Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen
Anthony J Lee, Ronald J Bosch, Scott R Evans, Kunling Wu, Taylor Harrison, Philip Grant, David B Clifford, Anthony J Lee, Ronald J Bosch, Scott R Evans, Kunling Wu, Taylor Harrison, Philip Grant, David B Clifford
Abstract
The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95% CI) of PN and SPN were 31% (23, 40%) and 5% (2, 11%) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.
Trial registration: ClinicalTrials.gov NCT00001137.
Conflict of interest statement
Conflict of Interest
The authors declare that they have no conflict of interest.
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Source: PubMed