Role of Epidural Analgesia within an ERAS Program after Laparoscopic Colorectal Surgery: A Review and Meta-Analysis of Randomised Controlled Studies

Giuseppe Borzellino, Nader Kamal Francis, Olivier Chapuis, Evguenia Krastinova, Valérie Dyevre, Michele Genna, Giuseppe Borzellino, Nader Kamal Francis, Olivier Chapuis, Evguenia Krastinova, Valérie Dyevre, Michele Genna

Abstract

Introduction. Epidural analgesia has been a cornerstone of any ERAS program for open colorectal surgery. With the improvements in anesthetic and analgesic techniques as well as the introduction of the laparoscopy for colorectal resection, the role of epidural analgesia has been questioned. The aim of the review was to assess through a meta-analysis the impact of epidural analgesia compared to other analgesic techniques for colorectal laparoscopic surgery within an ERAS program. Methods. Literature research was performed on PubMed, Embase, and the Cochrane Library. All randomised clinical trials that reported data on hospital stay, postoperative complications, and readmissions rates within an ERAS program with and without an epidural analgesia after a colorectal laparoscopic resection were included. Results. Five randomised clinical trials were selected and a total of 168 patients submitted to epidural analgesia were compared to 163 patients treated by an alternative analgesic technique. Pooled data show a longer hospital stay in the epidural group with a mean difference of 1.07 (95% CI 0.06-2.08) without any significant differences in postoperative complications and readmissions rates. Conclusion. Epidural analgesia does not seem to offer any additional clinical benefits to patients undergoing laparoscopic colorectal surgery within an ERAS program.

Figures

Figure 1
Figure 1
PRISMA diagram of study selection.
Figure 2
Figure 2
Risk of bias assessment.
Figure 3
Figure 3
Hospital stay.
Figure 4
Figure 4
Postoperative complications.
Figure 5
Figure 5
Readmissions.

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Source: PubMed

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