Relation of maternal vitamin D status with gestational diabetes mellitus and perinatal outcome

Niyazoglu Mutlu, Hatipoglu Esra, Aydogan Begum, Dellal Fatma, Yavuz Arzu, Hacioglu Yalcin, Kaya Fatih, Kumru Selahattin, Niyazoglu Mutlu, Hatipoglu Esra, Aydogan Begum, Dellal Fatma, Yavuz Arzu, Hacioglu Yalcin, Kaya Fatih, Kumru Selahattin

Abstract

Objective: To investigate the relationship between maternal vitamin D status and glucose intolerance, and its impact on pregnant women and their newborns.

Methods: A cohort of pregnant women were divided into three groups: women with gestational diabetes mellitus, ones with normal results both after the 50 gr and 100 gr OGTT (CG-1) and ones having a positive result after the 50 gr OGTT screening but negative results for gestational diabetes mellitus (GDM) after the 100 gr OGTT (CG-2).

Results: The newborn length in CG-1 was greater than in GDM and CG-2 (p= 0.002 and p= 0.02). Fasting blood glucose and insulin resistance (IR) were negatively correlated with length of the newborns (r=-0.3, p=0.03 and r=-0.3, p=0.01). The newborns of women with GDM had lower APGAR-1 and 5 scores than those of CG-1 and CG-2 (APGAR-1 p= 0.001 and p= 0.004, APGAR-5 p=0.005 and p=0.007, respectively). APGAR scores were correlated negatively with IR (APGAR-1 r=-0.32, p=0.01, APGAR-5 r=-0.3, p=0.03) and positively with 25OHD levels (APGAR-1 r=0.3, p=0.01, APGAR-5 r=0.3, p=0.02).

Conclusion: Vitamin D deficiency, gestational diabetes and insulin resistance are interrelated. Severe vitamin D deficiency during pregnancy is associated with poor pregnancy and neonatal outcome.

Keywords: Vitamin D deficiency; gestational diabetes; insulin resistance; pregnancy and neonatal outcome.

Figures

https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4480463/bin/AFHS1502-0523Fig1.jpg
https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4480463/bin/AFHS1502-0523Fig2.jpg
https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4480463/bin/AFHS1502-0523Fig3.jpg

Source: PubMed

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