Alfacalcidol as a modulator of growth of low grade non-Hodgkin's lymphomas

D Cunningham, N L Gilchrist, R A Cowan, G J Forrest, C S McArdle, M Soukop, D Cunningham, N L Gilchrist, R A Cowan, G J Forrest, C S McArdle, M Soukop

Abstract

Ten patients with low grade non-Hodgkin's lymphoma (seven follicular small cleaved and three small lymphocytic) were treated with 1 microgram oral alfacalcidol (1 alpha-hydroxycholecalciferol) daily. Of the seven patients with lymphomas of follicular small cleaved subtype, one achieved complete and three partial remission, whereas none of three patients with small lymphocytic lymphomas responded. In seven of the 10 patients, 1,25(OH)2D3 receptors were measured in tissue from lymph nodes, and a positive correlation between the presence and amount of receptor and response to alfacalcidol was found. These preliminary data suggest that alfacalcidol has appreciable antitumour activity in low grade non-Hodgkin's lymphomas.

References

    1. Cancer. 1975 Feb;35(2):354-7
    1. J Biol Chem. 1951 Nov;193(1):265-75
    1. Natl Cancer Inst Monogr. 1976 Nov;44:35-8
    1. Cancer Treat Rep. 1977 Sep;61(6):1057-66
    1. Cancer. 1978 Aug;42(2):808-11
    1. Clin Haematol. 1979 Oct;8(3):667-84
    1. Cancer. 1981 Jan 1;47(1):207-14
    1. Cancer Treat Rep. 1981 May-Jun;65(5-6):413-8
    1. Proc Natl Acad Sci U S A. 1981 Aug;78(8):4990-4
    1. Proc Natl Acad Sci U S A. 1983 Jan;80(1):210-4
    1. Tohoku J Exp Med. 1982 Dec;138(4):445-6
    1. Cancer Res. 1983 Apr;43(4):1891-8
    1. Leuk Res. 1983;7(1):51-5
    1. Science. 1983 Sep 16;221(4616):1181-3
    1. J Clin Endocrinol Metab. 1984 Jan;58(1):91-8
    1. Nature. 1983 Dec 1-7;306(5942):492-4
    1. Science. 1984 Jun 29;224(4656):1438-40
    1. J Clin Invest. 1984 Aug;74(2):657-61
    1. N Engl J Med. 1984 Dec 6;311(23):1471-5
    1. Steroids. 1975 Oct;26(4):538-42

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