Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014
M Monaco, T Giani, M Raffone, F Arena, A Garcia-Fernandez, S Pollini, Network EuSCAPE-Italy, H Grundmann, A Pantosti, G M Rossolini, A Barbaro, L Campion, M R Catania, A De Bernochi, A M Di Taranto, P A Dusi, S Grandesso, F Luzzaro, E Manso, M Meledandri, A Mencacci, F Milano, G Parisi, P Pecile, A Restelli, A Rocchetti, C Arrigo, M R Rossi, I Santino, M Sarti, A Sartor, M Monaco, T Giani, M Raffone, F Arena, A Garcia-Fernandez, S Pollini, Network EuSCAPE-Italy, H Grundmann, A Pantosti, G M Rossolini, A Barbaro, L Campion, M R Catania, A De Bernochi, A M Di Taranto, P A Dusi, S Grandesso, F Luzzaro, E Manso, M Meledandri, A Mencacci, F Milano, G Parisi, P Pecile, A Restelli, A Rocchetti, C Arrigo, M R Rossi, I Santino, M Sarti, A Sartor
Abstract
Consecutive non-replicate clinical isolates (n=191) of carbapenem non-susceptible Enterobacteriaceae were collected from 21 hospital laboratories across Italy from November 2013 to April 2014 as part of the European Survey on Carbapenemase-producing Enterobacteriaceae (EuSCAPE) project. Klebsiella pneumonia carbapenemase-producing K. pneumoniae (KPC-KP) represented 178 (93%) isolates with 76 (43%) respectively resistant to colistin, a key drug for treating carbapenamase-producing Enterobacteriaceae. KPC-KP colistin-resistant isolates were detected in all participating laboratories. This underscores a concerning evolution of colistin resistance in a setting of high KPC-KP endemicity.
Source: PubMed