Effect of HIV self-testing on the number of sexual partners among female sex workers in Zambia

Catherine E Oldenburg, Michael M Chanda, Katrina F Ortblad, Magdalene Mwale, Steven Chongo, Nyambe Kamungoma, Catherine Kanchele, Andrew Fullem, Caitlin Moe, Leah G Barresi, Guy D Harling, Till Bärnighausen, Catherine E Oldenburg, Michael M Chanda, Katrina F Ortblad, Magdalene Mwale, Steven Chongo, Nyambe Kamungoma, Catherine Kanchele, Andrew Fullem, Caitlin Moe, Leah G Barresi, Guy D Harling, Till Bärnighausen

Abstract

Objectives: To assess the effect of two health system approaches to distribute HIV self-tests on the number of female sex workers' client and nonclient sexual partners.

Design: Cluster randomized controlled trial.

Methods: Peer educators recruited 965 participants. Peer educator-participant groups were randomized 1 : 1 : 1 to one of three arms: delivery of HIV self-tests directly from a peer educator, free facility-based delivery of HIV self-tests in exchange for coupons, or referral to standard-of-care HIV testing. Participants in all three arms completed four peer educator intervention sessions, which included counseling and condom distribution. Participants were asked the average number of client partners they had per night at baseline, 1 and 4 months, and the number of nonclient partners they had in the past 12 months (at baseline) and in the past month (at 1 month and 4 months).

Results: At 4 months, participants reported significantly fewer clients per night in the direct delivery arm (mean difference -0.78 clients, 95% CI -1.28 to -0.28, P = 0.002) and the coupon arm (-0.71, 95% CI -1.21 to -0.21, P = 0.005) compared with standard of care. Similarly, they reported fewer nonclient partners in the direct delivery arm (-3.19, 95% CI -5.18 to -1.21, P = 0.002) and in the coupon arm (-1.84, 95% CI -3.81 to 0.14, P = 0.07) arm compared with standard of care.

Conclusion: Expansion of HIV self-testing may have positive behavioral effects enhancing other HIV prevention efforts among female sex workers in Zambia.

Trial registration: ClinicalTrials.gov NCT02827240.

Figures

Fig. 1
Fig. 1
CONSORT flow diagram of screened, randomized, and analyzed participants.
Fig. 2
Fig. 2
Mean difference in number of client (a) and nonclient (b) partners at each time point in the direct delivery (circle) and coupon (square) arms, overall (red) and by self-reported HIV status (negative = green; positive = blue).

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Source: PubMed

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