Association of Adverse Pregnancy Outcomes With Hypertension 2 to 7 Years Postpartum

David M Haas, Corette B Parker, Derek J Marsh, William A Grobman, Deborah B Ehrenthal, Philip Greenland, C Noel Bairey Merz, Victoria L Pemberton, Robert M Silver, Shannon Barnes, Rebecca B McNeil, Kirsten Cleary, Uma M Reddy, Judith H Chung, Samuel Parry, Lauren H Theilen, Elizabeth A Blumenthal, Lisa D Levine, Brian M Mercer, Hyagriv Simhan, LuAnn Polito, Ronald J Wapner, Janet Catov, Ida Chen, George R Saade, NHLBI nuMoM2b Heart Health Study, David M Haas, Corette B Parker, Derek J Marsh, William A Grobman, Deborah B Ehrenthal, Philip Greenland, C Noel Bairey Merz, Victoria L Pemberton, Robert M Silver, Shannon Barnes, Rebecca B McNeil, Kirsten Cleary, Uma M Reddy, Judith H Chung, Samuel Parry, Lauren H Theilen, Elizabeth A Blumenthal, Lisa D Levine, Brian M Mercer, Hyagriv Simhan, LuAnn Polito, Ronald J Wapner, Janet Catov, Ida Chen, George R Saade, NHLBI nuMoM2b Heart Health Study

Abstract

Background Identifying pregnancy-associated risk factors before the development of major cardiovascular disease events could provide opportunities for prevention. The objective of this study was to determine the association between outcomes in first pregnancies and subsequent cardiovascular health. Methods and Results The Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be Heart Health Study is a prospective observational cohort that followed 4484 women 2 to 7 years (mean 3.2 years) after their first pregnancy. Adverse pregnancy outcomes (defined as hypertensive disorders of pregnancy, small-for-gestational-age birth, preterm birth, and stillbirth) were identified prospectively in 1017 of the women (22.7%) during this pregnancy. The primary outcome was incident hypertension (HTN). Women without adverse pregnancy outcomes served as controls. Risk ratios (RR) and 95% CIs were adjusted for age, smoking, body mass index, insurance type, and race/ethnicity at enrollment during pregnancy. The overall incidence of HTN was 5.4% (95% CI 4.7% to 6.1%). Women with adverse pregnancy outcomes had higher adjusted risk of HTN at follow-up compared with controls (RR 2.4, 95% CI 1.8-3.1). The association held for individual adverse pregnancy outcomes: any hypertensive disorders of pregnancy (RR 2.7, 95% CI 2.0-3.6), preeclampsia (RR 2.8, 95% CI 2.0-4.0), and preterm birth (RR 2.7, 95% CI 1.9-3.8). Women who had an indicated preterm birth and hypertensive disorders of pregnancy had the highest risk of HTN (RR 4.3, 95% CI 2.7-6.7). Conclusions Several pregnancy complications in the first pregnancy are associated with development of HTN 2 to 7 years later. Preventive care for women should include a detailed pregnancy history to aid in counseling about HTN risk. Clinical Trial Registration URL: http://www.clinicaltrials.gov Unique identifier: NCT02231398.

Keywords: adverse pregnancy outcomes; hypertension; preeclampsia; preterm birth; risk.

Figures

Figure 1
Figure 1
Flow diagram for participation in analysis. APO indicates adverse pregnancy outcome; HDP, hypertensive disorders of pregnancy; HHS, Heart Health Study; HTN, hypertension; iPTB, indicated preterm birth; nuMoM2b, Nulliparous Pregnancy Outcome Study—Monitoring Mothers‐to‐Be; PE, preeclampsia; PTB, preterm birth; sPTB, spontaneous preterm birth; SB, stillbirth; SGA, small for gestational age.

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