Innovative method of alopecia treatment by autologous adipose-derived SVF

Sun Jong Kim, Myung Jin Kim, Young Jun Lee, Joo Chan Lee, Ji Hyang Kim, Do Ha Kim, Young Hoo Do, Jun Woo Choi, Sung Ill Chung, Byung-Rok Do, Sun Jong Kim, Myung Jin Kim, Young Jun Lee, Joo Chan Lee, Ji Hyang Kim, Do Ha Kim, Young Hoo Do, Jun Woo Choi, Sung Ill Chung, Byung-Rok Do

Abstract

Background: Alopecia refers to a condition developed by gradual reduction of hair loss by various abnormal causes such as endocrine system, genetic factors, and stress. Stromal vascular fraction (SVF) isolated from the fat is one of the latest innovative solutions in the field of regeneration therapy. We focused on presenting effectiveness of clinical cases to improve AGA through transplantation of autologous SVF into the scalp.

Objective: To confirm the efficacy of the autologous SVF usage to the patients with AGA.

Methods: Nine patients (age range 43-64 years; 4 men, grade IV to V and 5 women, grade I to III), who are suffering from androgenic alopecia (AGA), were treated with single transplantation of autologous SVF in the upper scalp. Autologous SVF was isolated and characterized prior to the injection of live 7-9 × 106 cells into the patients' treatment site. The hair loss improvement effect was assessed by three test criteria: hair skin quality, hair thickness and hair density 3 and 6 months after post-injection compared to pre-injection status.

Results: Hair density of SVF-treated side was significantly increased after 3 and 6 months of transplantation compared to non-treated side (P = 0.01 and P = 0.009 per each). And significant improvement in the score of the keratin on the scalp was seen in the injected area as compared to the non-injected area 6 months after transplantation (P = 0.032). Although thickness increase was observed at 3 and 6 months after transplantation, there was no statistical significance (P = 0.142 and 0.155, respectively).

Conclusions: One transplantation of autologous SVF for the AGA patients, hair density and score for the keratin were significantly increased within 6 months. This study shows that SVF is a very effective way to treat hair loss and most of subjects are satisfied with the result after treatment.

Keywords: Alopecia; Baldness; Hair loss; Stromal vascular fraction (SVF).

Conflict of interest statement

All authors who participated in this study agree they do not have any interests to conflict each other. The authors belonging to HurimBioCell supported only operation of Huricell device, while the data from the clinical trials were fully calculated and analyzed by Top Plastic Surgery. Accordingly, there is no mutual interest between two parties regarding the issue on this paper.

© 2021. The Author(s).

Figures

Fig. 1
Fig. 1
Analysis of hair density change before and after the treatment of SVF. The difference of median value between treated and non-treated side is significantly difference at 3 and 6 months (*Wilcoxon signed-rank test, P < 0.05, n = 9)
Fig. 2
Fig. 2
Changes of hair thickness before and after the treatment of SVF. The difference of median value between treated and non-treated side was increased at 3 and 6 months. However, there was no statistical significance (Wilcoxon signed-rank test, n = 9)
Fig. 3
Fig. 3
Representative image of keratin on scalp pre-injection and 6 months after SVF treatment. The median value between treatment and non-treatment side was significantly different at 6 month (Wilcoxon signed-rank test, *P < 0.05). 51-year-old men (A, B) and 43-year-old woman (C, D) decreased the score of keratin on scalp after 6 months post-injection
Fig. 4
Fig. 4
Representative photographs of the AGA improvement after SVF treatment. Baseline (pre-injection) versus 6 months (post-injection) global photographs after treatment

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