Mindfulness Is Associated With Treatment Response From Nonpharmacologic Exercise Interventions in Knee Osteoarthritis

Abstract

Objective: To examine the association between baseline mindfulness and response from exercise interventions in knee osteoarthritis (OA).

Design: Cohort study; responder analysis of a clinical trial subset.

Setting: Urban tertiary care academic hospital.

Participants: Participants with symptomatic, radiographic knee OA (N=86; mean age, 60y; 74% female; 48% white).

Interventions: Twelve weeks (twice per week) of Tai Chi or physical therapy exercise.

Main outcome measures: Treatment response was defined using Osteoarthritis Research Society International criteria indicating meaningful improvements in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, WOMAC function, or Patient Global Assessment scores. At baseline, participants completed the Five Facet Mindfulness Questionnaire (mean total score, 142±17) and were grouped into 3 categories of total mindfulness: higher, medium, or lower. Relative risk (RR) ratios were used to compare treatment response across groups.

Results: Participants with higher total mindfulness were 38% (95% confidence interval [CI], 1.05-1.83) more likely to meet responder criteria than those with lower mindfulness. We found no significant difference between medium and lower mindfulness groups (RR=1.0; 95% CI, 0.69-1.44). Among the 5 mindfulness facets, medium acting-with-awareness was 46% (95% CI, 1.09-1.96) more likely to respond than lower acting-with-awareness, and higher acting-with-awareness was 34% more likely to respond, but this did not reach significance (95% CI, 0.97-1.86).

Conclusions: In this study, higher mindfulness, primarily driven by its acting-with-awareness facet, was significantly associated with a greater likelihood of response to nonpharmacologic exercise interventions in knee OA. This suggests that mindfulness-cultivating interventions may increase the likelihood of response from exercise.

Trial registration: ClinicalTrials.gov NCT01258985.

Keywords: Exercise; Mindfulness; Osteoarthritis; Physical Therapy Modalities; Rehabilitation; Tai Ji.

Conflict of interest statement

Conflicts of Interest: JBW has research funding from PCORI (Patient-Centered Outcome Research Institute) for “A Method for Patient-Centered Enrollment in Comparative Effectiveness Trials: Mathematical Equipoise” which is examining total knee replacement for osteoarthritis. The remaining authors report no conflicts of interest. We certify that the full article is an original work and is not being considered for publication elsewhere.

Copyright © 2017 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Figures

Figure 1

Inclusion/Exclusion Criteria

Figure 2. Sub-study Flow Diagram

FFMQ = Five Facet Mindfulness Questionnaire.