Clostridium difficile vaccine and serum immunoglobulin G antibody response to toxin A
Samer Aboudola, Karen L Kotloff, Lorraine Kyne, Michel Warny, Eoin C Kelly, Stavros Sougioultzis, Paul J Giannasca, Thomas P Monath, Ciarán P Kelly, Samer Aboudola, Karen L Kotloff, Lorraine Kyne, Michel Warny, Eoin C Kelly, Stavros Sougioultzis, Paul J Giannasca, Thomas P Monath, Ciarán P Kelly
Abstract
There is a strong association between serum antibody responses to toxin A and protection against Clostridium difficile diarrhea. A parenteral C. difficile toxoid vaccine induced very-high-level responses to anti-toxin A immunoglobulin G (IgG) in the sera of healthy volunteers. After vaccination, the concentrations of anti-toxin A IgG in the sera of all 30 recipients exceeded the concentrations that were associated with protection in previous clinical studies. Furthermore, the median concentration of serum anti-toxin A IgG in the test group was 50-fold higher than the previous threshold. These findings support the feasibility of using a vaccine to protect high-risk individuals against C. difficile-associated diarrhea and colitis.
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Source: PubMed