Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity
Henry P Parkman, Katherine Yates, William L Hasler, Linda Nguyen, Pankaj J Pasricha, William J Snape, Gianrico Farrugia, Kenneth L Koch, Thomas L Abell, Richard W McCallum, Linda Lee, Aynur Unalp-Arida, James Tonascia, Frank Hamilton, National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium, Pankaj Jay Pasricha, Linda Nguyen, Nighat Ullah, William Snape, Robin Bishop, Nata DeVole, Mary Greene, Sue Louiseau, Amy Marincek, Shelly Parker, Eve Pillor, Courtney Ponsetto, Katerina Shetler, Gianrico Farrugia, Cheryl Bernard, Matt Lurken, Henry P Parkman, Siva Doma, Javier Gomez, Steven Kantor, Vanessa Lytes, Amiya Palit, Zeeshan Ramzan, Priyanka Sachdeva, Kellie Simmons, Richard W McCallum, Reza Hejazi, Irene Sarosiek, Denise Vasquez, Natalia Vega, William Hasler, Michelle Atkinson, Radoslav Coleski, Thomas Abell, JoAnne Fordham, Olivia Henry, Archana Kedar, Valerie McNair, Susanne Pruett, Margaret Smith, Danielle Spree, Kenneth Koch, Lynn Baxter, Jorge Calles, Samantha Culler, Judy Hooker, Paula Stuart, Frank Hamilton, Steven James, Rebecca Torrance, Rebekah Van Raaphorst, James Tonascia, Patricia Belt, Ryan Colvin, Michele Donithan, Mika Green, Milana Isaacson, Wana Kim, Linda Lee, Alison Lydecker, Pamela Mann, Laura Miriel, Alice Sternberg, Aynur Unalp-Arida, Mark Van Natta, Ivana Vaughn, Laura Wilson, Katherine Yates, Henry P Parkman, Katherine Yates, William L Hasler, Linda Nguyen, Pankaj J Pasricha, William J Snape, Gianrico Farrugia, Kenneth L Koch, Thomas L Abell, Richard W McCallum, Linda Lee, Aynur Unalp-Arida, James Tonascia, Frank Hamilton, National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium, Pankaj Jay Pasricha, Linda Nguyen, Nighat Ullah, William Snape, Robin Bishop, Nata DeVole, Mary Greene, Sue Louiseau, Amy Marincek, Shelly Parker, Eve Pillor, Courtney Ponsetto, Katerina Shetler, Gianrico Farrugia, Cheryl Bernard, Matt Lurken, Henry P Parkman, Siva Doma, Javier Gomez, Steven Kantor, Vanessa Lytes, Amiya Palit, Zeeshan Ramzan, Priyanka Sachdeva, Kellie Simmons, Richard W McCallum, Reza Hejazi, Irene Sarosiek, Denise Vasquez, Natalia Vega, William Hasler, Michelle Atkinson, Radoslav Coleski, Thomas Abell, JoAnne Fordham, Olivia Henry, Archana Kedar, Valerie McNair, Susanne Pruett, Margaret Smith, Danielle Spree, Kenneth Koch, Lynn Baxter, Jorge Calles, Samantha Culler, Judy Hooker, Paula Stuart, Frank Hamilton, Steven James, Rebecca Torrance, Rebekah Van Raaphorst, James Tonascia, Patricia Belt, Ryan Colvin, Michele Donithan, Mika Green, Milana Isaacson, Wana Kim, Linda Lee, Alison Lydecker, Pamela Mann, Laura Miriel, Alice Sternberg, Aynur Unalp-Arida, Mark Van Natta, Ivana Vaughn, Laura Wilson, Katherine Yates
Abstract
Background & aims: Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity. We studied characteristics of patients with IG enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium Registry.
Methods: Data from medical histories, symptom questionnaires, and 4-hour gastric emptying scintigraphy studies were obtained from patients with IG.
Results: The mean age of 243 patients with IG studied was 41 years; 88% were female, 46% were overweight, 50% had acute onset of symptoms, and 19% reported an initial infectious prodrome. Severe delay in gastric emptying (>35% retention at 4 hours) was present in 28% of patients. Predominant presenting symptoms were nausea (34%), vomiting (19%), an abdominal pain (23%). Women had more severe nausea, satiety, constipation, and overall gastroparesis symptoms. Patients who experienced acute-onset IG had worse nausea than those with insidious onset. Overweight patients had more bloating and gastric retention at 2 hours but less severe loss of appetite. Patients with severely delayed gastric emptying had worse vomiting and more severe loss of appetite and overall gastroparesis symptoms. Severe anxiety and depression were present in 36% and 18%, respectively. A total of 86% met criteria for functional dyspepsia, primarily postprandial distress syndrome.
Conclusions: IG is a disorder that primarily affects young women, beginning acutely in 50% of cases; unexpectedly, many patients are overweight. Severe delay in gastric emptying was associated with more severe symptoms of vomiting and loss of appetite. IG is a diverse syndrome that varies by sex, body mass, symptom onset, and delay in gastric emptying.
Trial registration: ClinicalTrials.gov NCT00398801.
Conflict of interest statement
No conflicts of interest exist.
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
Source: PubMed