology 35, 255–281.
    1. Kanayama, T. , Horii, K. , Senga, Y. & Shibuya, Y. (2016) Crestal approach to sinus floor elevation for atrophic maxilla using platelet‐rich fibrin as the only grafting material: a 1‐year prospective study. Implant Dentistry 25, 32–38.
    1. Khorshidi, H. , Raoofi, S. , Bagheri, R. & Banihashemi, H. (2016) Comparison of the mechanical properties of early leukocyte‐ and platelet‐rich fibrin versus PRGF/endoret membranes. International Journal of Dentistry 2016, 1–7. doi:.
    1. Kumar, N. , Prasad, K. , Ramanujam, L. , K, R. , Dexith, J. & Chauhan, A. (2015) Evaluation of treatment outcome after impacted mandibular third molar surgery with the use of autologous platelet‐rich fibrin: a randomized controlled clinical study. Journal of Oral and Maxillofacial Surgery, 73, 1042–1049.
    1. Lee, J. W. , Kim, S. G. , Kim, J. Y. , Lee, Y. C. , Choi, J. Y. , Dragos, R. , Rotatu, H. & Anyang, G. (2012) Restoration of a peri‐implant defect with platelet‐rich fibrin. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 113, 459–463.
    1. Lin, G. H. , Lim, G. , Chan, H. L. , Giannobile, W. V. & Wang, H. L. (2015) Recombinant human bone morphogenetic protein 2 outcomes for maxillary sinus floor augmentation: a systematic review and meta‐analysis. Clinical Oral Implants Research 00, 1–11.
    1. Marenzi, G. , Riccitiello, F. , Tia, M. , di Lauro, A. & Sammartino, G. (2015) Influence of leucocyte‐ and platelet‐rich fibrin (L‐PRF) in the healing of simple postextraction sockets: a split‐mouth study. BioMed Research International 2015, 1–6, In‐Press. doi:.
    1. Marx, R. E. (2001) Platelet‐rich plasma (PRP): What is PRP and what is not PRP? Implant Dentistry 10, 225–228.
    1. Matras, H. (1970) Effect of various fibrin preparations on reimplantations in the rat skin. Österreichische Zeitschrift für Stomatologie 67, 338–359.
    1. Mazor, Z. , Horowitz, R. A. , Del Corso, M. , Prasad, H. S. , Rohrer, M. D. & Dohan, D. M. (2009) Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet‐rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. Journal of Periodontology 80, 2056–2064.
    1. McAllister, B. S. & Haghighat, K. (2007) Bone augmentation techniques. Journal of Periodontology 78, 377–396.
    1. Moher, D. , Liberati, A. , Tetzlaff, J. & Altman, D. G. (2009) Preferred reporting items for systematic reviews and meta‐analyses: the PRISMA statement. PLoS Medicine 6, 1–6.
    1. Öncü, E. & Alaadinŏglu, E. E. (2015) The effect of platelet‐rich fibrin on implant stability. International Journal of Oral and Maxillofacial Implants 30, 578–582.
    1. Öncü, E. , Bayram, B. , Kantarci, A. , Gülsever, S. & Alaaddinoğlu, E. E. (2016) Positive effect of platelet rich fibrin on osseointegration. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 21, 601–607, doi:.
    1. Pjetursson, B. E. & Lang, N. P. (2014) Sinus floor elevation utilizing the transalveolar approach. Periodontology 2000 66, 59–71.
    1. PRISMA statement . Preferred Reporting Items for Systematic Reviews and Meta‐Analyses. Available at: (accessed 04 augustus 2015).
    1. Rowe, S. L. , Lee, S. Y. & Stegemann, J. P. (2007) Influence of thrombin concentration on the mechanical and morphological properties of cell‐seeded fibrin hydrogels. Acta Biomaterialia 3, 59–67.
    1. Schär, M. O. , Diaz‐Romero, J. , Kohl, S. , Zumstein, M. A. & Nesic, D. (2015) Platelet‐rich concentrates differentially release growth factors and induce cell migration in vitro. Clinical Orthopaedics and Related Research 5, 1635–1643.
    1. Simonpieri, A. , Choukroun, J. , Del Corso, M. , Sammartino, G. & Dohan, D. M. (2011) Simultaneous sinus‐lift and implantation using microthreaded implants and leukocyte‐ and platelet‐rich fibrin as sole grafting material: a six‐year experience. Implant Dentistry 20, 2–12.
    1. Singh, A. , Kohli, M. & Gupta, N. (2012) Platelet rich fibrin: a novel approach for osseous regeneration. Journal of Maxillofacial and Oral Surgery 11, 430–434.
    1. Suttapreyasri, S. & Leepong, N. (2013) Influence of platelet‐rich fibrin on alveolar ridge preservation. Journal of Craniofacial Surgery 24, 1088–1094.
    1. Tajima, N. , Ohba, S. , Sawase, T. & Asahina, I. (2013) Evaluation of sinus floor augmentation with simultaneous implant placement using platelet‐rich fibrin as sole grafting material. International Journal of Oral and Maxillofacial Implants 28, 77–83.
    1. Tatullo, M. , Marrelli, M. , Cassetta, M. , Pacifici, A. , Stefanelli, L. V. , Scacco, S. , Dipalma, G. , Pacifici, L. & Inchingolo, F. (2012) Platelet rich fibrin (P.R.F.) in reconstructive surgery of atrophied maxillary bones: clinical and histological evaluations. International Journal of Medical Sciences 9, 872–880.
    1. Toffler, M. , Toscano, N. & Holtzclaw, D. (2010) Osteotome‐mediated sinus floor elevation using only platelet‐rich fibrin: an early report on 110 patients. Implant Dentistry 19, 447–456.
    1. Vignoletti, F. , Nunez, J. & Sanz, M. (2014) Soft tissue wound healing at teeth, dental implants and the edentulous ridge when using barrier membranes, growth and differentiation factors and soft tissue substitutes. Journal of Clinical Periodontology 41 (Suppl.), S23–S35.
    1. Yelamali, T. & Saikrishna, D. (2015) Role of platelet rich fibrin and platelet rich plasma in wound healing of extracted third molar sockets: a comparative study. Journal of Maxillofacial and Oral Surgery 14, 410–416.
    1. Zhang, Y. , Tangl, S. , Huber, C. D. , Lin, Y. , Qiu, L. & Rausch‐Fan, X. (2012) Effects of Choukroun's platelet‐rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a histological and histomorphometric study. Journal of Craniomaxillofacial Surgery 40, 321–328.

Source: PubMed

Sponsor e collaboratori

Condizioni mediche

Interventi farmacologici

3
Sottoscrivi