Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion

Rebecca J Brown, Mary Walter, Kristina I Rother, Rebecca J Brown, Mary Walter, Kristina I Rother

Abstract

Objective: The goal of this study was to determine the effect of artificial sweeteners on glucose, insulin, and glucagon-like peptide (GLP)-1 in humans.

Research design and methods: For this study, 22 healthy volunteers (mean age 18.5 +/- 4.2 years) underwent two 75-g oral glucose tolerance tests with frequent measurements of glucose, insulin, and GLP-1 for 180 min. Subjects drank 240 ml of diet soda or carbonated water, in randomized order, 10 min prior to the glucose load.

Results: Glucose excursions were similar after ingestion of carbonated water and diet soda. Serum insulin levels tended to be higher after diet soda, without statistical significance. GLP-1 peak and area under the curve (AUC) were significantly higher with diet soda (AUC 24.0 +/- 15.2 pmol/l per 180 min) versus carbonated water (AUC 16.2 +/- 9.0 pmol/l per 180 min; P = 0.003).

Conclusions: Artificial sweeteners synergize with glucose to enhance GLP-1 release in humans. This increase in GLP-1 secretion may be mediated via stimulation of sweet-taste receptors on L-cells by artificial sweetener.

Figures

Figure 1
Figure 1
Glucose (A), insulin (B), and GLP-1 (C) levels during 75-g OGTTs in 22 healthy subjects. Carbonated water (○) or diet soda sweetened with sucralose and acesulfame-K (■) was given orally at time −10 min, and glucose was given at time 0 min. Data are means ± SEM.

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Source: PubMed

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