Quality of life in thyroid cancer patients: a literature review

Elena Bãrbuş, Claudiu Peştean, Maria Iulia Larg, Doina Piciu, Elena Bãrbuş, Claudiu Peştean, Maria Iulia Larg, Doina Piciu

Abstract

Introduction: Quality of life (QoL) has received increasing interest in the last years, especially in patients with cancer. This article aims to analyze a selection of medical research papers regarding the quality of life in patients with thyroid carcinoma. We overviewed the main QoL aspects derived from several studies and highlighted those less researched issues, which could represent a solid base for future clinical studies.

Method: We used an integrative selection method of medical literature, choosing mostly "free access" studies, as it was considered that they could be easily viewed, searched and researched including by patients.

Results: After an integrative literature review, we selected 16 relevant studies. Patients with thyroid cancer have several factors influencing their QoL, with both physical and psychological impact. The decisive factors are the quality of the surgical act, radioiodine therapy, follow-up using rh-TSH vs. hormonal withdrawal, access to behavioral help and the relationship with their physician.

Conclusion: We must understand the emotional impact of the cancer diagnosis on the patient and we must collaborate in order to help the patient restore the psychosomatic balance and to recover the quality of life.

Keywords: iodine radioisotopes; quality of life; thyroid neoplasms.

References

    1. Piciu D, Irimie A. Diagnosis and treatment guidelines in thyroid carcinoma. American and European consensus, adapted to Romania. Acta Endocrinologica. 2007;3(1):103–115.
    1. Mizokami T, Wu Li A, El-Kaissi S, Wall JR. Stress and thyroid autoimmunity. Thyroid. 2004;14(12):1047–1055.
    1. Piciu D. Nuclear Endocrinology. Berlin: Springer Verlag; 2012.
    1. Greer S, Watson M. Mental adjustment to cancer: its measurement and prognostic importance. Cancer Surv. 1987;6(3):439–453.
    1. dos Vigário PS, Chachamovitz DS, de Teixeira PF, de Rocque ML, Santos ML, Vaisman M. Exercise is associated with better quality of life in patients on TSH-suppressive therapy with levothyroxine for differentiated thyroid carcinoma. Arq Bras Endocrinol Metabol. 2014;58(3):274–281.
    1. Gamper EM, Wintner LM, Rodrigues M, Buxbaum S, Nilica B, Singer S, et al. Persistent quality of life impairments in differentiated thyroid cancer patients: results from a monitoring programme. Eur J Nucl Med Mol Imaging. 2015;42(8):1179–1188.
    1. Duan H, Gamper E, Becherer A, Hoffmann M. Quality of life aspects in the management of thyroid cancer. Oral Oncol. 2015;51(6):S1–S5.
    1. Choi Y, Lee JH, Kim YH, Lee YS, Chang HS, Park CS, et al. Impact of postthyroidectomy scar on the quality of life of thyroid cancer patients. Ann Dermatol. 2014;26(6):693–699.
    1. Dimov RS. The effect of neck dissection on quality of life in patients with differentiated thyroid cancer. Gland Surg. 2013;2(4):219–226.
    1. Rubic M, Kuna SK, Tesic V, Samardzic T, Despot M, Huic D. The most common factors influencing on quality of life of thyroid cancer patients after thyroid hormone withdrawal. Psychiatr Danub. 2014;26( Suppl 3):520–527.
    1. Nygaard B, Bastholt L, Bennedbæk FN, Klausen TW, Bentzen J. A placebo-controlled, blinded and randomised study on the effects of recombinant human thyrotropin on quality of life in the treatment of thyroid cancer. Eur Thyroid J. 2013;2:195–202.
    1. Sawka AM, Goldstein DP, Brierley JD, Tsang RW, Rotstein L, Ezzat S, et al. The impact of thyroid cancer and post-surgical radioactive iodine treatment on the lives of thyroid cancer survivors: a qualitative study. PLoS One. 2009;4(1) doi: 10.1371/journal.pone.0004191.
    1. Taïeb D, Baumstarck-Barrau K, Sebag F, Fortanier C, De Micco C, Loundou A, et al. Heath-related quality of life in thyroid cancer patients following radioiodine ablation. Health Qual Life Outcomes. 2011 May 13;9:33.
    1. Wu HX, Zhong H, Xu YD, Xu CP, Zhang Y, Zhang W. Psychological and behavioral intervention improves the quality of life and mental health of patients suffering from differentiated thyroid cancer treated with postoperative radioactive iodine-131. Neuropsychiatr Dis Treat. 2016 May 2;12:1055–60.
    1. Watt T, Hegedüs L, Groenvold M, Bjorner JB, Rasmussen AK, Bonnema SJ, et al. Validity and reliability of the novel thyroid-specific quality of life questionnaire, ThyPRO. Eur J Endocrinol. 2010;162(1):161–167.
    1. Jeong Y, Choi J, Ahn AL, Oh EJ, Oh HK, Cho DY, et al. Validation of the Korean version of the thyroid cancer-specific quality of life questionnaire. Ann Surg Treat Res. 2015;89(6):287–294.
    1. Lee JI, Kim SH, Tan AH, Kim HK, Jang HW, Hur KY, et al. Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea. Health Qual Life Outcomes. 2010 Sep 15;8:101.
    1. Metallo M, Groza L, Brunaud L, Klein M, Weryha G, Feigerlova E. Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I(131) during Adolescence and Young Adulthood. Int J Endocrinol. 2016;2016:7586482. doi: 10.1155/2016/7586482.
    1. Giusti M, Melle G, Fenocchio M, Mortara L, Cecoli F, Caorsi V, et al. Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma. J Zhejiang Univ Sci B. 2011;12(3):163–173.
    1. Vega-Vasquez MA, Gonzalez-Rodriguez L, Santiago-Rodriguez EJ, Garces-Dominguez A, Shum LM, Tirado-Gomez M, et al. Quality of life-in patients with differentiated thyroid cancer at the general endocrinology clinics of the University Hospital of Puerto Rico. Bol Asoc Med P R. 2015;107(1):25–31.
    1. National Comprehensive Cancer Network (NCCN) Thyroid Carcinoma version 1.2016. National Comprehensive Cancer Network; 2015. NCCN Clinical Practice Guidelines in Oncology.
    1. Perros P, Boelaert K, Colley S, Evans C, Evans RM, Gerrard Ba G, et al. Guidelines for the management of thyroid cancer. Clin Endocrinol (Oxf) 2014;81( suppl 1):1–122.
    1. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016;26(1):1–133.

Source: PubMed

3
Sottoscrivi