Evaluation of the microscopic observation drug susceptibility assay for the detection of first- and second-line drug susceptibility for Mycobacterium tuberculosis
Donald G Catanzaro, Andre P Trollip, Marva Seifert, Sophia B Georghiou, Richard S Garfein, Timothy C Rodwell, Antonino Catanzaro, Kathleen D Eisenach, Donald G Catanzaro, Andre P Trollip, Marva Seifert, Sophia B Georghiou, Richard S Garfein, Timothy C Rodwell, Antonino Catanzaro, Kathleen D Eisenach
Abstract
A new multi-national study of the non-commercial MODS assay shows excellent performance in detecting M/XDR-tuberculosis
Trial registration: ClinicalTrials.gov NCT02170441.
Figures
Receiver operating characteristic curves for capreomycin. In the current study and that of TROLLIP et al. [6], the reference drug susceptibility testing (DST) method was MGIT960 with a critical concentration of 2.5 μg⋅mL−l (n=729 and n = 55, respectively); in the study of FITZWATER et al. [13], the reference DST method was a proportional method with an unreported critical concentration (n=94).
Source: PubMed